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Application of Stem Cells for Bone Regeneration in Critical-Sized Defects

  • Dental Stem Cells in Tissue Regeneration (F Setzer, Section Editor)
  • Published:
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Abstract

Purpose of Review

To discuss tissue bioengineering for critical-sized bone defects. To review the current stem cells that are in use and to describe the importance of an animal model for studying critical-sized bone defects.

Recent Findings

Bone marrow mesenchymal stem cells (MSCs) are well investigated. Recently, other sources of MSCs have been identified and studied in critical-sized bone defects. As for animal models, several have been used to evaluate the use of stem cells in promoting regeneration in critical-sized bone defects. This review specifically focuses on one of the most widely used and accepted models, the rodent calvarium.

Summary

Stem cell therapy is promising for bone regeneration, especially for critical-sized bone defects. Additional studies are needed to better understand both the properties and mechanisms of the different types of stem cells, and to develop animal models that mimic human biology.

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Authors and Affiliations

  1. Department of Anatomy & Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA, 19104, USA

    Shuying Yang

  2. Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Brian P. Ford

  3. Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Zahra Chinipardaz

  4. School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Justin Kirkwood

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  1. Shuying Yang
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  2. Brian P. Ford
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Correspondence to Shuying Yang.

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This article is part of the Topical Collection on Dental Stem Cells in Tissue Regeneration

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Yang, S., Ford, B.P., Chinipardaz, Z. et al. Application of Stem Cells for Bone Regeneration in Critical-Sized Defects. Curr Oral Health Rep 5, 286–294 (2018). https://doi.org/10.1007/s40496-018-0193-z

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  • DOI: https://doi.org/10.1007/s40496-018-0193-z

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