Abstract
This systematic review summarizes the evidence about toe walking (TW) interventions in persons with autism. Following the PRISMA guidelines, a systematic search of MEDLINE, CINAHL, PsycINFO, The Cochrane Library, Google Scholar, and Opengrey was performed. Nine articles (all case reports or case series) were included. Methodological quality was assessed using the Mayo Evidence-Based Practice Centre tool. The included studies considered 17 subjects (16 males; age range: 4–15 years). All studies reported a reduction of TW frequency, but the follow-up was lacking in seven studies. There is a lack of high-quality studies with a sufficiently large and well-characterized sample to assess the effectiveness of TW interventions in autistic persons. These findings strongly support the need for further research in this area.
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Introduction
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder affecting 1 in 44 children (Maenner et al., 2021), resulting in an impairment of socio-communicative interaction, restricted interests, and repetitive behavior (American Psychiatric Association, 2013). Diagnostic criteria are described in the diagnostic and statistical manual of mental disorders–5th edition (American Psychiatric Association, 2013). Despite motor impairments are not currently included in the evaluation and diagnostic criteria of ASD, there is rising evidence that persons with ASD also have motor impairments. An epidemiological study reported a prevalence of 35.4% for motor impairments among 2,084 individuals with ASD (Licari et al., 2020). The authors observed a decline in motor scores with increasing age of diagnosis and found motor difficulties in children with (1/2 children) and without (1/3 children) intellectual impairments. The study of motor impairments in persons with autism is peculiar because motor-related impairments may become a significant barrier to a child’s further social communication development as well as adaptive functioning (Bedford et al., 2016; Macdonald et al., 2013; Ohara et al., 2020). Moreover, motor delays can be one of the earliest markers of ASD (Biscaldi et al., 2014; Harris, 2017; Lloyd et al., 2013). Gross-motor function impairments have been reported in persons with ASD as visuomotor coordination deficits (Fleury et al., 2013; Kushki et al., 2011), bilateral coordination disorders (Green et al., 2009; Kaur et al., 2018; McPhillips et al., 2014), or difficulties with fine motor skills (Bhat et al., 2011; LeBarton & Iverson, 2013). Furthermore, postural capacity was found to be impaired in ASD individuals both with (Kohen-Raz et al., 1992; Perin et al., 2020) and without intellectual disability (Doumas et al., 2016; Fournier et al., 2010 and, 2014). Gait was found impaired in autistic individuals in terms of increased step width (Eggleston et al., 2020; Shetreat-Klein et al., 2014), more variable stride length (Nobile et al., 2011; Rinehart et al., 2006), differences in variability in each gait sub-phase (Eggleston et al., 2020), and toe walking (TW) (Accardo et al., 2014). TW is a diagnosis given to subjects who persist in walking on their toes after they should typically have achieved a heel-toe gait, and it should resolve by 3–7 years of age (Shetreat-Klein et al., 2014). To be diagnosed, TW should be manifested for more than 6 months (Accardo et al., 2014).
TW is the most common deformity in children with bilateral spastic cerebral palsy, with 83.3% (Horsch et al., 2019). TW can also be found in neuromuscular disorders (Hyde et al., 2000). The prevalence varies depending on the neuromuscular disorder; e.g., in Duchenne muscular dystrophy and Charcot-Marie-Tooth disease, TW has been identified as a relevant clinical concern (Rose et al., 2010). Furthermore, TW has also been described in the healthy population. Engelbert et al. (2011) reported a TW prevalence of 12% in a sample of 362 healthy subjects (8–20 years old), Engström and Tedroff (2012) described a TW prevalence of roughly 4.5% in 5 years old typically developed children, and Shetreat-Klein et al. (2014) reported a prevalence of 3% in healthy children ranging from 22 months to 10 years. Ming et al. (2007) and Barrow et al. (2011) reported a TW prevalence of 20% in autistic individuals. Recently, a broad retrospective study (Leyden et al., 2019) identified a higher prevalence of TW (8.4%) in ASD individuals than in typically developing children (0.47%). TW in ASD seems to be influenced by the severity of the diagnosis, with a 10% increased incidence of tight heel cords present in autistic children compared with a 3% increased incidence in children diagnosed with Asperger’s (Barrow et al., 2011). Interestingly, Leyden et al. (2019) found no significant differences in TW prevalence in persons with autism with and without intellectual disability.
