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Synthesis and Antiviral Activity of Betulonic Acid Amides and Conjugates with Amino Acids

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Abstract

Betulonic acid amides with aliphatic and heterocyclic amines and with L-amino acids were synthesized by the acid chloride method. Betulonic acid amide and L-methionine derivatives of betulonic acid and its 3-oxime effectively inhibit the influenza A virus. Betulonic acid octadecylamide is active against the herpes simplex Type 1 virus. The conjugate of betulonic acid 3-oxime with L-methionine is also active toward HIV-1. The tested compounds mainly show no activity toward the ECHO6 virus, which is devoid of a coat.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    O. B. Flekhter, L. R. Nigmatullina, E. V. Tret'yakova, L. A. Baltina, F. Z. Galin & G. A. Tolstikov

  2. State Research Institute of Epidemiology and Microbiology, Minsk, Belarus

    E. I. Boreko, N. I. Pavlova, S. N. Nikolaeva, O. V. Savinova & V. F. Eremin

Authors
  1. O. B. Flekhter
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  2. E. I. Boreko
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  3. L. R. Nigmatullina
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  4. E. V. Tret'yakova
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  5. N. I. Pavlova
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  6. L. A. Baltina
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  7. S. N. Nikolaeva
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  8. O. V. Savinova
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  9. V. F. Eremin
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  10. F. Z. Galin
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  11. G. A. Tolstikov
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Corresponding author

Correspondence to O. B. Flekhter.

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Flekhter, O.B., Boreko, E.I., Nigmatullina, L.R. et al. Synthesis and Antiviral Activity of Betulonic Acid Amides and Conjugates with Amino Acids. Russian Journal of Bioorganic Chemistry 30, 80–88 (2004). https://doi.org/10.1023/B:RUBI.0000015778.77887.f1

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  • DOI: https://doi.org/10.1023/B:RUBI.0000015778.77887.f1

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