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Allografts and Xenografts for Periodontal Plastic Surgical Procedures

  • Clinical Periodontics (Y Stathopoulou, Section Editor)
  • Published:
Current Oral Health Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The selection of surgical techniques and grafting materials is undoubtedly a critical component in the treatment of gingival recession defects. In order to provide top quality care, dental professionals are always in pursuit of treatment modality that provides maximal efficacy and predictability with minimal patient morbidity. The subepithelial connective tissue graft procedure, the gold standard, has been consistently proven to show excellent root coverage, but limited palatal tissue availability and potential morbidity associated with the harvesting process push dental practitioners to seek an alternative. The same holds true for peri-implant tissues—while autogenous grafts have served our purpose well, alternatives that can achieve similar results while avoiding a second intraoral wound (the donor sites) are preferred. The purpose of this review of recent studies is to evaluate the effectiveness and predictability of allografts and xenografts for root coverage procedures and around dental implants.

Recent Findings

The electronic database search was limited to the past 5 years and to the studies addressing root coverage procedures in the Miller class I and II gingival recession (even though the 2017 International Workshop suggested a new classification, the majority of research projects use the classic Miller classification). Search was also made for studies addressing soft tissue treatment around implants that were published during the same period. A total of 30 human clinical trials involving allografts (mainly acellular dermal matrix and placental membranes) and xenografts (porcine-derived collagen matrix) for treatment of gingival recession and a total of 19 clinical studies using allografts and xenografts to improve soft tissue quality around implants were selected.

Summary

Based on the selected studies, acellular dermal matrix in combination with various flap designs appears to produce results similar to autogenous grafts in terms of mean root coverage and width of keratinized tissue. Other grafting materials, while less effective compared to autogenous grafts, still show some promise especially in patient-centered outcomes. For soft tissue quality improvement around implant sites, allografts and xenografts in general provide satisfactory clinical results. Multicenter, randomized clinical studies with large numbers of individuals and long-term outcomes may provide the most realistic answer for this topic.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Cortellini P, Bissada NF. Mucogingival conditions in the natural dentition: narrative review, case definitions, and diagnostic considerations. J Periodontol. 2018;89(Suppl 1):S204–S13. https://doi.org/10.1002/JPER.16-0671.

    Article  PubMed  Google Scholar 

  2. Albandar JM, Kingman A. Gingival recession, gingival bleeding, and dental calculus in adults 30 years of age and older in the United States, 1988-1994. J Periodontol. 1999;70(1):30–43. https://doi.org/10.1902/jop.1999.70.1.30.

    Article  CAS  PubMed  Google Scholar 

  3. Chambrone L, Tatakis DN. Long-term outcomes of untreated buccal gingival recessions: a systematic review and meta-analysis. J Periodontol. 2016;87(7):796–808. https://doi.org/10.1902/jop.2016.150625.

    Article  PubMed  Google Scholar 

  4. • Mounssif I, Stefanini M, Mazzotti C, Marzadori M, Sangiorgi M, Zucchelli G. Esthetic evaluation and patient-centered outcomes in root-coverage procedures. Periodontol 2000. 2018;77(1):19–53. https://doi.org/10.1111/prd.12216 This article reviews root coverage procedures with special focus on esthetics and patient-centered outcomes.

    Article  PubMed  Google Scholar 

  5. Zuhr O, Baumer D, Hurzeler M. The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution. J Clin Periodontol. 2014;41(Suppl 15):S123–42. https://doi.org/10.1111/jcpe.12185.

    Article  PubMed  Google Scholar 

  6. Wei PC, Laurell L, Geivelis M, Lingen MW, Maddalozzo D. Acellular dermal matrix allografts to achieve increased attached gingiva. Part 1. A clinical study. J Periodontol. 2000;71(8):1297–305. https://doi.org/10.1902/jop.2000.71.8.1297.

    Article  CAS  PubMed  Google Scholar 

  7. Bassetti RG, Stahli A, Bassetti MA, Sculean A. Soft tissue augmentation around osseointegrated and uncovered dental implants: a systematic review. Clin Oral Investig. 2017;21(1):53–70. https://doi.org/10.1007/s00784-016-2007-9.

    Article  PubMed  Google Scholar 

  8. Ahmedbeyli C, Ipci SD, Cakar G, Yilmaz S. Laterally positioned flap along with acellular dermal matrix graft in the management of maxillary localized recessions. Clin Oral Investig. 2019;23(2):595–601. https://doi.org/10.1007/s00784-018-2475-1.