TW can be present with different levels of severity (Accardo & Barrow, 2015). Some authors described TW severity as intermittent or persistent (Ming et al., 2007); others graded TW using subjects’ history and observation (absent, present in the past, intermittently present, or persistent). Tip toe behavior (TTB) can be present also during standing (Valagussa et al., 2017; Weber, 1978) and/or running (Robert, 2011; Valagussa et al., 2017). Valagussa et al. (2017) highlighted the existence of three mutually exclusive clinical patterns of TTB: (1) during standing, walking, and running; (2) during walking and running; and (3) only when running. The persistence of TW may lead to a higher risk of falling (Caselli et al., 1988), associated with a social or cosmetic impact (Pendharkar et al., 2008), and may affect the child’s functional capabilities and quality of life (Calhoun et al., 2011). Moreover, it is suggested that TW persistence in autistic individuals may shorten the Achilles tendon (Accardo et al., 2014; Valagussa et al., 2020).
The etiology of TW in autism is still less understood (Accardo et al., 2014). Weber (1978) suggested that “TW arise from the fixation of a normal transient stage of development.” Capute et al. (1979) proposed TW as a residual of a primitive walking pattern (e.g., positive support reflex or tonic labyrinthine reflex). Accardo et al. (2014) suggested TW could be related to a sensory disorder or vestibular issues.
A recent systematic review reported that posterior ankle–foot orthoses (AFO) increased ankle dorsiflexion at initial contact in children with cerebral palsy and TW (Lintanf et al., 2018). Additionally, surgery was considered adequate to improve TW in this condition (Rutz et al., 2020). Some RCTs have shown the effectiveness of interventions for TW in healthy individuals (idiopathic toe walking, ITW). Herrin and Geil (2016) compared the use of ankle–foot orthoses to full-length in-shoe orthoses. Sätilä et al. (2016) compared conservative care to conservative treatments combined with botulinum toxin injections. Engström et al. (2013) assessed the effectiveness of combining casts and botulinum toxin injections compared to casts alone in reducing TW.
Treatment of TW in autism draws from the anecdotal experience of treating children with other neurodevelopmental disabilities such as cerebral palsy and those with ITW (Accardo et al., 2014). Recently, Leyden et al. (2019) conducted a comprehensive retrospective analysis to determine how patients with and without ASD who have persistent TW are treated with various techniques. Among 2,221,009 pediatric patients included, 5,739 had a diagnosis of ASD, of which 484 also had a diagnosis of persistent TW (8.4% of subjects with ASD). On the other hand, 10,840 subjects presented a persistent TW without a neuro-orthopedic condition or ASD (i.e., typically developing children). The 57.2% (n = 5,995) of these subjects did not report toe-walking interventions; 3,989 (38.1%) underwent physical therapy, 374 (3.6%) serial casting, and 122 (1.2%) underwent surgical correction. Concerning the individuals with ASD presenting TW, n = 287 (59.3%) were referred to physical therapy and treated with stretching exercises at the lower limbs, specifically to the Achilles tendon; n = 36 (7.4%) underwent serial casting; n = 16 (3.3%) received surgery while the treatment was not reported in the remaining 30% (n = 145) of subjects. When the authors compared the outcomes of individuals with ASD with TW versus typically developing children with TW, a significant difference (p = 0.041) was shown in favor of ASD subjects. Despite these interventions, the 63.8% (n = 183) of the ASD patients that were treated with physical therapy, the 47.2% (n = 17) of patients that were treated with casting, and the 75% (n = 12) of the patients that were treated surgically continued to toe-walk within 2 years of treatment. Therefore, from a clinical and research standpoint, it is relevant to know if all these interventions are supported by the current evidence about the TW management for persons with autism. To our knowledge, TW treatments were not systematically searched (Valagussa et al., 2018), and the methodological quality of intervention studies on TW treatments was not assessed. Hence, the current study aimed to summarize the evidence on conservative, pharmacological, and surgical interventions for treating TW in autistic individuals by conducting a systematic review. Specifically, the research question for this study was: What is the evidence for the effect of interventions on TW for individuals with autism spectrum disorder? A systematic review of the literature was designed to answer this question, because it is recognized as the appropriate research method that objectively investigates and summarizes the existing evidence about a specific body of research. This systematic review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA 2020) Statement (Page et al., 2021).
