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Epigenetics, Inflammation, and Periodontal Disease

  • Systemic Diseases (N Buduneli, Section Editor)
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Current Oral Health Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

The purpose is to provide current knowledge and recent development and understanding of periodontal disease dysbiosis in the perspective of epigenetic changes. Epigenetic changes, where environmental factors modify the gene expression network without changing the DNA sequence, may influence inflammatory diseases such as chronic periodontitis. These chemical modifications of DNA and histone proteins cause epigenetic changes that alter cellular function and host defenses.

Recent Findings

Findings suggest that the methylation of cytosine residues on DNA particularly at CpG Islands is commonly associated with gene silencing, and covalent modifications on histones are associated with chromatin structural integrity and function that play crucial roles in gene expression. In periodontal immune dysbiosis, aberrant DNA methylation and/or histone modifications could potentially play a role in disease state.

Summary

We broadly discuss epigenetic modifications related to immune regulation and comprehensively discuss recent developments in the dynamics of epigenetic changes pertaining to chronic inflammatory periodontal disease.

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Funding

This work was partially supported by United States Public Health Service, National Institutes of Health, NIDCR grant DE017384 and by the internal funding of the University of Pennsylvania to DFK and MRB.

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Author notes

  1. Daniela B. Palioto

    Present address: Department of OMS and Periodontology, University of São Paulo - School of Dentistry of Ribeirão, Preto, Brazil

Authors and Affiliations

  1. Department of Periodontics, School of Dental Medicine, University of Pennsylvania, 240 South 40th street, Philadelphia, PA, 19104, USA

    Manjunatha R. Benakanakere, Livia Finoti & Daniela B. Palioto

  2. Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19004, USA

    Hellen S. Teixeira

  3. Division of Periodontology, School of Dental Medicine, University of Geneva Faculty of Medicine, Geneva, Switzerland

    Denis F. Kinane

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  1. Manjunatha R. Benakanakere
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  2. Livia Finoti
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Correspondence to Manjunatha R. Benakanakere.

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Benakanakere, M.R., Finoti, L., Palioto, D.B. et al. Epigenetics, Inflammation, and Periodontal Disease. Curr Oral Health Rep 6, 37–46 (2019). https://doi.org/10.1007/s40496-019-0208-4

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