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Prenatal Binder Phenotype: Physician’s Dilemma-A Case Report

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Journal of Fetal Medicine

Abstract

The Binder phenotype is defined by midface hypoplasia, underdeveloped frontal sinuses, hypoplastic and abnormally positioned nasal bones, nostrils appearing moon or comma-shaped and prognathism. It is heterogeneous in etiology and not fully understood. Multiple causative factors are described. The physician’s dilemma is of diagnosing the fetal abnormalities on antenatal ultrasound for which there is no confirmatory testing. There are management and ethical problems regarding the diagnosis, further investigations and confirmation of the diagnosis. The Binder phenotype is a clinical diagnosis with multiple differential diagnoses. It carries an uncertain and unpredictable course and prognosis which might be difficult for both clinician and parents to predict and comprehend. Genetic counseling has to be variable depending upon the diagnosis.

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Authors and Affiliations

  1. Foetal Medicine and Medical Genetics, Artemis Hospitals, Sector 51, Gurgaon, 122001, India

    Ashutosh Gupta

  2. Department of Minimal Access Surgery (Gynecology), Fortis Memorial Research Institute, Gurgaon, Sector 44, Gurgaon, 122001, India

    Anjila Aneja & Neena Bahl

  3. Department of Obstetrics and Gynecology, Max Balaji Hospital, 108 A, Indraprastha extension, Patparganj, New Delhi, 110092, India

    Rupam Arora

  4. Department of Obstetrics and Gynecology, Artemis Health Institute, Sector 51, Gurgaon, 122001, India

    Renu Raina Sehgal

  5. Department of Radiology, Manipal Hospitals, Sector 6, Dwarka, New Delhi, 110075, India

    Pankaj Saini

Authors
  1. Ashutosh Gupta
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  2. Anjila Aneja
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  3. Neena Bahl
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  4. Rupam Arora
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  5. Renu Raina Sehgal
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  6. Pankaj Saini
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Correspondence to Ashutosh Gupta.

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Gupta, A., Aneja, A., Bahl, N. et al. Prenatal Binder Phenotype: Physician’s Dilemma-A Case Report. J. Fetal Med. 8, 65–70 (2021). https://doi.org/10.1007/s40556-020-00283-2

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  • DOI: https://doi.org/10.1007/s40556-020-00283-2

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