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Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

The quantitative immunofluorescence assay of serous ovarian cancer tissue for the expression of estrogen receptors (ERα and ERβ) revealed a higher expression level of ERβ in comparison with ERα in all surgical tumor samples investigated. Significant differences in the expression level of the markers were detected “from tumor to tumor.” A high expression level of both ERα (≥ 25%) and ERβ (≥ 44%) in the tumor predicts a significantly longer progression-free survival time (p < 0.01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.

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Authors and Affiliations

  1. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478, Russia

    T. A. Bogush, A. A. Basharina, E. A. Bogush, O. M. Ryabinina, A. S. Tjulandina & S. A. Tjulandin

  2. Faculty of Fundamental Medicine, Moscow State University, Moscow, 119192, Russia

    A. A. Basharina

Authors
  1. T. A. Bogush
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  2. A. A. Basharina
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  3. E. A. Bogush
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  4. O. M. Ryabinina
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  5. A. S. Tjulandina
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  6. S. A. Tjulandin
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Corresponding author

Correspondence to T. A. Bogush.

Additional information

Original Russian Text © T.A. Bogush, A.A. Basharina, E.A. Bogush, O.M. Ryabinina, A.S. Tjulandina, S.A. Tjulandin, 2018, published in Doklady Akademii Nauk, 2018, Vol. 482, No. 3.

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Bogush, T.A., Basharina, A.A., Bogush, E.A. et al. Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis. Dokl Biochem Biophys 482, 249–251 (2018). https://doi.org/10.1134/S1607672918050058

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  • DOI: https://doi.org/10.1134/S1607672918050058

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