Methods
Protocol and Registration
The systematic review was a-priori registered on the International Prospective Register of Systematic Reviews (PROSPERO: number CRD42020176335).
Data Sources and Searches
The search was undertaken on MEDLINE (via PubMed), CINAHL, PsycINFO, The Cochrane Library, Google Scholar, and OpenGrey from databases inceptions until August 2021. Reference lists of included studies were controlled to identify additional studies. Medical subject headings (MeSH) and non-MeSH search terms were used, including synonyms for the keywords “toe walking” and “autism spectrum disorder.” The search query was defined by two researchers (G.V. and D.P.). The search strategy was developed for the MEDLINE database and then was adapted for the others. No restrictions regarding language, year of publication, and age of population were applied. Specifics on the search queries for all the databases are available in Supplementary Material 1. On Google Scholar, two searches were run using two different keyword combinations, and then the first 100 hints of each of the two searches were considered (Chiarotto et al., 2016; Piscitelli et al., 2021).
Criteria for Considering Studies for This Review
Participants: as autism diagnostic criteria have changed over time, this systematic review considered any recognized diagnostic criteria for autistic individuals, i.e., from the “Kanner’s autism” diagnosis to the different autism diagnoses labeled in editions of the diagnostic and statistical manual of mental disorders. Studies about the treatment of TW in persons with autism were considered without age limitation. Individuals should have had TW for more than 6 months, should walk with or without a heel-toe gait, and whether or not limited dorsiflexion of the ankle joint.
Interventions: conservative and/or surgical interventions were included.
Comparator(s)/control: comparisons of any intervention versus another or no intervention were considered.
Outcome measures: the primary outcome was defined as the decreasing of TW assessed by the time or the number of feet in TW (i.e., percentage of the time or number of feet engaged in TW during testing or monitoring), evaluated by objective and/or subjective judgment self-reported by the autistic individuals, caregivers, and healthcare professionals. Additional outcomes were (1) changes in Achilles tendon length expressed as improvement of ankle range of motion (passive and/or active), (2) recurrence of TW post-treatment, and (3) adverse events.
Types of studies: intervention study designs such as single-subject design, case reports, case series, single or double cohort clinical trials, and (non-)randomized (un-)controlled trials investigating the effect of the TW interventions were included. Furthermore, studies should be published in peer-reviewed journals. Abstracts, conference proceedings, and dissertations were excluded.
Study Selection
After deleting the duplicated records, the studies were screened independently by two authors (V.P. and S.B.) to identify records that potentially met the inclusion criteria outlined above. The full text was retrieved and independently assessed for eligibility by two authors (V.P. and S.B.). Any disagreement was resolved through discussion with a third reviewer (G.V.).
Assessment of Methodological Quality of Included Studies
Two authors (G.V. and D.P.) independently evaluated the methodological quality of the included studies. As all articles included in this systematic review were case reports or case series, the framework for appraisal, synthesis, and application of evidence developed by Murad et al. (2018) was used. This instrument considers four domains (selection, ascertainment, causality, and reporting) for a total of eight questions in order to assess the methodological quality (Table 1). Any disagreement between the two authors was resolved through discussion until consensus was reached or discussion with a third author (E.G.). Moreover, all included studies were independently assessed for accuracy, transparency, and usefulness of case reports using the CARE (CAse REport) guidelines checklist for case studies (Gagnier et al., 2013). The CARE guidelines is a 13-item checklist developed by an international expert panel to provide a framework to guide the completeness and transparency of case reports (See Table S1 for items description).
Data Extraction
After the initial assessment for eligibility, two reviewers (V.P. and S.B.) independently extracted the data from the included studies. We resolved discrepancies through discussion and, when necessary, by discussing with a third reviewer (G.V.). Since all the included studies were case reports or case series, the results were summarized qualitatively through a narrative synthesis of the findings. The following information was extracted: authors and year of publication, study design, and population characteristics (sample number, age, sex, diagnostic criteria used for ASD diagnosis, ASD severity, presence/absence of intellectual disability, language level, comprehension ability, comorbidities, and previous TW treatment). Moreover, TW treatment data were summarized as follows: study aim, type of intervention, device/technique employed, TW assessment methods, outcome measures, time estimate assessments (initial assessment, final assessment, presence/absence of follow-up), and results.