    Article  PubMed  Google Scholar 

  9. Ahmedbeyli C, Ipci SD, Cakar G, Kuru BE, Yilmaz S. Clinical evaluation of coronally advanced flap with or without acellular dermal matrix graft on complete defect coverage for the treatment of multiple gingival recessions with thin tissue biotype. J Clin Periodontol. 2014;41(3):303–10. https://doi.org/10.1111/jcpe.12211.

    Article  PubMed  Google Scholar 

  10. Thakare P, Baliga V, Bhongade ML. Comparative evaluation of the effectiveness of acellular dermal matrix allograft and subepithelial connective tissue to coronally advanced flap alone in the treatment of multiple gingival recessions: a clinical study. J Indian Soc Periodontol. 2015;19(5):537–44. https://doi.org/10.4103/0972-124X.156877.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Goyal N, Gupta R, Pandit N, Dahiya P. Analysis of patient acceptance following treatment of Miller’s class II gingival recession with acellular dermal matrix and connective tissue graft. J Indian Soc Periodontol. 2014;18(3):352–6. https://doi.org/10.4103/0972-124X.134574.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Barros RR, Macedo GO, de Queiroz AC, Novaes AB Jr. A modified surgical flap for root coverage in association with grafting materials. J Esthet Restor Dent. 2015;27(2):84–91. https://doi.org/10.1111/jerd.12122.

    Article  PubMed  Google Scholar 

  13. Godavarthi L, Murthy KR, Pavankumar S. A comparison of acellular dermal matrix allograft and periosteal pedicle graft covered by coronally advanced flap in the treatment of gingival recession: 1-year follow-up study. Int J Periodontics Restorative Dent. 2016;36(4):e67–75. https://doi.org/10.11607/prd.2461.

    Article  PubMed  Google Scholar 

  14. Ozenci I, Ipci SD, Cakar G, Yilmaz S. Tunnel technique versus coronally advanced flap with acellular dermal matrix graft in the treatment of multiple gingival recessions. J Clin Periodontol. 2015;42(12):1135–42. https://doi.org/10.1111/jcpe.12477.

    Article  CAS  PubMed  Google Scholar 

  15. Ayub LG, Ramos UD, Reino DM, Grisi MF, Taba M Jr, Souza SL, et al. A modified surgical technique for root coverage with an allograft: a 12-month randomized clinical trial. J Periodontol. 2014;85(11):1529–36. https://doi.org/10.1902/jop.2014.140111.

    Article  PubMed  Google Scholar 

  16. Wang HL, Romanos GE, Geurs NC, Sullivan A, Suarez-Lopez Del Amo F, Eber RM. Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized multicenter study. J Periodontol. 2014;85(12):1693–701. https://doi.org/10.1902/jop.2014.140198.

    Article  PubMed  Google Scholar 

  17. Abou-Arraj RV, Kaur M, Vassilopoulos PJ, Geurs NC. Creation of a zone of immobile connective tissue with acellular dermal matrix allografts. Int J Periodontics Restorative Dent. 2017;37(4):571–9. https://doi.org/10.11607/prd.2952.

    Article  PubMed  Google Scholar 

  18. Costa PP, Alves LB, Souza SL, Grisi MF, Palioto DB, Taba M Jr, et al. Root coverage in smokers with acellular dermal matrix graft and enamel matrix derivative: a 12-month randomized clinical trial. Int J Periodontics Restorative Dent. 2016;36(4):525–31. https://doi.org/10.11607/prd.2560.

    Article  PubMed  Google Scholar 

  19. Chaparro A, De la Fuente M, Albers D, Hernandez D, Villalobos AM, Gaedechens D, et al. Root coverage of multiple Miller class I and II recession defects using acellular dermal matrix and tunneling technique in maxilla and mandible: a 1-year report. Int J Periodontics Restorative Dent. 2015;35(5):639–45. https://doi.org/10.11607/prd.1998.

    Article  PubMed  Google Scholar 

  20. Romanos AH, Abou-Arraj RV, Cruz SE, Majzoub ZA. Clinical and patient-centered outcomes following treatment of multiple gingival recessions using acellular dermal matrix allografts. Int J Periodontics Restorative Dent. 2017;37(6):843–51. https://doi.org/10.11607/prd.3335.

