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Taste Mask, Design and Evaluation of an Oral Formulation Using Ion Exchange Resin as Drug Carrier

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Abstract

The purpose of this research was to mask the bitter taste of Diphenhydramine Hydrochloride (DPH) using cation exchange resins. Indion 234 and Tulsion 343 that contained crosslinked polyacrylic backbone were used. The drug resin complexes (DRC) were prepared by batch process by taking drug: resin ratios 1:1, 1:2, and 1:3. The optimum drug: resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, micromeritic properties drug release and X-ray diffraction (PXRD). Effervescent and dispersible tablets were developed from optimum drug: resin ratios of 1:2 and 1:1. The formulations were evaluated for uniformity of dispersion, disintegration time, and in vitro dissolution. The X-ray diffraction study confirmed the monomolecularity of entrapped drug in the resin beads. The taste evaluation depicted the successful taste masking of DPH with drug resin complexes. The drug release of 95% in 15 min was observed for effervescent and dispersible tablets.

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Acknowledgement

The authors are thankful to Supriya Chemical Limited (Mumbai, India), Ion Exchange Limited (Mumbai, India), Thermax Limited (Pune, India) and Libra chemicals (Mumbai, India) for supplying gift sample of Diphenhydramine Hydrochloride, Indion resins, Tulsion resins, micro crystalline cellulose (Avicel PH 101) and polyvinlypyrolidone K-30. The authors also acknowledge to Faculty of Physics, Pune University (Pune, India) for the facility of PXRD.

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  1. Pharmaceutics, M.C.E. Society’s Allana College of Pharmacy, 2390 B-K.B. Hidayatullah Road, Azam campus, camp, Pune, Maharastra, 411001, India

    Kiran Bhise, Shafi Shaikh & Divyakumar Bora

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  1. Kiran Bhise
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  2. Shafi Shaikh
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  3. Divyakumar Bora
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Correspondence to Kiran Bhise.

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Bhise, K., Shaikh, S. & Bora, D. Taste Mask, Design and Evaluation of an Oral Formulation Using Ion Exchange Resin as Drug Carrier. AAPS PharmSciTech 9, 557–562 (2008). https://doi.org/10.1208/s12249-008-9056-6

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