Results
Study Selection
The search strategy identified 619 studies. Nine eligible studies were identified (Fig. 1).
Assessment of the Methodological Quality of the Included Studies
Methodological quality assessment is presented in Table 1. Two studies (Barkocy et al., 2017; Marcus et al., 2010) satisfied 4 of 8 questions, six studies (Persicke et al., 2014; Hodges et al., 2018; Wilder et al., 2020; Hodges et al., 2019; Kratz, 2020; Barkocy et al., 2021) met 3 of 8 questions, and one study fulfilled only one question (Shaw & Soto-Garcia, 2021). The selection domain was met in one study (Barkocy et al., 2021); instead, the ascertainment domain (i.e., exposure and outcome) was satisfied all studies except in one study (Shaw & Soto-Garcia, 2021). The causality domain was not entirely satisfied in any study, and the reporting domain was judged as present in 7 studies (Marcus et al., 2010; Persicke et al., 2014; Barkocy et al., 2017; Hodges et al., 2018; Wilder et al., 2020; Hodges et al., 2019; Shaw & Soto-Garcia, 2021; Barkocy et al., 2021).
The CARE assessment is detailed in Table S1 (Supplementary Material 2).
Study Characteristics
The details of the study characteristics are described in Table S2 (Supplementary Material 2). All the included studies were case reports or case series aimed to assess the effectiveness of a conservative intervention on TW frequency in persons with ASD. The included studies enrolled a total of 17 participants (16 males; age range: 4–15 years). One included study specified the diagnostic criteria used and the ASD severity of the individuals (Persicke et al., 2014). One study reported the presence of “moderate intellectual disability” in all the three involved participants. Kratz (2020) described the presence of “cognitive deficit” without the characterization of the impairment. The remaining studies (n = 7) did not specify the participants’ presence/absence of intellectual disability or intelligence quotient. No study reported the intellectual disability assessment method.
Seven included studies out of nine reported the language levels of the participants (Marcus et al., 2010; Persicke et al., 2014; Barkocy et al., 2017; Hodges et al., 2018, 2019; Wilder et al., 2020; Kratz, 2020). Comprehension ability was described in 5 articles; two studies described that the participants were not able to understand verbal instructions (Kratz, 2020; Persicke et al., 2014), while the subjects involved in 3 included studies had no comprehension problems (Barkocy et al., 2017; Hodges et al., 2018, 2019). Finally, four studies did not report the comprehension level (Marcus et al., 2010; Wilder et al., 2020; Shaw & Soto-Garcia, 2021; Barkocy et al., 2021).
Two studies reported the presence of other co-morbidities as mild cerebral palsy with epilepsy (Marcus et al., 2010) and dyspraxia and hypotonia (Kratz, 2020), while all the other studies did not specify the presence/absence of co-morbidities.
Seven out of seventeen participants had previous treatments because of TW persistence (Barkocy et al., 2017; Hodges et al., 2018; Kratz, 2020; Marcus et al., 2010; Persicke et al., 2014; Shaw & Soto-Garcia, 2021), but the proposed interventions did not influence it. Nine out of seventeen participants were not subjected to previous intervention for TW (Marcus et al., 2010; Wilder et al., 2020; Barkocy et al., 2021). Hodges’ study (2019) did not report this information.
Toe Walking Interventions
The details about the interventions are described in Table 2.
Type of Interventions
All the included studies assessed the effectiveness of conservative interventions. Barkocy et al., (2017 and 2021) used a serial casting approach followed by ankle–foot orthosis. Kratz (2020) utilized a single lymphatic drainage treatment, while Shaw and Soto-Garcia (2021) treated TW using cognitive-motor dual-tasking and primitive reflex integration exercises. The remaining five studies used behavioral treatments. In two out of five studies, acoustic feedback using “GaitSpot Auditory Shoe Squeakers” associated with positive reinforcement (verbal or tactile or small edible as Chipsticks) was proposed (Marcus et al., 2010; Wilder et al., 2020). Persicke et al. (2014) and Hodges et al. (2019) used a method for teaching behavior through positive reinforcement by a conditioned auditory stimulus (i.e., a “click” sound) to reinforce correct behaviors: the “TAGteach®” ™ method. The auditory stimulus was paired with an already established reinforcing item (small edible as Chipsticks or verbal or a favorite object) so that the “click” sound functions as a conditioned reinforcer. Finally, Hodges et al. (2018) extended previous research on stimulus control‐based interventions to TW on a child with autism, using a wristband as a discriminative stimulus: in the presence of the wristband, appropriate walking was praised and TW was reprimanded.
