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Poised RNA polymerase II and master regulation in Metazoa

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Abstract

In this review, we discuss mechanisms of the transcription pausing of RNA polymerase II and its poised state. The important features of poised promoters and chromatin are briefly described. The role of transcription pausing as a discrete and important stage in the regulation of expression of master genes, which control stem-cell differentiation, cell lineage and development in Metazoa, are discussed.

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Abbreviations

PolII:

RNA polymerase II

TSS:

transcription start site

ESCs:

embryonic stem cells

CTD:

C-terminal domain of RNA polymerase II

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    K. N. Kashkin & E. D. Sverdlov

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  1. K. N. Kashkin
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  2. E. D. Sverdlov
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Correspondence to K. N. Kashkin.

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Original Russian Text © K.N. Kashkin, E.D. Sverdlov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 6, pp. 905–914.

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Kashkin, K.N., Sverdlov, E.D. Poised RNA polymerase II and master regulation in Metazoa. Mol Biol 49, 810–817 (2015). https://doi.org/10.1134/S0026893315060114

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  • DOI: https://doi.org/10.1134/S0026893315060114

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