    Article  PubMed  Google Scholar 

  21. Mahn DH. A double-layer technique using an acellular dermal matrix for the treatment of Miller class I and II gingival recession defects: 1-year results of 50 consecutive cases. Int J Periodontics Restorative Dent. 2015;35(2):257–62. https://doi.org/10.11607/prd.2001.

    Article  PubMed  Google Scholar 

  22. Bednarz W, Zurek J, Gedrange T, Dominiak M. A preliminary clinical comparison of the use of fascia lata allograft and autogenous connective tissue graft in multiple gingival recession coverage based on the tunnel technique. Adv Clin Exp Med. 2016;25(3):587–98. https://doi.org/10.17219/acem/44849.

    Article  PubMed  Google Scholar 

  23. George SG, Kanakamedala AK, Mahendra J, Kareem N, Mahendra L, Jerry JJ. Treatment of gingival recession using a coronally-advanced flap procedure with or without placental membrane. J Investig Clin Dent. 2018;9(3):e12340. https://doi.org/10.1111/jicd.12340.

    Article  PubMed  Google Scholar 

  24. Agarwal SK, Jhingran R, Bains VK, Srivastava R, Madan R, Rizvi I. Patient-centered evaluation of microsurgical management of gingival recession using coronally advanced flap with platelet-rich fibrin or amnion membrane: a comparative analysis. Eur J Dent. 2016;10(1):121–33. https://doi.org/10.4103/1305-7456.175686.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Mahajan R, Khinda P, Shewale A, Ghotra K, Bhasin MT, Bhasin P. Comparative efficacy of placental membrane and Healiguide in treatment of gingival recession using guided tissue regeneration. J Indian Soc Periodontol. 2018;22(6):513–22. https://doi.org/10.4103/jisp.jisp_88_18.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Jain A, Jaiswal GR, Kumathalli K, Kumar R, Singh A, Sarwan A. Comparative evaluation of platelet rich fibrin and dehydrated amniotic membrane for the treatment of gingival recession- a clinical study. J Clin Diagn Res. 2017;11(8):ZC24–ZC8. https://doi.org/10.7860/JCDR/2017/29599.10362.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Chakraborthy S, Sambashivaiah S, Kulal R, Bilchodmath S. Amnion and chorion allografts in combination with coronally advanced flap in the treatment of gingival recession: a clinical study. J Clin Diagn Res. 2015;9(9):ZC98–ZC101. https://doi.org/10.7860/JCDR/2015/12971.6572.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Nevins M, Aimetti M, Parma-Benfenati S, De Angelis N, Yu YH, Kim DM. Treatment of moderate to severe buccal gingival recession defects with placental allografts. Int J Periodontics Restorative Dent. 2016;36(2):171–7. https://doi.org/10.11607/prd.2587.

    Article  PubMed  Google Scholar 

  29. Esteves J, Bhat KM, Thomas B, Varghese JM, Jadhav T. Efficacy of human chorion membrane allograft for recession coverage: a case series. J Periodontol. 2015;86(8):941–4. https://doi.org/10.1902/jop.2014.140025c.

    Article  PubMed  Google Scholar 

  30. Balaji VR, Ramakrishnan T, Manikandan D, Lambodharan R, Karthikeyan B, Niazi TM, et al. Management of gingival recession with acellular dermal matrix graft: a clinical study. J Pharm Bioallied Sci. 2016;8(Suppl 1):S59–64. https://doi.org/10.4103/0975-7406.191970.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Mahn DH. Use of double layer of acellular dermal matrix and modified tunnel technique to treat multiple adjacent gingival recession defects. Compend Contin Educ Dent. 2016;37(8):e9–e12.

    PubMed  Google Scholar 

  32. Taiyeb Ali TB, Shapeen IM, Ahmed HB, Javed F. Efficacy of acellular dermal matrix and autogenous connective tissue grafts in the treatment of gingival recession defects among Asians. J Investig Clin Dent. 2015;6(2):125–32. https://doi.org/10.1111/jicd.12085.

    Article  PubMed  Google Scholar 

  33. Ogata Y, Bui M, Griffin TJ, Hur Y. Use of allograft with platelet concentrate in the treatment of multiple Miller class III gingival recession defects: report of three cases. Int J Periodontics Restorative Dent. 2017;37(3):339–44. https://doi.org/10.11607/prd.2673.