Toe Walking Assessment Methods
Most of the included studies used a video recording system to assess TW (Hodges et al., 2018, 2019; Marcus et al., 2010; Persicke et al., 2014; Wilder et al., 2020). Marcus et al. (2010) also employed pen and paper on a recording sheet to assess toe-walking steps in one of the three subjects involved in their study. Barkocy et al. (2017) used both gait analysis equipment and two scales (i.e., the Functional Mobility Scale and the Observational Gait Scale). Later, Barkocy et al. (2021) used both gait analysis equipment and two scales (i.e., the Functional Mobility Scale and the Patient Specific Function Scale). Kratz (2020) conducted the assessment through clinical observations and described the mobility skills using the Pediatric Evaluation of Disability Inventory; moreover, Kratz (2020) took photographs to record lower limbs alignment and feet placement before and after treatment. Finally, Shaw and Soto-Garcia (2021) used a clinical observation “based on quantifiable judgments by the child, parent, or healthcare professional.”
Toe Walking Outcome Measures
The outcome measures were different across the included studies. For the details of the outcome measure used in each study, see Table 2. Barkocy et al. (2017) used the Observational Gait Scale score, the Functional Mobility Scale score, the passive end-range ankle dorsiflexion angle (with the knee extended), and the kinematic data obtained using a gait analysis system. Later, Barkocy et al. (2021) used the Patient Specific Function Scale score, the Functional Mobility Scale score, the passive end-range ankle dorsiflexion angle (with the knee extended), and the kinematic data obtained using a gait analysis system. Kratz (2020) used as outcomes a clinical observation supported by photos and the mobility skills assessment using the mobility subsection of the Pediatric Evaluation of Disability Inventory. Marcus et al. (2010) calculated the percentage of 10-s intervals in 10-min sessions in which each participant engaged TW, dividing the number of occurrences of TW by the total number of 10 s windows TW exhibited. Hodges et al. (2018) and Wilder et al. (2020) used the percentage of steps engaged in TW during each assessment session as an assessment method, while Persicke et al. (2014) and Hodges et al. (2019) used the percentage of appropriate steps. Shaw and Soto-Garcia (2021) considered as outcome measure the time spent on heel-toe walking and the occurrence of falling downstairs.
Study Results
Both pre- and post-treatment assessment details for all the included studies are reported in Table S3 (Supplementary Material 2). Serial casting followed by ankle–foot orthosis improved the administered functional scale scores, end-range passive ankle dorsiflexion range of movement, and the spatial and temporal parameters of gait measured by motion capture system (Barkocy et al., 2017 and 2021). A single treatment of manual lymphatic drainage on the lower limbs resulted in a full-feet placement on the floor with bilateral neutral dorsiflexion, a full-foot contact during gait, and an improvement in the mobility skills subsection of the Pediatric Evaluation of Disability Inventory (Kratz, 2020). Shaw and Soto-Garcia (2021) proposed a treatment based on cognitive-motor dual-tasking and primitive reflex integration exercises that reduced TW. Both the patient and mother stated that “he is now more comfortable within going downstairs and has not fallen since the second visit.”
Behavioral treatments produced a TW improvement. The GaitSpot Auditory Shoe Squeakers (Marcus et al., 2010; Wilder et al., 2020), the use of a wristband (Hodges et al., 2018), and the TAGteach® (Hodges et al., 2019; Persicke et al., 2014) administered with or without positive reinforcement technique ± corrections reduced TW in the autistic individuals involved in the studies. Note that, in Marcus et al. (2010) study, one-third of the subjects completed the previously planned study phases.
