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Impatient for Inpatient Sleep: Treating Sleep Disturbances in the Hospital Setting

  • Insomnia and Pharmacotherapy (H Attarian and M Kay-Stacey, Section Editors)
  • Published:
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Abstract

Purpose of Review

Disturbed sleep and sleep deprivation are common complaints among inpatients; however, limited research has targeted this population to investigate primary causes and solutions, and no comprehensive guidelines address this widespread problem.

Recent Findings

Many factors contribute to inpatient sleep difficulty. Key environmental sources are excess noise and light. The use of earplugs and eye masks are supported by some studies. Attempts to reduce disturbing light and noise on hospital units have been helpful. Schedule modifications that limit awakenings for measurements and medications also have been shown to be beneficial. Patients with inpatient sleep complaints are prescribed a wide range of medications, though little guidance is available to direct therapy with regard to pharmacodynamic and pharmacokinetic features, adverse event risks, and potential interactions.

Summary

A combination of environmental modifications and altered schedules for routine assessments, procedures, and treatments; individualized non-pharmacological interventions; and strategically chosen medications for selected patients should help minimize nighttime sleep disruption in hospitalized patients.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Lenhart SE, Buysse DJ. Treatment of insomnia in hospitalized patients. Ann Pharmacother. 2001;35(11):1449–57.

    Article  CAS  PubMed  Google Scholar 

  2. Young JS, Bourgeois JA, Hilty DM, Hardin KA. Sleep in hospitalized medical patients, part 1: factors affecting sleep. J Hosp Med. 2008;3(6):473–82.

    Article  PubMed  Google Scholar 

  3. Kahn-Greene ET, Killgore DB, Kamimori GH, Balkin TJ, Killgore WD. The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med. 2007;8(3):215–21.

    Article  PubMed  Google Scholar 

  4. Colten HR, Altevogt BM, editors. Sleep disorders and sleep deprivation: an unmet public health problem. Washington: The National Academic Press; 2006.

    Google Scholar 

  5. Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166(16):1756–62.

    Article  CAS  PubMed  Google Scholar 

  6. DePietro RH, Knutson KL, Spampinato L, Anderson SL, Meltzer DO, Van Cauter E, et al. Association between inpatient sleep loss and hyperglycemia of hospitalization. Diabetes Care. 2017;40(2):188–93.

    Article  PubMed  Google Scholar 

  7. Arora VM, Chang KL, Fazal AZ, Staisiunas PG, Meltzer DO, Zee PC, et al. Objective sleep duration and quality in hospitalized older adults: associations with blood pressure and mood. J Am Geriatr Soc. 2011;59(11):2185–6.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487–504.

    PubMed  PubMed Central  Google Scholar 

  9. American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.

    Google Scholar 

  10. • Grossman MN, Anderson SL, Worku A, Marsack W, Desai N, Tuvilleja A, et al. Awakenings? Patient and hospital staff perceptions of nighttime disruptions and their effect on patient sleep. J Clin Sleep Med. 2017;13(2):301–6. This recent article describes a standardized questionnaire study of perceptions by patients and hospital physicians and nurses regarding factors contributing to sleep disruption.

    Article  PubMed  PubMed Central  Google Scholar 

  11. American Psychiatric Association, editor. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.

    Google Scholar 

  12. Dobing S, Frolova N, McAlister F, Ringrose J. Sleep quality and factors influencing self-reported sleep duration and quality in the general internal medicine inpatient population. PLoS One. 2016;11(6):e0156735.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Locke CL, Pope DS. Assessment of medical-surgical patients’ perception of hospital noises and reported ability to rest. Clin Nurse Spec. 2017;31(5):261–7.

    Article  PubMed  Google Scholar 

  14. Bihari S, Doug McEvoy R, Matheson E, Kim S, Woodman RJ, Bersten AD. Factors affecting sleep quality of patients in intensive care unit. J Clin Sleep Med. 2012;8(3):301–7.

    PubMed  PubMed Central  Google Scholar 

  15. Ulrich JA. Sound Control for Improved Outcomes in Healthcare Settings. Concord: The Center for Health Design; 2007. https://www.healthdesign.org/sites/default/files/Sound%20Control.pdf.

  16. Busch-Vishniac IJ, West JE, Barnhill C, Hunter T, Orellana D, Chivukula R. Noise levels in Johns Hopkins Hospital. J Acoust Soc Am. 2005;118(6):3629–45.

    Article  PubMed  Google Scholar 

  17. Kawai Y, Weatherhead JR, Traube C, Owens TA, Shaw BE, Fraser EJ, et al. Quality improvement initiative to reduce pediatric intensive care unit noise pollution with the use of a pediatric delirium bundle. J Intensive Care Med. 2017. https://doi.org/10.1177/0885066617728030.

