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Current Standards and Improvements in the Use of SLIT Tablets for Allergen Immunotherapy

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The clinical use of sublingual allergen immunotherapy (SLIT) can be traced back several decades. Ever since that first use, scientists have sought to develop new ways of application for immunotherapy. SLIT with aqueous formulations was mainly used but has a number of practical limitations, such as the need for refrigeration, poor dosing accuracy, and allergen spreading from the sublingual zone to other enoral and pharyngeal regions. Solid pharmaceutical formulations of allergen extracts in the form of freeze-dried sublingual tablets have been first clinically studied in the 1990s and were followed by DBPC prospective studies from 2006 onwards. Today, there are numerous different products of fast dissolving SLIT tablets for several allergens. Their clinical use and scientific background and evidence are discussed.

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Abbreviations

AIT:

Allergen immunotherapy

SLIT:

Sublingual immunotherapy

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Authors and Affiliations

  1. Center for Rhinology and Allergology, Wiesbaden, Germany

    L. Klimek MD, P. Demoly MD, PhD & O. Pfaar MD

  2. Department of Respiratory Medicine and Addiction Medicine, Arnaud de Villeneuve Hospital, Montpellier University Hospital, Paris, France

    P. Demoly MD, PhD

  3. Sorbonne Universities, Paris, France

    P. Demoly MD, PhD

  4. Vienna Challenge Chamber, Allergy Center Vienna West, Vienna, Austria

    P. Zieglmayer MD

  5. Department of Dermatology, Venereology, and Allergology Charité University Hospital, Charité Mitte Campus, Charitéplatz 1, 10117, Berlin, Germany

    M. Worm MD

  6. Allergy and Respiratory Diseases, Department of Internal Medicine, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy

    G. Passalacqua MD

  7. Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    O. Pfaar MD

Authors
  1. L. Klimek MD
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  2. P. Demoly MD, PhD
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  3. P. Zieglmayer MD
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  4. M. Worm MD
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  5. G. Passalacqua MD
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  6. O. Pfaar MD
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Corresponding author

Correspondence to L. Klimek MD.

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Klimek, L., Demoly, P., Zieglmayer, P. et al. Current Standards and Improvements in the Use of SLIT Tablets for Allergen Immunotherapy. Curr Treat Options Allergy 4, 286–289 (2017). https://doi.org/10.1007/s40521-017-0133-5

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  • DOI: https://doi.org/10.1007/s40521-017-0133-5

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