Abstract
Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO3-3Gal-ceramide) and seminolipid (SO3-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is expressed on the spermatogenic cells. Cerebroside sulfotransferase (CST)-deficient mice generated by gene targeting completely lack sulfatide and seminolipid all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte terminal differentiation, and an arrest of spermatogenesis, indicating that sulfation of glycolipids is essential for myelin formation and spermatogenesis. Moreover, CST-deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction, an experimental model of renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin. Studies on the molecular mechanisms by which sulfoglycolipids participate in these biological processes are ongoing. Published in 2004.
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References
Ishizuka I, Chemistry and functional distribution of sulfoglycol-ipids, Prog Lipid Res 36, 245–319 (1997).
Vos JP, Lopes-Cardozo M, Gadella BM, Metabolic and functional aspects of sulfogalactolipids, Biochim Biophys Acta 1211, 125–49 (1994).
Schulte S, Stoffel W, Ceramide UDP-galactosyltransferase from myelinating rat brain: Purification, cloning, and expression, Proc Natl Acad Sci USA 90, 10265–9 (1993).
Honke K, Yamane M, Ishii A, Kobayashi T, Makita A, Purification and characterization of 3-phosphoadenosine-5-phosphosulfate: GalCer sulfotransferase from human renal cancer cells, J Biochem 119, 421–7 (1996).
Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y, Molecular cloning and expression of cDNA encoding human 3-phosphoadenylylsulfate: Galactosylceramide 3-sulfotransferase, J Biol Chem 272, 4864–8 (1997).
Bosio A, Binczek E, Stoffel W, Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis, Proc Natl Acad Sci USA 93, 13280–5 (1996).
Coetzee T, Fujita N, Dupree J, Shi R, Blight A, Suzuki K, Suzuki K, Popko B, Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability, Cell 86, 209–19 (1996).
Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y, Taniguchi N, Paranodal junction formation and spermatogenesis re-quire sulfoglycolipids, Proc Natl Acad Sci USA 99, 4227–32 (2002).
Hirahara Y, Tsuda M, Wada Y, Honke K, cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase, Eur J Biochem 267, 1909–17 (2000).
Girault JA, Peles E, Development of nodes of Ranvier, Curr Opin Neurobiol 12, 476–85 (2002).
Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B, Myelin galac-tolipids are essential for proper node of Ranvier formation in the CNS, J Neurosci 18, 1642–9 (1998).
Ishibashi T, Dupree JL, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Suzuki K, Nishino H, Baba H, A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myeli-nated axon but not essential for initial cluster formation, J Neurosci 22, 6507–14 (2002).
Dupree JL, Girault JA, Popko B, Axo-glial interactions regulate the localization of axonal paranodal proteins, J Cell Biol 147, 1145–52 (1999).
Bansal R, Winkler S, Bheddah S, Negative regulation of oligo-dendrocyte differentiation by galactosphingolipids, J Neurosci 19, 7913–24 (1999).
Hirahara Y, Bansal R, Honke K, Ikenaka K, Wada Y, Sulfatide is a negative regulator of oligodendrocyte differentiation: Develop-ment in sulfatide-mull mice, Glia 45, 269–77 (2004).
Brinster RL, Germline stem cell transplantation and transgenesis, Science 296, 2174–6 (2002).
Fujimoto H, Tadano-Aritomi K, Tokumasu A, Ito K, Hikita T, Suzuki K, Ishizuka I, Requirement of seminolipid in spermatoge-nesis revealed by UDP-galactose: Ceramide galactosyltransferase-deficient mice, J Biol Chem 275, 22623–6 (2000).
Shikata K, Suzuki Y, Wada J, Hirata K, Matsuda M, Kawashima H, Suzuki T, Iizuka M, Makino H, Miyasaka M, L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction, J Pathol 188, 93–9 (1999).
Suzuki Y, Toda Y, Tamatani T, Watanabe T, Suzuki T, Nakao T, Murase K, Kiso M, Hasegawa A, Tadano-Aritomi K, Ishizuka I, Miyasaka M, Sulfated glycolipids are ligands for a lymphocyte homing receptor, L-selectin (LECAM-1), Binding epitope in sulfated sugar chain, Biochem Biophys Res Commun 190, 426–34 (1993).
Ogawa D, Shikata K, Honke K, Sato S, Matsuda M, Nagase R, Tone A, Okada S, Usui H, Wada J, Miyasaka M, Kawashima H, Suzuki Y, Suzuki T, Taniguchi N, Hirahara Y, Tadano-Aritomi K, Ishizuka I, Tedder TF, Makino H, Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction, J Biol Chem 279, 2085–90 (2004).
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Honke, K., Zhang, Y., Cheng, X. et al. Biological roles of sulfoglycolipids and pathophysiology of their deficiency. Glycoconj J 21, 59–62 (2004). https://doi.org/10.1023/B:GLYC.0000043749.06556.3d
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DOI: https://doi.org/10.1023/B:GLYC.0000043749.06556.3d