Abstract
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106–1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221–1.769, P < .001).
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This work was supported by NINDS grant 1U54NS43049 with additional support from P20 RR11091 (NCRR), RCMI grant G12 RR/AI 03061 (NCRR), and the Hawaii Medical Student Aging Research National Training Center (NIA, John A. Hartford Foundation, and AFAR grant) (P.Y.).
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Valcour, V., Yee, P., Williams, A.E. et al. Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection—The Hawaii Aging with HIV Cohort. Journal of NeuroVirology 12, 387–391 (2006). https://doi.org/10.1080/13550280600915339
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DOI: https://doi.org/10.1080/13550280600915339