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One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using Catalytic System NaOH‒DMSO

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Abstract

One-pot convenient process was developed for the production of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with anhydrides or acyl chlorides in a system NaOH‒DMSO. The reaction proceeds at room temperature with high yields.

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Author information

Authors and Affiliations

  1. Transfer Center of Pharmaceutical Technology, Ushinski Yaroslavl State Pedagogical University, Yaroslavl, 150000, Russia

    V. E. Pankrat’eva & T. V. Sharonova

  2. Yaroslavl State Technical University, Moskovskii pr. 88, Yaroslavl, 150023, Russia

    M. V. Tarasenko & E. R. Kofanov

  3. St. Petersburg State University, St. Petersburg, 199034, Russia

    S. V. Baikov

Authors
  1. V. E. Pankrat’eva
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  2. T. V. Sharonova
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  3. M. V. Tarasenko
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  4. S. V. Baikov
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  5. E. R. Kofanov
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Corresponding author

Correspondence to M. V. Tarasenko.

Additional information

Original Russian Text © V.E. Pankrat’eva, T.V. Sharonova, M.V. Tarasenko, S.V. Baikov, E.R. Kofanov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 8, pp. 1236–1241.

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Pankrat’eva, V.E., Sharonova, T.V., Tarasenko, M.V. et al. One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using Catalytic System NaOH‒DMSO. Russ J Org Chem 54, 1250–1255 (2018). https://doi.org/10.1134/S1070428018080213

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  • DOI: https://doi.org/10.1134/S1070428018080213

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