Abstract
Purpose
Some features of eating disorders (EDs) are often present in childhood before the onset of the ED. We developed a novel questionnaire to retrospectively capture such childhood traits.
Methods
Focus groups were conducted at the University of California–San Diego, USA, and at the University of Turin, Italy. Three focus groups were conducted at each site, interviewing patients and parents to identify those traits that most commonly characterize childhood of patients with EDs. A preliminary version of the Premorbid Childhood Traits Questionnaire (PCT-Q) derived from these focus groups was then administered to 94 consecutive inpatients with an ED and to 286 healthy controls (HCs) at the Turin site. Also, 208 participants’ parents were enrolled as well; in fact, the PCT-Q was developed with both a proband and an informant version.
Results
A 37-item final version of the PCT-Q was generated. Reliability analyses suggested acceptability for harm avoidance (HA), social phobia, alexithymia, interoceptive awareness (IA), and food obsessions. Inter-rater reliability ranged from fair to moderate. ED sufferers scored significantly higher than HCs on HA, social phobia, alexithymia, IA, and food obsessions.
Conclusions
These findings support the possibility that premorbid traits contribute to a risk to develop an ED in some individuals.
Level of evidence
III: case–control analytic study.
Similar content being viewed by others
Data availability
The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Klump KL, Strober M, Bulik CM, Thornton L, Johnson C, Devlin B et al (2004) Personality characteristics of women before and after recovery from an eating disorder. Psychol Med 34(8):1407–1418
Carrot B, Radon L, Hubert T, Vibert S, Duclos J, Curt F, Godart N (2017) Are lifetime affective disorders predictive of long-term outcome in severe adolescent anorexia nervosa? Eur Child Adolesc Psychiatry 26:969–978. https://doi.org/10.1007/s00787-017-0963-5
Anderluh MB, Tchanturia K, Rabe-Hesketh S, Treasure J (2003) Childhood obsessive-compulsive personality traits in adult women with eating disorders: defining a broader eating disorder phenotype. Am J Psychiatry 160(2):242–247. https://doi.org/10.1176/appi.ajp.160.2.242
Jacobi C, Hayward C, de Zwaan M, Kraemer HC, Agras WS (2004) Coming to terms with risk factors for eating disorders: application of risk terminology and suggestions for a general taxonomy. Psychol Bull 130(1):19–65. https://doi.org/10.1037/0033-2909.130.1.19
Himmerich H, Bentley J, Kan C, Treasure J (2019) Genetic risk factors for eating disorders: an update and insights into pathophysiology. Ther Adv Psychopharmacol 9:2045125318814734. https://doi.org/10.1177/2045125318814734
Marzola E, Fassino S, Amianto F, Abbate-Daga G (2017) Affective temperaments in anorexia nervosa: the relevance of depressive and anxious traits. J Affect Disord 218:23–29. https://doi.org/10.1016/j.jad.2017.04.054
Fassino S, Abbate-Daga G, Amianto F, Leombruni P, Boggio S, Rovera GG (2002) Temperament and character profile of eating disorders: a controlled study with the Temperament and Character Inventory. Int J Eat Disord 32(4):412–425. https://doi.org/10.1002/eat.10099
Lilenfeld LR (2011) Personality and temperament. Curr Top Behav Neurosci 6:3–16. https://doi.org/10.1007/7854_2010_86
Thornton LM, Trace SE, Brownley KA, Ålgars M, Mazzeo SE, Bergin JE, Maxwell M, Lichtenstein P, Pedersen NL, Bulik CM (2017) A comparison of personality, life events, comorbidity, and health in monozygotic twins discordant for anorexia nervosa. Twin Res Hum Genet 20:310–318. https://doi.org/10.1017/thg.2017.27
Stanfield AC, McKechanie AG, Lawrie SM, Johnstone EC (2019) Owens D.G.C.: predictors of psychotic symptoms among young people with special educational needs. Br J Psychiatry 5:1–6. https://doi.org/10.1192/bjp.2018.296
