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Novel approach to the synthesis of istaroxime

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Abstract

Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.

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Authors and Affiliations

  1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632, China

    G.-P. Liang, J.-H. Guo & R.-W. Jiang

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  1. G.-P. Liang
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  2. J.-H. Guo
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  3. R.-W. Jiang
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Correspondence to R.-W. Jiang.

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The text was submitted by the authors in English.

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Liang, GP., Guo, JH. & Jiang, RW. Novel approach to the synthesis of istaroxime. Russ J Gen Chem 87, 2643–2647 (2017). https://doi.org/10.1134/S1070363217110196

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  • DOI: https://doi.org/10.1134/S1070363217110196

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