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Supramolecular agents for theranostics

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Abstract

This mini-review summarizes recent data obtained in the process of creation of a versatile modular platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different natures (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphors, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for the creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.

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Abbreviations

ASBB:

adapter system barnase:barstar

QD:

quantum dots

LND:

luminescent nanodiamonds

MMP:

magnetic microparticles

MNP:

magnetic nanoparticles

UCNP:

upconversion nanophosphors (or anti-Stokes nanophosphors)

4D5scFv:

single-chain variable fragment of antibody 4D5

ETA:

bacterial exotoxin A

HER2/neu:

cell transmembrane receptor of the family of the human tyrosin kinase receptor ErbB (HER1–4)

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russia

    S. M. Deyev & E. N. Lebedenko

  2. Lobachevsky State University of Nizhny Novgorod, pr. Gagarina, 23, Nizhny Novgorod, 603950, Russia

    S. M. Deyev

Authors
  1. S. M. Deyev
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  2. E. N. Lebedenko
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Correspondence to E. N. Lebedenko.

Additional information

The article was translated by the authors.

The article is published following the plenary lecture at the VII Russian Symposium “Proteins and Peptides;” Novosibirsk, July 12–17, 2015.

Original Russian Text © S.M. Deyev, E.N. Lebedenko, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 5, pp. 539–552.

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Deyev, S.M., Lebedenko, E.N. Supramolecular agents for theranostics. Russ J Bioorg Chem 41, 481–493 (2015). https://doi.org/10.1134/S1068162015050052

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