    Article  PubMed  Google Scholar 

  34. Shah R, Sowmya NK, Mehta DS. Amnion membrane for coverage of gingival recession: a novel application. Contemp Clin Dent. 2014;5(3):293–5. https://doi.org/10.4103/0976-237X.137900.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Shetty SS, Chatterjee A, Bose S. Bilateral multiple recession coverage with platelet-rich fibrin in comparison with amniotic membrane. J Indian Soc Periodontol. 2014;18(1):102–6. https://doi.org/10.4103/0972-124X.128261.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rehan M, Khatri M, Bansal M, Puri K, Kumar A. Comparative evaluation of coronally advanced flap using amniotic membrane and platelet-rich fibrin membrane in gingival recession: an 18-month clinical study. Contemp Clin Dent. 2018;9(2):188–94. https://doi.org/10.4103/ccd.ccd_799_17.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Wang HL, Suarez-Lopez Del Amo F, Layher M, Eber R. Comparison of freeze-dried and solvent-dehydrated acellular dermal matrix for root coverage: a randomized controlled trial. Int J Periodontics Restorative Dent. 2015;35(6):811–7. https://doi.org/10.11607/prd.2554.

    Article  PubMed  Google Scholar 

  38. Greenwell H, Fiorellini J, Giannobile W, Offenbacher S, Salkin L, Townsend C, et al. Oral reconstructive and corrective considerations in periodontal therapy. J Periodontol. 2005;76(9):1588–600. https://doi.org/10.1902/jop.2005.76.9.1588.

    Article  PubMed  Google Scholar 

  39. Pietruska M, Skurska A, Podlewski L, Milewski R, Pietruski J. Clinical evaluation of Miller class I and II recessions treatment with the use of modified coronally advanced tunnel technique with either collagen matrix or subepithelial connective tissue graft: a randomized clinical study. J Clin Periodontol. 2019;46(1):86–95. https://doi.org/10.1111/jcpe.13031.

    Article  CAS  PubMed  Google Scholar 

  40. • Tonetti MS, Cortellini P, Pellegrini G, Nieri M, Bonaccini D, Allegri M, et al. Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. J Clin Periodontol. 2018;45(1):78–88. https://doi.org/10.1111/jcpe.12834 A multicenter, multination randomized controlled trial whose results could mimic those obtained in daily practice.

    Article  PubMed  Google Scholar 

  41. Sangiorgio JPM, Neves F, Rocha Dos Santos M, Franca-Grohmann IL, RCV C, Casati MZ, et al. Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: a randomized clinical trial. Part I: clinical outcomes. J Periodontol. 2017;88(12):1309–18. https://doi.org/10.1902/jop.2017.170126.

    Article  PubMed  Google Scholar 

  42. Cardaropoli D, Tamagnone L, Roffredo A, Gaveglio L. Coronally advanced flap with and without a xenogenic collagen matrix in the treatment of multiple recessions: a randomized controlled clinical study. Int J Periodontics Restorative Dent. 2014;34 Suppl 3:s97–102. https://doi.org/10.11607/prd.1605.

    Article  PubMed  Google Scholar 

  43. Stefanini M, Jepsen K, de Sanctis M, Baldini N, Greven B, Heinz B, et al. Patient-reported outcomes and aesthetic evaluation of root coverage procedures: a 12-month follow-up of a randomized controlled clinical trial. J Clin Periodontol. 2016;43(12):1132–41. https://doi.org/10.1111/jcpe.12626.

    Article  PubMed  Google Scholar 

  44. McGuire MK, Scheyer ET. Long-term results comparing xenogeneic collagen matrix and autogenous connective tissue grafts with coronally advanced flaps for treatment of dehiscence-type recession defects. J Periodontol. 2016;87(3):221–7. https://doi.org/10.1902/jop.2015.150386.

    Article  PubMed  Google Scholar 

  45. Vincent-Bugnas S, Borie G, Charbit Y. Treatment of multiple maxillary adjacent class I and II gingival recessions with modified coronally advanced tunnel and a new xenogeneic acellular dermal matrix. J Esthet Restor Dent. 2018;30(2):89–95. https://doi.org/10.1111/jerd.12337.

    Article  PubMed  Google Scholar 

  46. Cieslik-Wegemund M, Wierucka-Mlynarczyk B, Tanasiewicz M, Gilowski L. Collagen matrix with tunnel technique compared to connective tissue graft for the treatment of periodontal recession - randomized clinical trial. J Periodontol. 2016;87:1–15. https://doi.org/10.1902/jop.2016.150676.

