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Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche

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Abstract

Aim

We aimed to investigate serum nesfatin-1 level in girls with premature thelarche (PT) and its relationship with anthropometric parameters and leptin, which are involved in the initiation of pubertal process.

Subjects-methods

Non-obese girls who presented with the complaint of early (2–8 years) and isolated breast development were included in the study. The control group consisted of age-matched healthy prepubertal girls. Auxological measurements were performed in all subjects. Gonadotropin-releasing hormone (GnRH) stimulation test and bone age assessment were conducted in subjects with early breast development. Girls with a bone age/chronologic age ratio <1.2 and a peak luteinizing hormone (LH) response to GnRH stimulation <5 mIU/L were included in the PT group.

Results

The study included 22 non-obese girls with PT and 24 healthy prepubertal controls. Body mass index (BMI), BMI-standard deviation score (SDS) and height SDS were similar between the groups (p > 0.05). Serum leptin and nesfatin-1 levels were found significantly higher in the PT group compared to controls (p < 0.05). No correlation was detected between nesfatin-1 and basal LH, basal follicle stimulating hormone (FSH), stimulated peak LH, peak FSH, leptin levels and anthropometric parameters in the PT group (p > 0.05).

Conclusion

Results of the present study showed that serum nesfatin-1 and leptin levels are significantly higher in girls with PT than in prepubertal controls. This finding suggests that similar to leptin, nesfatin-1 may also have a central or peripheral role in the initiation of pubertal process and may be related to PT pathogenesis.

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References

  1. Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, Municchi G (1995) Progression of premature thelarche to central precocious puberty. J Pediatr 126(1):11–14

    Article  CAS  PubMed  Google Scholar 

  2. Ilicki A, Lewin PR, Kauli R, Kaufman H, Schachter A, Laron Z (1984) Premature thelarche–natural history and sex hormone secretion in 68 girls. Acta Paediatr Scand 73(6):756–762

    Article  CAS  PubMed  Google Scholar 

  3. Sizonenko PC (1978) Preadolescent and adolescent endocrinology: physiology and physiopathology. II. Hormonal changes during abnormal pubertal development. Am J Dis Child 132(8):797–805

    Article  CAS  PubMed  Google Scholar 

  4. Dumic M, Tajic M, Mardesic D, Kalafatic Z (1982) Premature thelarche: a possible adrenal disorder. Arch Dis Child 57(3):200–203

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. de Rodriguez SCA, Bongiovanni AM, de Borrego CL (1985) An epidemic of precocious development in Puerto Rican children. J Pediatr 107(3):393–396

    Article  Google Scholar 

  6. Buyukgebiz A, Bober E (2003) Premature thelarche caused by plant growth factors. J Pediatr Endocrinol Metab 16(2):237

    CAS  PubMed  Google Scholar 

  7. Pasquino AM, Piccolo F, Scalamandre A, Malvaso M, Ortolani R, Boscherini B (1980) Hypothalamic–pituitary–gonadotropic function in girls with premature thelarche. Arch Dis Child 55(12):941–944

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Beck W, Stubbe P (1984) Pulsatile secretion of luteinizing hormone and sleep-related gonadotropin rhythms in girls with premature thelarche. Eur J Pediatr 141(3):168–170

    Article  CAS  PubMed  Google Scholar 

  9. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2006) Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 254–255:127–132

    Article  PubMed  Google Scholar 

  10. Farooqi IS, O’Rahilly S (2014) 20 years of leptin: human disorders of leptin action. J Endocrinol 223(1):T63–T70

    Article  CAS  PubMed  Google Scholar 

  11. Oh IS, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K et al (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443(7112):709–712

    Article  Google Scholar 

  12. Garcia-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sanchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Gaytan F et al (2010) The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci 30(23):7783–7792

    Article  CAS  PubMed  Google Scholar 

  13. Garcia-Galiano D, Tena-Sempere M (2013) Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction. Curr Pharm Des 19(39):6966–6972

    Article  CAS  PubMed  Google Scholar 

  14. Berberoglu M (2009) Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol 1(4):164–174

    PubMed Central  PubMed  Google Scholar 

  15. Neely EK, Hintz RL, Wilson DM, Lee PA, Gautier T, Argente J, Stene M (1995) Normal ranges for immunochemiluminometric gonadotropin assays. J Pediatr 127(1):40–46

    Article  CAS  PubMed  Google Scholar 

  16. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, Mei Z, Curtin LR, Roche AF, Johnson CL (2000) CDC growth charts: United States. Adv Data 314:1–27

    PubMed  Google Scholar 

  17. Rosner B, Prineas R, Loggie J, Daniels SR (1998) Percentiles for body mass index in U.S. children 5 to 17 years of age. J Pediatr 132(2):211–222

