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Starting a Radioactive Seed Localization Program

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Because of disadvantages, such as the need to perform the localization and operation the same day and difficulty maintaining orientation of the center of the localization in relation to the margins of excision, alternatives to wire localization for surgery of nonpalpable breast lesions have been widely pursued. Radioactive seed localization (RSL) is one technique that has gained acceptance in many practices throughout the world and has been shown to be a safe, effective alternative to wire localization. RSL allows the localization procedure to be scheduled on a different day from the operative procedure, the operative incision to be planned with no regard for the entry point used for localization, and ongoing feedback as to the location of and distance from the lesion throughout the operation. Although RSL is an attractive technique that is intuitive to learn, beginning a new RSL program entails a multidisciplinary effort that includes several challenges. We describe recommendations for how to start a RSL program.

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References

  1. Dauway EL, Saunders R, Friedland J. Innovative diagnostics for breast cancer: new frontiers for the new millennium using radioactive seed localization. In: Surgical forum: 85th annual American college of surgeons clinic congress, vol. 50. Chicago: American College of Surgeons; 1999.

  2. Gray RJ, Salud C, Nguyen K, et al. Randomized prospective evaluation of a novel technique for biopsy or lumpectomy of nonpalpable breast lesions: radioactive seed versus wire localization. Ann Surg Oncol. 2001;8(9):711–5

    Article  CAS  PubMed  Google Scholar 

  3. Gray RJ, Pockaj BA, Karstaedt PJ, et al. Radioactive seed localization of nonpalpable breast lesions is better than wire localization. Am J Surg. 2004;188(4):377–80.

    Article  PubMed  Google Scholar 

  4. Hughes JH, Mason MC, Gray RJ, et al. A multi-site validation trial of radioactive seed localization as an alternative to wire localization. Breast J. 2008;14(2):153–7.

    Article  PubMed  Google Scholar 

  5. Barentsz MW, Van Den Bosch MAAJ, Veldhuis WB, et al. Radioactive seed localization for non-palpable breast cancer. Br J Surg. 2013;100(5):582–8.

    Article  CAS  PubMed  Google Scholar 

  6. Cox CE, Furman B, Stowell N, et al. Radioactive seed localization breast biopsy and lumpectomy: can specimen radiographs be eliminated? Ann Surg Oncol. 2003;10(9):1039–47.

    Article  PubMed  Google Scholar 

  7. Gobardhan PD, de Wall LL, van der Laan L, et al. The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy. Ann Oncol. 2013;24(3):668–73.

    Article  CAS  PubMed  Google Scholar 

  8. Lovrics PJ, Goldsmith CH, Hodgson N, et al. A multicentered, randomized, controlled trial comparing radioguided seed localization to standard wire localization for nonpalpable, invasive and in situ breast carcinomas. Ann Surg Oncol. 2011;18(12):3407–14.

    Article  PubMed  Google Scholar 

  9. Murphy JO, Moo T-A, King TA, et al. Radioactive seed localization compared to wire localization in breast-conserving surgery: initial 6-month experience. Ann Surg Oncol. 2013;20(13):4121–7.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Van Riet YE, Jansen FH, van Beek M, et al. Localization of non-palpable breast cancer using a radiolabelled titanium seed. Br J Surg Soc. 2010;97:1240–5.

    Article  Google Scholar 

  11. Donker M, Drukker CA, Valdés Olmos RA, et al. Guiding breast-conserving surgery in patients after neoadjuvant systemic therapy for breast cancer: a comparison of radioactive seed localization with the ROLL technique. Ann Surg Oncol. 2013;20(8):2569–75.

    Article  PubMed  Google Scholar 

  12. Pavlicek W, Walton HA, Karstaedt PJ, Gray RJ. Radiation safety with use of I-125 seeds for localization of nonpalpable breast lesions. Acad Radiol. 2006;13(7):909–15. doi:10.1016/j.acra.2006.03.017

  13. Graham RP, Jakub JW, Brunette JJ, Reynolds C. Handling of radioactive seed localization breast specimens in the pathology laboratory. Am J Surg Pathol. 2012;36(11):1718–23.

    Article  PubMed  Google Scholar 

  14. Chiu JC, Ajmal S, Zhu X, Griffith E, Encarnacion T, Barr L. Radioactive seed localization of nonpalpable breast lesions in an academic comprehensive cancer program community hospital setting. Am Surg, 2014;80(7):675–9.

    PubMed  Google Scholar 

  15. Sharek D, Zuley ML, Zhang JY, Soran A, Ahrendt GM, Ganott MA. Radioactive seed localization versus wire localization for lumpectomies: a comparison of outcomes. Am J Roentgenol, 2015;204(4):872–7.

    Article  Google Scholar 

  16. Rao R, Moldrem A, Sarode V, White J, Amen M, Rao M, Andrews V, Euhus D, Radford L, Ulissey M. Experience with seed localization for nonpalpable breast lesions in a public health care system. Ann Surg Oncol. 2010;17(12):3241–6.

    Article  PubMed  Google Scholar 

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Correspondence to James Jakub MD, FACS or Richard Gray MD, FACS.

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Jakub, J., Gray, R. Starting a Radioactive Seed Localization Program. Ann Surg Oncol 22, 3197–3202 (2015). https://doi.org/10.1245/s10434-015-4719-5

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  • DOI: https://doi.org/10.1245/s10434-015-4719-5

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