Follow-up
Barkocy et al. (2017) conducted a 2-year follow-up. Notably, the authors reported that the subjects continued to use the ankle–foot orthosis between the end of the study and the follow-up. Kratz (2020) performed a follow-up assessment after 1 year; the author described that the subject “continued with long term intensive occupational therapy” in the time between the end of the study and the follow-up. All the other studies (Hodges 2018, 2019; Marcus et al., 2010; Persicke et al., 2014; Wilder et al., 2020) did not report a follow-up.
Adverse Events and Drop-out
Two individuals of Marcus’ study (Marcus et al., 2010) and one subject of Wilder’s study (Wilder et al., 2020) did not complete all treatment’s study phases. One subject was unable to attend the study due to an injury unrelated to the study. The other could not reach the criteria established to complete all treatment’s phases (Marcus et al., 2010). In Wilder et al. (2020) study, a subject had an unrelated medical issue, and the authors were unable to conduct the final study phase. Finally, the data collection protocol was modified for one participant of Barkocy et al. study (Barkocy et al., 2021) as the child experienced an adverse event at school that produced anxiety. For this reason, the data were collected for pre-intervention and post-intervention, the clinical evaluation was executed at home while the child was sleeping, and casting was done in the home environment.
Discussion
Study Design and Study Sample Characteristics
This systematic review aimed to present the current evidence regarding intervention effectiveness for TW in persons with autism. Despite a comprehensive search strategy, only nine studies were identified. All the included studies had a case report or case series study design and considered a total of 17 autistic individuals (16 males) ranging from 4 to 15 years. Only one out of nine studies (Persicke et al., 2014) sufficiently described the ASD diagnostic criteria and severity. Moreover, only two out of nine studies reported the presence/absence of comorbidities and gave information about intellectual disability (see CARE checklist assessment—Table S1 and Table S2) (Kratz, 2020; Marcus et al., 2010) without specifying the assessment methodology. Seven out of nine studies gave information about participants’ language level, which was significantly diversified between study participants. Also, comprehension ability was found heterogeneous between studies. Even though TW is thought as a phenomenon related to sensory disturbance (Accardo et al., 2014; Valagussa et al., 2017), we noted that none of the included studies planned to assess it. Therefore, the individuals’ deficit characteristics and severity were not clearly stated. All these findings together highlight the need to conduct higher quality design studies. Moreover, since an extreme variability of clinical manifestation characterizes ASD, greater relevance should be given for a better characterization of the sample when planning future studies regarding TW treatment, as previously suggested by Fournier et al. (2010).
Toe Walking Interventions
Four types of treatments were proposed to decrease TW in persons with autism: (1) behavioral interventions (Marcus et al., 2010, Persicke et al., 2014; Hodges et al., 2018; Wilder et al., 2020; Hodges et al., 2019), (2) use of serial casting followed by ankle–foot orthoses (Barkocy et al., 2017 and 2021), (3) use of a lymphatic drainage technique (Kratz, 2020), and (4) use of cognitive-motor dual-tasking and primitive reflex integration exercises (Shaw & Soto-Garcia, 2021).
Among the proposed behavioral interventions, two studies (six subjects) evaluated the efficacy of using GaitSpot Auditory Squeaker (Marcus et al., 2010; Wilder et al., 2020). This object was positioned under the participant’s heel inside or under the sole of both shoes. When the subject walked adequately, the pressure given by the heel pushes the device, emitting auditory feedback. This procedure and edible and vocal positive reinforcement appeared to reduce the frequency of TW in the participants of Marcus et al. (2010) study. Although Wilder et al. (2020) aimed to study the efficacy of the GaitSpot device without adding other reinforcement components, only one out of three included subjects seemed to reduce TW only using this device. The other two participants also needed to introduce further treatment strategies (i.e., an edible reinforcement alone and an edible reinforcement plus manual correction). Thus, it would be clinically valuable to conduct future research to investigate the responders’ characteristics to the GaitSpot treatment alone compared to responders to GaitSpot associated with another reinforcement. Moreover, Wilders et al. (2020) recognize as a limitation that they did not assess the extent to which the intervention effects generalized in the absence of the GaitSpot Auditory Squeaker. On the other hand, the squeaker sound could be valuable feedback because it could be used without healthcare professionals.
