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Ultrasound-assisted synthesis of pyrazolo[1,2-b]phthalazines and dihydrospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazines] using TBAF as an efficient phase-transfer catalyst

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Abstract

Tetrabutylammonim fluoride has been used as an efficient catalyst for synthesis of pyrazolo[1,2-b]-phthalazine-5,10-diones and dihydrospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazines] by one-pot three-component reaction of phthalhydrazide, aromatic aldehydes or isatin derivatives, with malononitrile in water under ultrasond irradiation. This rapid method gave the products in high yield.

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Authors and Affiliations

  1. Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

    H. Kefayati, A. Delafrooz & S. Homayoon

Authors
  1. H. Kefayati
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  2. A. Delafrooz
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  3. S. Homayoon
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Correspondence to H. Kefayati.

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Kefayati, H., Delafrooz, A. & Homayoon, S. Ultrasound-assisted synthesis of pyrazolo[1,2-b]phthalazines and dihydrospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazines] using TBAF as an efficient phase-transfer catalyst. Russ J Gen Chem 86, 1735–1740 (2016). https://doi.org/10.1134/S107036321607032X

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  • DOI: https://doi.org/10.1134/S107036321607032X

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