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Age-specific survival after Hodgkin's disease in a population-based cohort (United States)

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Abstract

Objective: To examine risk factors for disease-specific survival in young and older adults diagnosed with Hodgkin's disease (HD) in a representative case series of adequate size for detecting effect modification by age group.

Methods: For 5630 young adults (ages 15–44) and 2424 older adults (ages 45 and older) diagnosed with HD and reported to the population-based Surveillance, Epidemiology, and End Results program of the National Cancer Institute between 1983 and 1995, Kaplan–Meier survival curves were constructed and Cox proportional hazards regression used to evaluate the influences of age, sex, race/ethnicity, histologic subtype, Ann Arbor stage at diagnosis, and calendar year on hazard of disease-specific death.

Results: The effects of most previously studied risk factors for HD death were different for young and older adults. Age was not associated with disease-specific survival in young adults, but in older adults, 1-year increases in age elevated the relative hazard of HD death by 4–6%. Male sex was related to outcome in young but not older adults, and Ann Arbor stage and B-symptom status exhibited markedly different relationships to survival by age. Older adult patients with and without B-symptoms had different hazards of mortality and had to be assessed separately.

Conclusions: Factors associated with disease-specific survival were different for young and older adults with HD. These findings provide further support for two etiologically and clinically distinct disease entities.

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Authors and Affiliations

  1. Surveillance Research, Northern California Cancer Center, 32690 Alvarado Niles Road, #600, Union City, CA, 94587, USA

    Christina A. Clarke, Sally L. Glaser & Angela W. Prehn

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  1. Christina A. Clarke
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  2. Sally L. Glaser
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  3. Angela W. Prehn
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Clarke, C.A., Glaser, S.L. & Prehn, A.W. Age-specific survival after Hodgkin's disease in a population-based cohort (United States). Cancer Causes Control 12, 803–812 (2001). https://doi.org/10.1023/A:1012240222032

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