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Oncotype DX® Recurrence Score as a Predictor of Response to Neoadjuvant Chemotherapy

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The Oncotype DX® assay has been validated in predicting response to adjuvant chemotherapy in breast cancer. Its role in neoadjuvant chemotherapy (NCT) has not been established.

Methods

The National Cancer Database was used to identify all patients with T1–T3, ER-positive, HER2-negative primary invasive breast cancer diagnosed from 2010 to 2015 who had Oncotype DX recurrence scores (RS) and received NCT. RS were classified as low, intermediate, or high. Unadjusted and adjusted regression analyses were performed to determine the association between pathologic complete response (pCR) and RS.

Results

A total of 989 patients (mean age, 54.6 years) with available RS who underwent NCT were identified. RS were low in 227 (23.0%) patients, intermediate in 450 (45.5%) patients, and high in 312 (31.5%) patients. Most patients had a T1 (431 [43.6%]) or T2 tumor (451 [45.6%]). Most had N0 disease (757 [76.5%]). Tumor grades were 1 (123 [12.4%]), 2 (517 [52.3%]), or 3 (349 [35.3%]). pCR was achieved by 42 (4.3%) patients. Adjusted multivariable analysis showed a significant association between pCR and high RS (odds ratio 4.87; 95% confidence interval 2.01–11.82).

Conclusions

High Oncotype DX RS was associated with pCR after NCT in this national cohort of ER-positive, HER2-negative patients. Oncotype DX testing could help to identify patients most suited for NCT and should be considered for incorporation into the multidisciplinary decision-making process.

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Acknowledgement

The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methodology employed or the conclusions drawn from these data by the investigator.

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Authors and Affiliations

  1. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Alison M. Pease MD

  2. Department of Surgery/Linsey BreastCare Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Luis A. Riba MD, Ryan A. Gruner MD & Ted A. James MD, MHCM

  3. Department of Medicine/Division of Hematology – Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Nadine M. Tung MD

Authors
  1. Alison M. Pease MD
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  2. Luis A. Riba MD
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  3. Ryan A. Gruner MD
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  4. Nadine M. Tung MD
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  5. Ted A. James MD, MHCM
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Corresponding author

Correspondence to Ted A. James MD, MHCM.

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Pease, A.M., Riba, L.A., Gruner, R.A. et al. Oncotype DX® Recurrence Score as a Predictor of Response to Neoadjuvant Chemotherapy. Ann Surg Oncol 26, 366–371 (2019). https://doi.org/10.1245/s10434-018-07107-8

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  • DOI: https://doi.org/10.1245/s10434-018-07107-8

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