  18. Park MJ, Yoo JH, Cho BW, Kim KT, Jeong WC, Ha M. Noise in hospital rooms and sleep disturbance in hospitalized medical patients. Environ Health Toxicol. 2014;29:e2014006. https://doi.org/10.5620/eht.2014.29.e2014006.

  19. Kudchadkar SR, Beers MC, Ascenzi JA, Jastaniah E, Punjabi NM. Nurses’ perceptions of pediatric intensive care unit environment and work experience after transition to single-patient rooms. Am J Crit Care. 2016;25(5):e98–e107.

    Article  PubMed  Google Scholar 

  20. Shepley MM, Gerbi RP, Watson AE, Imgrund S, Sagha-Zadeh R. The impact of daylight and views on ICU patients and staff. HERD. 2012 Winter;5(2):46–60.

  21. Takaesu Y, Futenma K, Kobayashi M, Komada Y, Tanaka N, Yamashina A, et al. A preliminary study on the relationships between diurnal melatonin secretion profile and sleep variables in patients emergently admitted to the coronary care unit. Chronobiol Int. 2015;32(6):875–9.

    Article  CAS  PubMed  Google Scholar 

  22. Sun T, Han F, Sun Y, Liu J, Yang J, Wang X. Research of 24-hour dynamic sleep monitoring and melatonin changes in patients with delirium in intensive care unit. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014;26(10):726–9.

    PubMed  Google Scholar 

  23. Gehlbach BK, Chapotot F, Leproult R, Whitmore H, Poston J, Pohlman M, et al. Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation. Sleep. 2012;35(8):1105–14.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Christensen M, Dodds A, Sauer J, Watts N. Alarm setting for the critically ill patient: a descriptive pilot survey of nurses’ perceptions of current practice in an Australian Regional Critical Care Unit. Intensive Crit Care Nurs. 2014;30(4):204–10.

    Article  PubMed  Google Scholar 

  25. Buxton OM, Ellenbogen JM, Wang W, Carballeira A, O'Connor S, Cooper D, et al. Sleep disruption due to hospital noises: a prospective evaluation. Ann Intern Med. 2012;157(3):170–9.

    Article  PubMed  Google Scholar 

  26. Cooper AB, Thornley KS, Young GB, Slutsky AS, Stewart TE, Hanly PJ. Sleep in critically ill patients requiring mechanical ventilation. Chest. 2000;117(3):809–18.

    Article  CAS  PubMed  Google Scholar 

  27. Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 2001;163(2):451–7.

    Article  CAS  PubMed  Google Scholar 

  28. Kudchadkar SR, Aljohani OA, Punjabi NM. Sleep of critically ill children in the pediatric intensive care unit: a systematic review. Sleep Med Rev. 2014;18(2):103–10.

    Article  PubMed  Google Scholar 

  29. Kudchadkar SR, Yaster M, Punjabi AN, Quan SF, Goodwin JL, Easley RB, et al. Temporal characteristics of the sleep EEG power spectrum in critically ill children. J Clin Sleep Med. 2015;11(12):1449–54.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Gehlbach BK, Chapotot F, Leproult R, Whitmore H, Poston J, Pohlman M, et al. Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation. Sleep. 2012;35(8):1105–14.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Martin JL, Hakim AD. Wrist actigraphy. Chest. 2011;139(6):1514–27.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kamdar BB, Kadden DJ, Vangala S, Elashoff DA, Ong MK, Martin JL, et al. Feasibility of continuous actigraphy in patients in a medical intensive care unit. Am J Crit Care. 2017;26(4):329–35.

    Article  PubMed  Google Scholar 

  33. Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007;30(11):1445–59.

    Article  PubMed  PubMed Central  Google Scholar 

  34. van der Kooi AW, Tulen JH, van Eijk MM, de Weerd AW, van Uitert MJ, van Munster BC, et al. Sleep monitoring by actigraphy in short-stay ICU patients. Crit Care Nurs Q. 2013;36(2):169–73.

    Article  PubMed  Google Scholar 

  35. Hoey LM, Fulbrook P, Douglas JA. Sleep assessment of hospitalised patients: a literature review. Int J Nurs Stud. 2014;51(9):1281–8.

    Article  PubMed  Google Scholar 

  36. Richards KC, O’Sullivan PS, Phillips RL. Measurement of sleep in critically ill patients. J Nurs Meas. 2000 Fall-Winter;8(2):131–44.

  37. • Hu RF, Jiang XY, Chen J, Zeng Z, Chen XY, Li Y, et al. Non-pharmacological interventions for sleep promotion in the intensive care unit. Cochrane Database Syst Rev. 2015;(10): CD008808. https://doi.org/10.1002/14651858. This Cochrane meta-analysis of nonpharmacological strategies to promote sleep in ICU units found limited high-quality evidence, but is valuable in reviewing the diversity of the interventions that have been assessed.