Two studies (Hodges et al., 2019; Persicke et al., 2014) adopted another behavioral correction technique called TAGteach® in addition to reinforcement procedures. It consists of using a “clicker” device manually squeezed by the examiner when the subject walks properly. For the two participants of the studies, there was a reduction in the percentage of TW. The authors added a manual correction with pressure on one of the two participant’s shoulders to induce his heels to touch the ground (Persicke et al., 2014). Compared to the treatment with GaitSpot, TAGteach® requires another subject that makes the “click” sound every correct step. Moreover, being a procedure that requires careful and continuous observation by the examiner, it is easily prone to error (e.g., the examiner does not notice that a correct step has been taken and, as a consequence, does not squeeze the clicker or the examiner squeeze the device even when there is no complete support of the heel on the ground). A limit of this type of intervention could be using this device in the context of everyday life. It may interfere with daily social activities (e.g., school) as the repeated “click” sound emission could be a nuisance in a quiet environment or, conversely, it may not be heard in a noisy environment. Moreover, it could be less socially acceptable because the TAGteach® technique is also used in other contexts, including animal training (TAGteach® International, 2012).
Hodges et al. (2018) adopted a type of behavioral intervention based on stimulus control using a wristband as a tactile stimulus worn on the participant’s wrist. The tactile stimulus praised the subject when he was walking properly while giving a reprimand when showing TW. Compared to the previous ones (Hodges et al., 2019; Persicke et al., 2014), this type of intervention could be more acceptable in a social context.
Three other different treatment types were described. Serial casting followed by ankle–foot orthoses was proposed to increase the dorsiflexion of the tibiotarsal joint and reduce TW in two studies (Barkocy et al., 2017 and 2021). In particular, Barkocy et al. (2021) demonstrated the feasibility of such treatment in a population of autistic children even if a clear characterization of the study sample was missing. On the other hand, compared to the previous treatments, this type of intervention is more invasive since it limits joint mobility and the motor activity of the subjects. The second described treatment is specific lymphatic drainage called the “Chikly method” (Kratz, 2020). The author reported that the subject ultimately resolved its TW after one lymphatic drainage session. However, the author did not provide quantitative data. This technique showed different limits. Firstly, to be correctly applied, it requires specific healthcare professional training. Moreover, the underlying hypothesis that drove this intervention was not clearly stated. Notably, since about 60% of ASD subjects seem to show a sensorial disturbance (Tomchek & Dunn, 2007), including sensory deficits with characteristics of hypersensitivity, the application of manual technique or serial casting could create a sense of discomfort in a subject with these features, and an adverse reaction of avoidance or agitation could be provoked (Miller et al., 2007). Data about the sensory profile of the subjects involved in all the included studies were not provided.
The last treatment consisted of a series of cognitive-motor dual-tasking and primitive reflex integration exercises (Shaw & Soto-Garcia, 2021) executed during the treatment and prescribed as an exercise to perform at home. The authors recognized as a significant limitation of their study the lack of objective measurements to detect the effectiveness of treatments.
A limit presented by five out of nine studies is the absence of follow-up, not allowing for evaluating the efficacy of the treatments in the medium-long term. Moreover, in studies where a follow-up was planned, other interventions have been applied between the end of the treatment and the follow-up. Thus, it is not possible to infer that the reduction of TW frequency directly depends on the investigated treatment.
All the retrieved studies considered only conservative interventions. Despite pharmacological (i.e., botulinum toxin) and surgical interventions (i.e., muscle lengthening) are currently used in clinical practice to treat TW in persons with autism (Leyden et al., 2019), no studies about pharmacological and surgical effectiveness were found. All this suggests the need to plan studies about pharmacological and surgical interventions specifically addressed to persons with autism, as also previously suggested by Bartoky et al. (2017). Notably, as reported by a recent Cochrane review (Caserta et al., 2019), behavioral treatments and serial casting were also proposed to reduce ITW. In particular, the authors reported the results of a study (Engström et al., 2013) where the effectiveness of serial casting alone was compared to the use of serial casting associated with botulinum toxin: both procedures reduced ITW, but it was not possible to define the best treatment option.