    Article  CAS  PubMed  Google Scholar 

  18. Marshall WA, Tanner JM (1969) Variations in pattern of pubertal changes in girls. Arch Dis Child 44(235):291–303

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist, 2nd edn. Stanford University Press, California

  20. de Vries L, Horev G, Schwartz M, Phillip M (2006) Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche. Eur J Endocrinol 154(6):891–898

    Article  PubMed  Google Scholar 

  21. Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA (1997) Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 138(2):855–858

    Article  CAS  PubMed  Google Scholar 

  22. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O’Rahilly S (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341(12):879–884

    Article  CAS  PubMed  Google Scholar 

  23. Abaci A, Catli G, Anik A, Kume T, Bober E (2013) The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children. Pediatr Diabetes 14(3):189–195

    CAS  PubMed  Google Scholar 

  24. Verrotti A, Basciani F, Trotta D, De Simone M, Morgese G, Chiarelli F (2003) Serum leptin levels in girls with precocious puberty. Diabetes Nutr Metab 16(2):125–129

    CAS  PubMed  Google Scholar 

  25. Palmert MR, Radovick S, Boepple PA (1998) Leptin levels in children with central precocious puberty. J Clin Endocrinol Metab 83(7):2260–2265

    CAS  PubMed  Google Scholar 

  26. Dundar B, Pirgon O, Sangun O, Doguc DK (2013) Elevated leptin levels in nonobese girls with premature thelarche. J Investig Med 61(6):984–988

    CAS  PubMed  Google Scholar 

  27. Erhardt E, Foraita R, Pigeot I, Barba G, Veidebaum T, Tornaritis M, Michels N, Eiben G, Ahrens W, Moreno LA et al (2014) Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort. Int J Obes (Lond) 38(Suppl 2):S32–S38

    Article  Google Scholar 

  28. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, Patel S, Kern W, Hillhouse EW, Lehnert H, Tan BK et al (2010) Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 151(7):3169–3180

    Article  CAS  PubMed  Google Scholar 

  29. Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Tache Y, Sachs G, Lambrecht NW (2009) Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 150(1):232–238

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Lents CA, Barb CR, Hausman GJ, Nonneman D, Heidorn NL, Cisse RS, Azain MJ (2013) Effects of nesfatin-1 on food intake and LH secretion in prepubertal gilts and genomic association of the porcine NUCB2 gene with growth traits. Domest Anim Endocrinol 45(2):89–97

    Article  CAS  PubMed  Google Scholar 

  31. Garcia-Galiano D, Pineda R, Ilhan T, Castellano JM, Ruiz-Pino F, Sanchez-Garrido MA, Vazquez MJ, Sangiao-Alvarellos S, Romero-Ruiz A, Pinilla L et al (2012) Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology 153(4):1959–1971

    Article  CAS  PubMed  Google Scholar 

  32. Price TO, Samson WK, Niehoff ML, Banks WA (2007) Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Peptides 28(12):2372–2381

    Article  CAS  PubMed  Google Scholar 

  33. Pan W, Hsuchou H, Kastin AJ (2007) Nesfatin-1 crosses the blood-brain barrier without saturation. Peptides 28(11):2223–2228

    Article  CAS  PubMed  Google Scholar 

  34. Heger S, Partsch CJ, Peter M, Blum WF, Kiess W, Sippell WG (1999) Serum leptin levels in patients with progressive central precocious puberty. Pediatr Res 46(1):71–75

    Article  CAS  PubMed  Google Scholar 

  35. Anwar GM, Yamamah G, Ibrahim A, El-Lebedy D, Farid TM, Mahmoud R (2014) Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance. Regul Pept 188:21–24

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Conflict of interest

We declare that we do not have any conflicts of interest and no financial relationships that might have influenced the present work.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Pediatric Endocrinology Unit, Tepecik Training and Research Hospital, Izmir, Turkey

    G. Çatlı

  2. Department of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey

    A. Anık, E. Böber & A. Abacı

  3. Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

    T. Küme & Ö. G. Çalan

  4. Department of Pediatric Endocrinology, Faculty of Medicine, Katip Çelebi University, Izmir, Turkey

    B. N. Dündar

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  1. G. Çatlı
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  2. A. Anık
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  3. T. Küme
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  4. Ö. G. Çalan
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  5. B. N. Dündar
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  6. E. Böber
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  7. A. Abacı
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Correspondence to A. Abacı.

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Çatlı, G., Anık, A., Küme, T. et al. Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche. J Endocrinol Invest 38, 909–913 (2015). https://doi.org/10.1007/s40618-015-0277-8

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  • DOI: https://doi.org/10.1007/s40618-015-0277-8

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