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Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease

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Abstract

Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including translation initiation machinery. This review is dedicated to the mitochondrial translation initiation factor 3 (IF3mt), which plays a key role in the protein synthesis in mitochondria. Involvement of IF3mt in human health and disease is discussed.

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Abbreviations

CTD:

C-terminal domain

CTE:

C-terminal extension

fMet:

formylmethionine

IF3mt:

mitochondrial translation initiation factor 3

LSU:

large subunit

NC:

normal chow

NTD:

N-terminal domain

NTE:

N-terminal extension

PA:

physically active

PD:

Parkinson’s disease

SED:

sedentary

SSU:

small subunit

TACO1:

translational activator of cytochrome c oxidase 1

TUFM:

thermo-unstable elongation factor, mitochondrial

WD:

Western diet

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Funding

The work was funded by the Russian Science Foundation (project 18-74-00016); the work of E.B.D. was financially supported by the State Basic Research Program no. 0108-2019-004 for the Institute of Developmental Biology, Russian Academy of Sciences.

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Authors and Affiliations

  1. Faculty of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia

    I. V. Chicherin, M. V. Baleva, S. A. Levitskii & I. A. Krasheninnikov

  2. Institute of Functional Genomics, Lomonosov Moscow State University, 119234, Moscow, Russia

    I. V. Chicherin

  3. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    E. B. Dashinimaev

  4. Pirogov Russian National Research Medical University, 117977, Moscow, Russia

    E. B. Dashinimaev

Authors
  1. I. V. Chicherin
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  2. M. V. Baleva
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  3. S. A. Levitskii
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  4. E. B. Dashinimaev
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  5. I. A. Krasheninnikov
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Correspondence to I. V. Chicherin.

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Conflict of interest. The authors declare no conflict of interest.

Compliance with ethical standards. This article does not contain description of studies involving animals or human participants performed by any of the authors.

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Published in Russian in Biokhimiya, 2019, Vol. 84, No. 10, pp. 1401-1409

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Chicherin, I.V., Baleva, M.V., Levitskii, S.A. et al. Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease. Biochemistry Moscow 84, 1143–1150 (2019). https://doi.org/10.1134/S0006297919100031

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