Culbert KM, Racine SE, Klump KL (2015) Research review: what we have learned about the causes of eating disorders—a synthesis of sociocultural, psychological, and biological research. J Child Psychol Psychiatry 56(11):1141–1164. https://doi.org/10.1111/jcpp.12441
Boone L, Soenens B, Luyten P (2014) When or why does perfectionism translate into eating disorder pathology? A longitudinal examination of the moderating and mediating role of body dissatisfaction. J Abnorm Psychol 123(2):412–418. https://doi.org/10.1037/a0036254
Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50(12):975–990
Atiye M, Miettunen J, Raevuori-Helkamaa A (2015) A meta-analysis of temperament in eating disorders. Eur Eat Disord Rev 23:89–99. https://doi.org/10.1002/erv.2342
Lilenfeld L, Wonderlich S, Riso L, Crosby R, Mitchell J (2006) Eating disorders and personality: a methodological and empirical review. Clin Psychol Rev 26(3):299–320
Duffy ME, Rogers ML, Joiner TE, Bergen AW, Berrettini W, Bulik CM, Brandt H, Crawford S, Crow S, Fichter M, Halmi K, Kaplan AS, Klump KL, Lilenfeld L, Magistretti PJ, Mitchell J, Schork NJ, Strober M, Thornton LM, Treasure J, Woodside B, Kaye WH, Keel PK (2019) An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses. Int J Eat Disord 52:200–205. https://doi.org/10.1002/eat.23008
Harrison A, O’Brien N, Lopez C, Treasure J (2010) Sensitivity to reward and punishment in eating disorders. Psychiatry Res 177(1–2):1–11. https://doi.org/10.1016/j.psychres.2009.06.010
Jappe LM, Frank GK, Shott ME, Rollin MD, Pryor T, Hagman JO et al (2011) Heightened sensitivity to reward and punishment in anorexia nervosa. Int J Eat Disord 44(4):317–324. https://doi.org/10.1002/eat.20815
Bischoff-Grethe A, McCurdy D, Grenesko-Stevens E, Irvine LE, Wagner A, Yau WY, Fennema-Notestine C, Wierenga CE, Fudge JL, Delgado MR, Kaye WH (2013) Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Res 214:331–340. https://doi.org/10.1016/j.pscychresns.2013.07.004
Fassino S, Pierò A, Gramaglia C, Abbate-Daga G (2004) Clinical, psychopathological and personality correlates of interoceptive awareness in anorexia nervosa, bulimia nervosa and obesity. Psychopathology 37(4):168–174. https://doi.org/10.1159/000079420
Wierenga CE, Ely A, Bischoff-Grethe A, Bailer UF, Simmons AN, Kaye WH (2014) Are extremes of consumption in eating disorders related to an altered balance between reward and inhibition? Front Behav Neurosci 8:410. https://doi.org/10.3389/fnbeh.2014.00410
Bailer UF, Price JC, Meltzer CC, Wagner A, Mathis CA, Gamst A et al (2017) Dopaminergic activity and altered reward modulation in anorexia nervosa-insight from multimodal imaging. Int J Eat Disord 50(5):593–596. https://doi.org/10.1002/eat.22638
Asaad Abdou T, Esawy HI, Abdel Razek Mohamed G, Hussein Ahmed H, Elhabiby MM, Khalil SA, El-Hawary YA (2018) Sleep profile in anorexia and bulimia nervosa female patients. Sleep Med 48:113–116. https://doi.org/10.1016/j.sleep.2018.03.032
Smink FR, van Hoeken D, Hoek HW (2012) Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep 14(4):406–414. https://doi.org/10.1007/s11920-012-0282-y
Southgate L, Tchanturia K, Collier D, Treasure J (2008) The development of the childhood retrospective perfectionism questionnaire (CHIRP) in an eating disorder sample. Eur Eat Disord Rev 16(6):451–462. https://doi.org/10.1002/erv.870
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5, 5th edn. American Psychiatric Association, Arlington
First MB, Williams JB, Karg RS, Spitzer RL (2015) SCID-5-CV: structured clinical interview for DSM-5 disorders; clinician version. American Psychiatric Association Publishing, Arlington
Frost RO, Marten P, Lahart C, Rosenblate R (1990) The dimensions of perfectionism. Cogn Ther Res 14:449
Garner DM (1991) Eating Disorder Inventory-2. Professional manual. Psychological Assessment Resources Inc, Odessa
Thiel A, Paul T (2006) Test–retest reliability of the Eating Disorder Inventory 2. J Psychosom Res 61(4):567–569
Nunnally JC, Bernstein IH (1994) Psychometric theory, 3rd edn. Mc Graw Hill, New York