  38. Machado FS, Souza RCDS, Poveda VB, Costa ALS. Non-pharmacological interventions to promote the sleep of patients after cardiac surgery: a systematic review. Rev Lat Am Enfermagem. 2017;25: e2926-8345.1917.2926. https://doi.org/10.1590/1518-8345.1917.2926.

  39. Locihova H, Axmann K, Padysakova H, Fejfar J. Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review. J Sleep Res. 2017. https://doi.org/10.1111/jsr.12607.

  40. Kamdar BB, Kamdar BB, Needham DM. Bundling sleep promotion with delirium prevention: ready for prime time? Anaesthesia. 2014;69(6):527–31.

    Article  CAS  PubMed  Google Scholar 

  41. • Marra A, Ely EW, Pandharipande PP, Patel MB. The ABCDEF bundle in critical care. Crit Care Clin. 2017;33(2):225–43. This recent paper describes a bundled approach to optimize ICU patient recovery and outcomes in multiple domains, including specific strategies for sleep promotion.

    Article  PubMed  Google Scholar 

  42. Gillis CM, Poyant JO, Degrado JR, Ye L, Anger KE, Owens RL. Inpatient pharmacological sleep aid utilization is common at a tertiary medical center. J Hosp Med. 2014;9(10):652–7.

    Article  PubMed  Google Scholar 

  43. U. S. Food and Drug Administration Center for Food Safety and Applied Nutrition. Kava-containing dietary supplements may be associated with severe liver injury. 2007; Available at: http://www.cfsan.fda.gov/~dms/addskava.html.

  44. Zee PC, Manthena P. The brain’s master circadian clock: implications and opportunities for therapy of sleep disorders. Sleep Med Rev. 2007;11(1):59–70.

  45. Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005;20(12):1151–8.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Zee PC, Attarian H, Videnovic A. Circadian rhythm abnormalities. Continuum (Minneap Minn). 2013;19(1 Sleep Disorders):132–47.

    Google Scholar 

  47. Schiffman J, Davis M, Pierre J, Saunders CS. Hydroxyzine: rational choice for inpatients with insomnia. Curr Psychiatr Ther. 2011;10(3):88.

    Google Scholar 

  48. Bertisch SM, Herzig SJ, Winkelman JW, Buettner C. National use of prescription medications for insomnia: NHANES 1999-2010. Sleep. 2014;37(2):343–9.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Mittur A. Trazodone: properties and utility in multiple disorders. Expert Rev Clin Pharmacol. 2011;4(2):181–96.

    Article  CAS  PubMed  Google Scholar 

  50. Kast RE. Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone. World J Biol Psychiatry. 2009;10(4 Pt 2):682–5.

    Article  PubMed  Google Scholar 

  51. Bateson AN. Further potential of the GABA receptor in the treatment of insomnia. Sleep Med. 2006;7:S3–9.

    Article  Google Scholar 

  52. Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48(2):301–10.

    Article  CAS  PubMed  Google Scholar 

  53. • Krystal AD, Richelson E, Roth T. Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013;17(4):263–72. Excellent discussion of the histamine system and the unique role of antihistamine medications on the sleep-wake cycle.

    Article  PubMed  Google Scholar 

  54. Winrow CJ, Gotter AL, Cox CD, Doran SM, Tannenbaum PL, Breslin MJ, et al. Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist. J Neurogenet. 2011;25(1–2):52–61.

    Article  CAS  PubMed  Google Scholar 

  55. Oto J, Yamamoto K, Koike S, Onodera M, Imanaka H, Nishimura M. Sleep quality of mechanically ventilated patients sedated with dexmedetomidine. Intensive Care Med. 2012;38(12):1982–9.

    Article  PubMed  Google Scholar 

  56. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, et al. Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care. 2010;14(2):R38.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, et al. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet. 2016;388(10054):1893–902.

    Article  CAS  PubMed  Google Scholar 

  58. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57–65.

    Article  PubMed  Google Scholar 

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Correspondence to David N. Neubauer.

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David N. Neubauer and Sapna Kudchadkar declare no conflicts of interest.

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This article is part of the Topical Collection on Insomnia and Pharmacotherapy

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Neubauer, D.N., Kudchadkar, S.R. Impatient for Inpatient Sleep: Treating Sleep Disturbances in the Hospital Setting. Curr Sleep Medicine Rep 3, 333–341 (2017). https://doi.org/10.1007/s40675-017-0098-8

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  • DOI: https://doi.org/10.1007/s40675-017-0098-8

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