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Use of allergy tests to identify dietary and environmental triggers of eosinophilic esophagitis: protocol for a systematic review

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Summary

Purpose

Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease. Most EoE patients have atopic comorbidities and they test positive when allergy tests are performed. Our aim is to critically assess the relation of allergens detected by allergy tests with clinically confirmed triggers of EoE.

Methods

A systemic review and meta-analysis will be conducted, which will involve searching electronic databases using predetermined search terms, in order to identify relevant studies. Studies will be independently screened against predefined eligibility criteria and subgroup analysis will be used for the outcomes.

Results and conclusion

The findings of this review are going to help clinicians and allied health professionals in treatment decisions.

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Author information

Authors and Affiliations

  1. Medical School, University of Cyprus, P.O. Box 20537, 1678, Nicosia, Cyprus

    Constantinos Pitsios, Katerina Pantavou, Maria Papachristodoulou, Georgios Panagiotis Tsigkrelis & Georgios K. Nikolopoulos

  2. ENT Department, Amsterdam University Medical Centre, Amsterdam, The Netherlands

    Ingrid Terreehorst

  3. Children’s Hospital of Philadelphia, University of Pennsylvania Medical School, Philadelphia, PA, USA

    Antonella Cianferoni

  4. Allergy and Immunology, Department of Pediatrics, Hassenfeld Children’s Hospital, New York University School of Medicine, New York, NY, USA

    Anna Nowak-Wegzryn

  5. Allergy Service, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain

    Carmen Vidal

  6. Department of Nutritional Sciences and Dietetics, International Hellenic University, Thessaloniki, Greece

    Emilia Vassilopoulou

  7. Department of Biomedical Sciences, Humanitas University, Milan, Italy

    Stefanos Bonovas

  8. Humanitas Clinical and Research Center-IRCCS, Milan, Italy

    Stefanos Bonovas

Authors
  1. Constantinos Pitsios
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  2. Katerina Pantavou
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  3. Ingrid Terreehorst
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  4. Antonella Cianferoni
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  5. Anna Nowak-Wegzryn
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  6. Carmen Vidal
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  7. Emilia Vassilopoulou
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  8. Maria Papachristodoulou
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  9. Georgios Panagiotis Tsigkrelis
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  10. Stefanos Bonovas
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  11. Georgios K. Nikolopoulos
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Corresponding author

Correspondence to Constantinos Pitsios.

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Conflict of interest

A. Nowak-Wegzryn reports grants from NIH NIAID, grants from DBV Technologies, grants from FARE, personal fees from Regeneron-Sanofi Aventis, personal fees from Gerber Nutrition Institute, grants from Nutricia, grants from Nestle, personal fees from UpToDate, personal fees from Ann All Asthma Immunol, outside the submitted work. C. Pitsios, K. Pantavou, I. Terreehorst, A. Cianferoni, C. Vidal, E. Vassilopoulou, M. Papachristodoulou, G. P. Tsigkrelis, S. Bonovas and G.K. Nikolopoulos declare that they have no competing interests.

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Pitsios, C., Pantavou, K., Terreehorst, I. et al. Use of allergy tests to identify dietary and environmental triggers of eosinophilic esophagitis: protocol for a systematic review. Allergo J Int 29, 280–283 (2020). https://doi.org/10.1007/s40629-020-00141-7

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  • DOI: https://doi.org/10.1007/s40629-020-00141-7

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