Cho E, Kim S (2015) Cronbach’s coefficient alpha: well known but poorly understood. Organ Res Methods 8(2):207–230
Cortina JM (1993) What is coefficient alpha? An examination of theory and applications. J Appl Psychol 78(1):98–104
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174
Kaye WH, Bulik CM, Thornton L, Barbarich N, Masters K (2004) Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am J Psychiatry 161(12):2215–2221. https://doi.org/10.1176/appi.ajp.161.12.2215
Abbate-Daga G, Quaranta M, Marzola E, Amianto F, Fassino S (2015) The relationship between alexithymia and intolerance of uncertainty in anorexia nervosa. Psychopathology 48(3):202–208. https://doi.org/10.1159/000381587
Kaye WH, Fudge JL, Paulus M (2009) New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 10(8):573–584. https://doi.org/10.1038/nrn2682
Bailer UF, Frank GK, Price JC, Meltzer CC, Becker C, Mathis CA et al (2013) Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa. Psychiatry Res 211(2):160–168. https://doi.org/10.1016/j.pscychresns.2012.06.010
Swinbourne J, Hunt C, Abbott M, Russell J, St Clare T, Touyz S (2012) The comorbidity between eating disorders and anxiety disorders: prevalence in an eating disorder sample and anxiety disorder sample. Aust N Z J Psychiatry 46(2):118–131. https://doi.org/10.1177/0004867411432071
Deep AL, Nagy LM, Weltzin TE, Rao R, Kaye WH (1995) Premorbid onset of psychopathology in long-term recovered anorexia nervosa. Int J Eat Disord 17(3):291–297
Salbach-Andrae H, Lenz K, Simmendinger N, Klinkowski N, Lehmkuhl U, Pfeiffer E (2008) Psychiatric comorbidities among female adolescents with anorexia nervosa. Child Psychiatry Hum Dev 39(3):261–272. https://doi.org/10.1007/s10578-007-0086-1
Pollice C, Kaye WH, Greeno CG, Weltzin TE (1997) Relationship of depression, anxiety, and obsessionality to state of illness in anorexia nervosa. Int J Eat Disord 21(4):367–376
Wade TD, Bulik CM, Neale M, Kendler KS (2000) Anorexia nervosa and major depression: shared genetic and environmental risk factors. Am J Psychiatry 157(3):469–471. https://doi.org/10.1176/appi.ajp.157.3.469
Steinglass J, Albano AM, Simpson HB, Carpenter K, Schebendach J, Attia E (2012) Fear of food as a treatment target: exposure and response prevention for anorexia nervosa in an open series. Int J Eat Disord 45(4):615–621. https://doi.org/10.1002/eat.20936
Waller G, Shaw T, Meyer C, Haslam M, Lawson R, Serpell L (2012) Persistence, perseveration and perfectionism in the eating disorders. Behav Cogn Psychother 40(4):462–473. https://doi.org/10.1017/S135246581200015X
Frank GK, Roblek T, Shott ME, Jappe LM, Rollin MD, Hagman JO et al (2012) Heightened fear of uncertainty in anorexia and bulimia nervosa. Int J Eat Disord 45(2):227–232. https://doi.org/10.1002/eat.20929
Hasler BP, Kirisci L, Clark DB (2016) Restless sleep and variable sleep timing during late childhood accelerate the onset of alcohol and other drug involvement. J Stud Alcohol Drugs 77(4):649–655
Jacoby A, Snape D, Lane S, Baker GA (2015) Self-reported anxiety and sleep problems in people with epilepsy and their association with quality of life. Epilepsy Behav 43:149–158. https://doi.org/10.1016/j.yebeh.2014.09.071
Funding
This is unfunded research.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of topical collection on Personality and eating and weight disorders.
The study took place at two sites: at the University of California San Diego, Eating Disorders Research and Treatment Program, Chancellor Park, 4510 Executive Drive, Suite 315, San Diego CA 92121; and at the Eating Disorders Centre of the University of Turin, via Cherasco 11, 10126, Turin, Italy.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Marzola, E., Fassino, S., Migliaretti, G. et al. Development and validation of the Premorbid Childhood Traits Questionnaire (PCT-Q) in eating disorders. Eat Weight Disord 24, 815–823 (2019). https://doi.org/10.1007/s40519-019-00748-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40519-019-00748-y