    Article  Google Scholar 

  47. Cosgarea R, Juncar R, Arweiler N, Lascu L, Sculean A. Clinical evaluation of a porcine acellular dermal matrix for the treatment of multiple adjacent class I, II, and III gingival recessions using the modified coronally advanced tunnel technique. Quintessence Int. 2016;47(9):739–47. https://doi.org/10.3290/j.qi.a36565.

    Article  PubMed  Google Scholar 

  48. Anderson LE, Inglehart MR, El-Kholy K, Eber R, Wang HL. Implant associated soft tissue defects in the anterior maxilla: a randomized control trial comparing subepithelial connective tissue graft and acellular dermal matrix allograft. Implant Dent. 2014;23(4):416–25. https://doi.org/10.1097/ID.0000000000000122.

    Article  PubMed  Google Scholar 

  49. Maiorana C, Beretta M, Pivetti L, Stoffella E, Grossi GB, Herford AS. Use of a collagen matrix as a substitute for free mucosal grafts in pre-prosthetic surgery: 1 year results from a clinical prospective study on 15 patients. Open Dent J. 2016;10:395–410. https://doi.org/10.2174/1874210601610010395.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Maiorana C, Pivetti L, Signorino F, Grossi GB, Herford AS, Beretta M. The efficacy of a porcine collagen matrix in keratinized tissue augmentation: a 5-year follow-up study. Int J Implant Dent. 2018;4(1):1. https://doi.org/10.1186/s40729-017-0113-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. McGuire MK, Scheyer ET. Randomized, controlled clinical trial to evaluate a xenogeneic collagen matrix as an alternative to free gingival grafting for oral soft tissue augmentation. J Periodontol. 2014;85(10):1333–41. https://doi.org/10.1902/jop.2014.130692.

    Article  PubMed  Google Scholar 

  52. Schallhorn RA, McClain PK, Charles A, Clem D, Newman MG. Evaluation of a porcine collagen matrix used to augment keratinized tissue and increase soft tissue thickness around existing dental implants. Int J Periodontics Restorative Dent. 2015;35(1):99–103. https://doi.org/10.11607/prd.1888.

    Article  PubMed  Google Scholar 

  53. Froum SJ, Khouly I, Tarnow DP, Froum S, Rosenberg E, Corby P, et al. The use of a xenogeneic collagen matrix at the time of implant placement to increase the volume of buccal soft tissue. Int J Periodontics Restorative Dent. 2015;35(2):179–89. https://doi.org/10.11607/prd.2226.

    Article  PubMed  Google Scholar 

  54. Zafiropoulos GG, Deli G, Hoffmann O, John G. Changes of the peri-implant soft tissue thickness after grafting with a collagen matrix. J Indian Soc Periodontol. 2016;20(4):441–5. https://doi.org/10.4103/0972-124X.181245.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Hutton CG, Johnson GK, Barwacz CA, Allareddy V, Avila-Ortiz G. Comparison of two different surgical approaches to increase peri-implant mucosal thickness: a randomized controlled clinical trial. J Periodontol. 2018;89(7):807–14. https://doi.org/10.1002/JPER.17-0597.

    Article  PubMed  Google Scholar 

  56. Cairo F, Barbato L, Tonelli P, Batalocco G, Pagavino G, Nieri M. Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial. J Clin Periodontol. 2017;44(7):769–76. https://doi.org/10.1111/jcpe.12750.

    Article  CAS  PubMed  Google Scholar 

  57. Puzio M, Blaszczyszyn A, Hadzik J, Dominiak M. Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic collagen matrix - 1-year randomised follow-up. Ann Anat. 2018;217:129–41. https://doi.org/10.1016/j.aanat.2017.11.003.

    Article  PubMed  Google Scholar 

  58. Zeltner M, Jung RE, Hammerle CH, Husler J, Thoma DS. Randomized controlled clinical study comparing a volume-stable collagen matrix to autogenous connective tissue grafts for soft tissue augmentation at implant sites: linear volumetric soft tissue changes up to 3 months. J Clin Periodontol. 2017;44(4):446–53. https://doi.org/10.1111/jcpe.12697.

    Article  CAS  PubMed  Google Scholar 

  59. Farina V, Zaffe D. Changes in thickness of mucosa adjacent to implants using tissue matrix allograft: a clinical and histologic evaluation. Int J Oral Maxillofac Implants. 2015;30(4):909–17. https://doi.org/10.11607/jomi.3611.

    Article  PubMed  Google Scholar 

  60. Puisys A, Vindasiute E, Linkevciene L, Linkevicius T. The use of acellular dermal matrix membrane for vertical soft tissue augmentation during submerged implant placement: a case series. Clin Oral Implants Res. 2015;26(4):465–70. https://doi.org/10.1111/clr.12401.

