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“Petal effect”-inspired superhydrophobic and highly adhesive coating on magnesium with enhanced corrosion resistance and biocompatibility

仿花瓣效应超疏水涂层提高纯镁抗腐蚀性和生物相容性

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Abstract

With properties of complete degradation and favorable mechanical behavior, Mg and its alloys are regarded as the next generation medical metal materials. However, fast degradation and poor surface biocompatibility hinder their clinical applications. Inspired by the “petal effect”, we successfully constructed a superhydrophobic and highly adhesive coating on pure Mg via a simple hydrothermal treatment in a solution containing sodium oleate. The superhydrophobicity of the fabricated coating results from its flake-like micro-nanostructure and the low-surface-energy oleate group. Water droplet on the superhydrophobic coating cannot roll off even when the sample is turned upside down, owing to the sealed air-pockets and the van der Waals’ attraction at the solidliquid interface, indicating a highly adhesive force. The chemical and mechanical stability of the superhydrophobic coating were measured. Potentiodynamic polarization and electrochemical impedance spectroscopy measurements suggest enhanced corrosion resistance of the as-prepared sample. Furthermore, cell cytotoxicity, migration and adhesion data of human umbilical vein endothelial cells (HUVECs) reveal an improved cytocompatibility of the modified surface. Finally, hemolysis assay and platelet adhesion assay suggest an improved hemocompatibility. It is believed that the facile and low-cost method can expand the new application of superhydrophobic surface with highly adhesive on Mg in biomedical fields.

摘要

由于具有完全可降解性和良好的机械性能, 镁及其合金被誉为“下一代生物医用金属材料”. 然而, 过快的降解速率和较差的生物相容性制约着它们在临床上的应用. 受“花瓣效应”启发, 本文利用含有油酸钠的溶液, 通过水热法在纯镁表面制备了超疏水且具有高粘附力的涂层. 涂层表面的片状微纳结构和低表面自由能的油酸根赋予涂层超疏水性. 水滴与涂层表面之间封存的空气以及固液界面间的范德华力, 使水滴在涂层表面显示出高粘附性(即使倒置180°, 水滴也不会从材料表面脱落). 本工作评价了所制备超疏水涂层的化学稳定性和机械稳定性. 动电位极化曲线和阻抗谱测试都表明所制备涂层具有良好的抗腐蚀性. 此外, 细胞(人脐静脉内皮细胞)毒性、 细胞迁移以及细胞粘附等结果都表明超疏水涂层具有良好的细胞相容性. 最后, 溶血率和血小板粘附测试表明超疏水涂层的血液相容性也有明显提升. 利用超疏水高粘附力涂层改善纯镁抗腐蚀性和生物相容性的思路有望拓展镁在生物医用领域的应用.

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Acknowledgements

This work was financially supported by the Distinguished Young Scholars of China (51525207), the National Natural Science Foundation of China (31570973), the National Key Research and Development Program of China (2016YFC1100604), and Shanghai Committee of Science and Technology, China (15441904900).

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Authors and Affiliations

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China

    Feng Peng  (彭峰), Donghui Wang  (王东辉), Xiaohan Ma  (马小涵), Hongqin Zhu  (朱红芹), Yuqin Qiao  (乔玉琴) & Xuanyong Liu  (刘宣勇)

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Feng Peng  (彭峰) & Donghui Wang  (王东辉)

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  1. Feng Peng  (彭峰)
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  2. Donghui Wang  (王东辉)
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  3. Xiaohan Ma  (马小涵)
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  4. Hongqin Zhu  (朱红芹)
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  5. Yuqin Qiao  (乔玉琴)
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  6. Xuanyong Liu  (刘宣勇)
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Corresponding author

Correspondence to Xuanyong Liu  (刘宣勇).

Additional information

Peng Feng was born in 1992. He received his bachelor degree in materials science from the School of Materials Science and Engineering, Central South University, in 2014. He is now a doctoral candidate at Shanghai Institute of Ceramics Chinese Academy of Sciences, and his current research interest is focused on biodegradable magnesium alloys for biomedical application.

Liu Xuanyong was born in 1974. He received his BSc and MSc degrees in materials science and engineering from Hunan University in 1996 and 1999, respectively, and PhD in materials science and engineering from Shanghai Institute of Ceramics Chinese Academy of Sciences, in 2002. His research fields include nanosized and functionalized surface of biomedical Ti alloys, PEEK and biodegradable magnesium alloys, surface modification of biomaterials using plasma immersion ion implantation & deposition (PIII&D) technology, plasma sprayed bioactive ceramic coatings.

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40843_2017_9087_MOESM1_ESM.pdf

“Petal Effect”-Inspired Superhydrophobic and Highly Adhesive Coating on Magnesium with Enhanced Corrosion Resistance and Biocompatibility

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Peng, F., Wang, D., Ma, X. et al. “Petal effect”-inspired superhydrophobic and highly adhesive coating on magnesium with enhanced corrosion resistance and biocompatibility. Sci. China Mater. 61, 629–642 (2018). https://doi.org/10.1007/s40843-017-9087-2

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  • DOI: https://doi.org/10.1007/s40843-017-9087-2

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