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Structural and functional analyses of the sixth site of neurexin alternative splicing

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

In this study, we found the sixth site of alternative splicing (SS6) of neurexin 1a from the rat brain. This site is located between the fifth LNS and the third EGF-like domains. The insertion in the SS6 site corresponds to the 9-residue peptide VALMKADLQ, which is conserved among animals. We demonstrated that the SS6 insertion regulates tissue-specific expression of neurexin 1α.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    O. V. Serova, D. M. Shayahmetova, I. E. Deyev & A. G. Petrenko

  2. Paris Cardiovascular Research Center, Paris, F-75015, France

    N. V. Radionov

Authors
  1. O. V. Serova
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  2. N. V. Radionov
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  3. D. M. Shayahmetova
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  4. I. E. Deyev
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  5. A. G. Petrenko
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Corresponding author

Correspondence to O. V. Serova.

Additional information

Original Russian Text © O.V. Serova, N.V. Radionov, D.M. Shayahmetova, I.E. Deyev, A.G. Petrenko, 2015, published in Doklady Akademii Nauk, 2015, Vol. 463, No. 4, pp. 487–490.

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Serova, O.V., Radionov, N.V., Shayahmetova, D.M. et al. Structural and functional analyses of the sixth site of neurexin alternative splicing. Dokl Biochem Biophys 463, 239–242 (2015). https://doi.org/10.1134/S1607672915040110

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  • DOI: https://doi.org/10.1134/S1607672915040110

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