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Phase II study of vinorelbine and ifosfamide in anthtracycline resistent metastatic breast cancer

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Abstract

The new combination of ifosfamide and vinorelbine wasevaluated in a phase II study of patientswith metastatic breast cancer. All the patients hadevaluable or measurable lesions resistant to the combinationof cyclophosphamide, epidoxorubicin and 5-fluorouracil. Out of 25patients entered the trial, 7 achieved an objectiveresponse (28%) (95% C.I. 12–49.3).Ten patients (40%) experienced stable disease andthe remaining patients (30%) progressive disease.The median time to progression was 4 months (range 2–12 +).The activity of the ifosfamide-vinorelbine combinationhas been demonstrated and the toxicity was acceptable.

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Authors and Affiliations

  1. Department of Medical Oncology, S. Andrea Hospital, La Spezia

    P. Pronzato, M. Landucci, F. Vaira & A. Vigani

  2. Department of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genova

    P. Queirolo

  3. Department of Surgical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

    M. Gipponi & F. Cafiero

Authors
  1. P. Pronzato
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  2. P. Queirolo
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  3. M. Landucci
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  4. F. Vaira
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  5. A. Vigani
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  6. M. Gipponi
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  7. F. Cafiero
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Pronzato, P., Queirolo, P., Landucci, M. et al. Phase II study of vinorelbine and ifosfamide in anthtracycline resistent metastatic breast cancer. Breast Cancer Res Treat 42, 183–186 (1997). https://doi.org/10.1023/A:1005720431557

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  • DOI: https://doi.org/10.1023/A:1005720431557

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