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Outcomes of Non-curative Gastrectomy for Gastric Cancer: An Analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The surgical care of patients with metastatic gastric cancer (GC) remains debated. Despite level 1 evidence showing lack of survival benefit, surgery may be used for symptoms prevention or palliation. This study examined short-term postoperative outcomes of non-curative gastrectomy performed for metastatic GC.

Methods

A multi-institutional retrospective cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) registry, including gastrectomies for GC (2007–2015). The primary outcome was 30-day major morbidity. Multivariable analysis examined the association between metastatic status and outcomes adjusted for relevant demographic and clinical covariates.

Results

Of 5341 patients, 377 (7.1%) had metastases. Major morbidity was more common with metastases (29.4 vs. 19.6%; p < 0.001), driven by a higher rate of respiratory events. Prolonged hospital length of stay (beyond the 75th percentile: 11 days) was more likely with metastases than with no metastases (41.9 vs. 28.3%; p < 0.001). After adjustment, metastatic status was associated with major morbidity (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.16–1.90). This association remained for respiratory events (OR, 1.58; 95% CI, 1.07–2.33), 30-day mortality (OR, 2.19; 95% CI, 1.38–3.48), and prolonged hospital stay (OR, 1.65; 95% CI, 1.31–2.07).

Conclusion

Non-curative gastrectomy for metastatic GC was associated with significant major morbidity and mortality as well as a prolonged hospital stay, longer than expected for gastrectomy for non-metastatic GC. These data can inform decision making regarding non-curative gastrectomy, helping surgeons to weigh the risks of morbidity against the potential benefits and alternative therapeutic options.

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Author information

Authors and Affiliations

  1. Department or Surgery, University of Toronto, Toronto, ON, Canada

    Yunni Jeong MD, Natalie G. Coburn MD, MPH, Christopher J. Wallis MD, MSC, Paul J. Karanicolas MD, PhD, Calvin H. L. Law MD, MPH & Julie Hallet MD, MSc

  2. Sunnybrook Research Institute, Toronto, ON, Canada

    Yunni Jeong MD, Natalie G. Coburn MD, MPH, Kaitlyn Beyfuss MSc(c), Paul J. Karanicolas MD, PhD, Calvin H. L. Law MD, MPH & Julie Hallet MD, MSc

  3. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada

    Yunni Jeong MD, Natalie G. Coburn MD, MPH & Paul J. Karanicolas MD, PhD

  4. Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, MB, Canada

    Alyson L. Mahar PhD

  5. Division of General Surgery, Odette Cancer Centre–Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Natalie G. Coburn MD, MPH, Paul J. Karanicolas MD, PhD, Calvin H. L. Law MD, MPH & Julie Hallet MD, MSc

  6. Division of Urology, Houston Methodist, Houston, TX, USA

    Raj Satkunasivam MD, MSc

Authors
  1. Yunni Jeong MD
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  2. Alyson L. Mahar PhD
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  3. Natalie G. Coburn MD, MPH
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  8. Calvin H. L. Law MD, MPH
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  9. Julie Hallet MD, MSc
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Corresponding author

Correspondence to Julie Hallet MD, MSc.

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NSQIP disclosure

The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) and the hospitals participating in the ACS-NSQIP are the source of the data used in this report. They have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

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Jeong, Y., Mahar, A.L., Coburn, N.G. et al. Outcomes of Non-curative Gastrectomy for Gastric Cancer: An Analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). Ann Surg Oncol 25, 3943–3949 (2018). https://doi.org/10.1245/s10434-018-6824-8

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  • DOI: https://doi.org/10.1245/s10434-018-6824-8

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