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Human Herpesvirus 8 in Hematologic Diseases

  • Published:
Pathology & Oncology Research

Abstract

Human herpesvirus type 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV) is a new member of the γ-herpesvirus family. It is an unusual herpesvirus in that it carries a large number of genes that encode oncoproteins or cell signaling proteins. In addition to being the causative agent of both HIV-associated and non-HIV-associated Kaposi’s sarcoma this DNA tumor virus has been implicated in the pathogenesis of several diseases. These include multiple myeloma (MM), Waldenström’s macroglobulinemia (WM), multicentric Castleman’s disease (MCD), body cavity-based lymphoma (BCBL), and various other conditions such as sarcoidosis and pemphigus. While the causative role of the viral infection is fairly certain in the development of BCBL and multicentric Castleman’s disease, HHV-8 may act through a different mechanism to induce plasma cell malignancies. It has been suggested - though the finding is still controversial -that infection of bone marrow stromal dendritic cells by HHV-8 might be a key factor in the etiology and pathogenesis of monoclonal gammopathies. The aim of this review is to provide a short introduction into the tumorigenic potential of HHV-8 as well as to detail the available data and possible mechanisms on the involvement of this virus in different hematologic diseases.

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Authors and Affiliations

  1. First Department of Internal Medicine, Imre Haynal University of Health Sciences, Szabolcs u. 35, H-1135, Budapest, Hungary

    Gábor Mikala, Gyula DomjÁn & István VÁlyi-Nagy

  2. Béla Johan National Center for Epidemiology, Gyáli út 2-6, H-1097, Budapest

    Jiuru Xie & György Berencsi

  3. Department of Pediatrics, University Medical School of Debrecen, Nagyerdei krt. 98, H-4012, Debrecen

    Csongor Kiss

  4. Department of Stomatology, University Medical School of Debrecen, Nagyerdei krt. 98, H-4012, Debrecen, Hungary

    Ildikó MÁrton

Authors
  1. Gábor Mikala
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  2. Jiuru Xie
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  3. György Berencsi
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  4. Csongor Kiss
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  5. Ildikó MÁrton
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  6. Gyula DomjÁn
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  7. István VÁlyi-Nagy
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Additional information

This work was supported in part by grants from the “Hungarian National Science Foundation (OTKA T 016978) the Hungarian Ministry of Welfare (ETT T05 263/96), and FNK (HIETE, Budapest)

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Mikala, G., Xie, J., Berencsi, G. et al. Human Herpesvirus 8 in Hematologic Diseases. Pathol. Oncol. Res. 5, 73–79 (1999). https://doi.org/10.1053/paor.1999.0073

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  • DOI: https://doi.org/10.1053/paor.1999.0073

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