References
Harker LA, Hanson SR, Runge MS. Thrombin hypothesis of thrombus generation and vascular lesion formation. Am J Cardiol 1995;75:12B-17B.
Cannon CP, McCabe CH, Henry TD, et al. for the TIMI 5 Investigators. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial. J Am Coll Cardiol 1994;23:993–1003.
Lee LV for the TIMI 6 Investigators. Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial. Am J Cardiol 1995;75:7–13.
Neuhaus KL, Niederer W, Wagner J, et al. for the ALKKStudy Group. HIT (Hirudin for the Improvement of Thrombolysis): Results of a dose escalation study. Circulation 1993;88:I-292.
Antman EM, for the TIMI 9B Investigators. Hirudin in acute myocardial infarction: Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation 1996;94:911–921.
The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators: A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996;335:775–782.
Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest 1990; 86:385–391.
Zoldhelyi P, Janssens S, Lefevre G, Collen D, Van de Werf F, for the GUSTO-2A Investigators: Effects of heparin and hirudin (CGP 39393) on thrombin generation during thrombolysis for acute myocardial infarction. Circulation 1995;92: I-740.
Rao AK, Sun L, Chesebro JH, et al. for Hirudin in Unstable Angina Trial. Distinct effects of recombinant desulfatohirudin (CGP 39,393) and heparin on plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in unstable angina: A multicenter trial. Thromb Haemost 1995;73:1306 (Abstr).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giugliano, R.P., Antman, E.M. & Braunwald, E. Reexamination of the Thrombin Hypothesis: What We Have Learned from TIMI 9B and GUSTO IIb. J Thromb Thrombolysis 4, 321–323 (1997). https://doi.org/10.1023/A:1008880829137
Issue Date:
DOI: https://doi.org/10.1023/A:1008880829137