    Article  PubMed  Google Scholar 

  61. Lorenz J, Blume M, Barbeck M, Teiler A, Kirkpatrick CJ, Sader RA, et al. Expansion of the peri-implant attached gingiva with a three-dimensional collagen matrix in head and neck cancer patients-results from a prospective clinical and histological study. Clin Oral Investig. 2017;21(4):1103–11. https://doi.org/10.1007/s00784-016-1868-2.

    Article  PubMed  Google Scholar 

  62. Lim HC, An SC, Lee DW. A retrospective comparison of three modalities for vestibuloplasty in the posterior mandible: apically positioned flap only vs. free gingival graft vs. collagen matrix. Clin Oral Investig. 2018;22(5):2121–8. https://doi.org/10.1007/s00784-017-2320-y.

    Article  PubMed  Google Scholar 

  63. Thoma DS, Alshihri A, Fontolliet A, Hammerle CHF, Jung RE, Benic GI. Clinical and histologic evaluation of different approaches to gain keratinized tissue prior to implant placement in fully edentulous patients. Clin Oral Investig. 2018;22(5):2111–9. https://doi.org/10.1007/s00784-017-2319-4.

    Article  PubMed  Google Scholar 

  64. Schmitt CM, Moest T, Lutz R, Wehrhan F, Neukam FW, Schlegel KA. Long-term outcomes after vestibuloplasty with a porcine collagen matrix (Mucograft((R)) ) versus the free gingival graft: a comparative prospective clinical trial. Clin Oral Implants Res. 2016;27(11):e125–e33. https://doi.org/10.1111/clr.12575.

    Article  PubMed  Google Scholar 

  65. Vellis J, Kutkut A, Al-Sabbagh M. Comparison of xenogeneic collagen matrix vs. free gingival grafts to increase the zone of keratinized mucosa around functioning implants. Implant Dent. 2019;28(1):20–7. https://doi.org/10.1097/ID.0000000000000842.

    Article  PubMed  Google Scholar 

  66. Urban IA, Lozada JL, Nagy K, Sanz M. Treatment of severe mucogingival defects with a combination of strip gingival grafts and a xenogeneic collagen matrix: a prospective case series study. Int J Periodontics Restorative Dent. 2015;35(3):345–53. https://doi.org/10.11607/prd.2287.

    Article  PubMed  Google Scholar 

  67. Papi P, Pompa G. The use of a novel porcine derived acellular dermal matrix (Mucoderm) in peri-implant soft tissue augmentation: preliminary results of a prospective pilot cohort study. Biomed Res Int. 2018;2018:6406051–9. https://doi.org/10.1155/2018/6406051.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Sanz-Martin I, Encalada C, Sanz-Sanchez I, Aracil J, Sanz M. Soft tissue augmentation at immediate implants using a novel xenogeneic collagen matrix in conjunction with immediate provisional restorations: a prospective case series. Clin Implant Dent Relat Res. 2019;21(1):145–53. https://doi.org/10.1111/cid.12696.

    Article  PubMed  Google Scholar 

  69. Zuiderveld EG, Meijer HJA, Vissink A, Raghoebar GM. The influence of different soft-tissue grafting procedures at single implant placement on esthetics: a randomized controlled trial. J Periodontol. 2018;89(8):903–14. https://doi.org/10.1002/JPER.18-0061.

    Article  CAS  PubMed  Google Scholar 

  70. • Tatakis DN, Chambrone L, Allen EP, Langer B, McGuire MK, Richardson CR, et al. Periodontal soft tissue root coverage procedures: a consensus report from the AAP Regeneration Workshop. J Periodontol. 2015;86(2 Suppl):S52–5. https://doi.org/10.1902/jop.2015.140376. This article along with its accompanying systemic review discusses current evidence on effectiveness of various root coverage procedures in managing gingival recession defects.

    Article  CAS  PubMed  Google Scholar 

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  1. Graduate Periodontics, School of Dentistry, University of Louisville, 501 South Preston Street, Louisville, KY, 40202, USA

    Pin-Chuang Lai, Diksha Katwal & Henry Greenwell

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Lai, PC., Katwal, D. & Greenwell, H. Allografts and Xenografts for Periodontal Plastic Surgical Procedures. Curr Oral Health Rep 6, 218–229 (2019). https://doi.org/10.1007/s40496-019-00228-3

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