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Recurrent Fetal Hydrops: Importance of Genetic Testing with Exome Sequencing—A Case Report

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Journal of Fetal Medicine

Abstract

We report the case of a pregnant lady who had hydrops fetalis in three successive pregnancies and discuss the possible genetic causes and the systematic approach to evaluation of her pregnancy and her future reproductive options. Hydrops fetalis can occur due to a heterogeneous number of causes. Systematic evaluation helps in determining the cause which then determines the prognosis as well as recurrence in future pregnancies. Recurrent hydrops though rare, can occur because of single gene defects causing hematological, neurological, cardiac conditions, etc. Genetic testing and consideration of the role of exome sequencing is important in counseling families regarding their future pregnancy options as well as to offer prenatal diagnosis.

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References

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Acknowledgements

We thank the patient for her consent to publish the case.

Funding

No external funding received.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Rangadore Memorial Hospital, First cross road, Shankarapuram, Bangalore, Karnataka, 560004, India

    Srimathy Raman, Prakruthi K. Prakash, Savitha Shirodkar, Shreelakshmi Gururaj & Padmalatha Venkataram

Authors
  1. Srimathy Raman
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  2. Prakruthi K. Prakash
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  3. Savitha Shirodkar
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  4. Shreelakshmi Gururaj
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  5. Padmalatha Venkataram
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Contributions

The first author was responsible for the initial draft of the manuscript. The others supervised the drafting and editing of the manuscript and read and approved the final manuscript. The authors affirm that it is an honest, accurate and transparent report of the patient being reported and take full responsibility for the article, including the accuracy and appropriateness of the reference list.

Corresponding author

Correspondence to Srimathy Raman.

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Conflict of interest

The case report has been published as a poster in CUSP conference, Chennai-Sep 2018. The authors declare that there is no other conflict of interest.

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This is a case report and hence the Research Ethics Committee has confirmed that no ethical approval is required.

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Raman, S., Prakash, P.K., Shirodkar, S. et al. Recurrent Fetal Hydrops: Importance of Genetic Testing with Exome Sequencing—A Case Report. J. Fetal Med. 8, 217–220 (2021). https://doi.org/10.1007/s40556-021-00318-2

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  • DOI: https://doi.org/10.1007/s40556-021-00318-2

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