The methodological quality of the included studies was assessed through the framework developed by Murad et al. (2018). This checklist does not provide a total score, and no cut-offs are yet available to classify the methodological quality. However, only two studies met half of the domains (i.e., four out of eight); one domain (i.e., selection domain) was only met in one study, while another domain (i.e., randomity) was not met in any included case report. Therefore, the methodological quality of the included studies may have some flaws.
Limitations and Strengths of the Study
Publication bias is a potential limitation of any review. However, a strong publication bias is unlikely in this review as several databases were queries, and no language or year of publication restrictions were applied. On the other hand, to our knowledge, this is the first systematic review addressed to summarize the evidence about the treatment of TW in ASD.
Research Implications
This systematic review evidenced several important and helpful points that should be incorporated and considered in future studies. Clinicians and researchers should better characterize the study sample in terms of conditions that may impact TW assessment and treatment. The following characteristics should be described: (I) ASD diagnostic criteria and ASD severity; (II) the presence/absence of comorbidities; (III) information about the intellectual disability level/IQ score and the methodology used to assess it; (IV) information about the ability of language comprehension and expression; (V) information about previous treatments for TW and the obtained results; and (VI) information about sensory characteristics. Additionally, there is a need to perform higher-quality studies, such as prospective cohort studies and/or randomized controlled trials. Researchers should consider planning an effective follow-up strategy to evaluate the efficacy of the treatments in the medium-long term. Finally, no studies concerning pharmacological (e.g., botulinum toxin) and surgical interventions (e.g., muscle lengthening) for treating TW in autistic individuals were found; therefore, studies are needed to investigate their effect specifically in individuals with ASD.
A significant drawback in designing RCTs for interventions to improve TW in autism is that the etiology of TW is not well understood (Accardo et al., 2014). Therefore, the developed treatments tend to be symptom-based rather than etiology-based. Furthermore, the interventions presented in our systematic review should be investigated to verify their applicability to subjects with greater severity of ASD. Researchers should include individuals with a broad range of populations (e.g., from mild to severe intellectual disability) to enhance the generalizability of their studies. Concerning the outcomes, there is no gold standard measure for assessing interventions for TW. The most used outcome measure seems to be the time or the number of feet in TW (i.e., percentage of the time or number of feet engaged in TW during testing or monitoring), evaluated by objective and/or subjective measures, or kinematically changes of gait parameters measured by a motion capture system. Additionally, an indirect outcome measure is the quantity of foot range of movement in dorsiflexion performed with both the knee extended and flexed. To this end, the scientific community should set the standard for the outcomes used for assessing the effectiveness of treatment for TW, thus facilitating researchers and clinicians to use similar assessments.
Conclusion
There is a lack of studies with appropriate study designs and a sufficiently large and well-characterized sample to assess the effectiveness of conservative treatments for TW in persons with autism. The review highlights the absence of studies about the effectiveness of pharmacological and surgical interventions on TW individuals with ASD. The findings strongly support the need for further higher-quality studies addressed to evaluate the effectiveness of conservative, pharmacological, and surgical interventions for TW in ASD.
References
Accardo, P. J., & Barrow, W. (2015). Toe walking in autism: Further observations. Journal of Child Neurology, 30(5), 606–609. https://doi.org/10.1177/0883073814521298
Accardo, P.J., Monasterio, E., & Oswald, D. (2014). Toe walking in autism, in V.B. Patel, V.R. Preedy, & C.R. Martin (Eds.), Comprehensive guide to autism (pp. 519–532). New York, NY: Springer. https://doi.org/10.1007/978-1-4614-4788-7
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub.
Barkocy, M., Dexter, J., & Petranovich, C. (2017). Kinematic gait changes following serial casting and bracing to treat toe walking in a child with autism. Pediatric Physical Therapy : THe Official Publication of the Section on Pediatrics of the American Physical Therapy Association, 29(3), 270–274. https://doi.org/10.1097/PEP.0000000000000404
Barkocy, M., Schilz, J., Heimerl, S., Chee, M., Valdez, M., & Redmond, K. (2021). The effectiveness of serial casting and ankle foot orthoses in treating toe walking in children with autism spectrum disorder. Pediatric Physical Therapy : THe Official Publication of the Section on Pediatrics of the American Physical Therapy Association, 33(2), 83–90. https://doi.org/10.1097/PEP.0000000000000784
Barrow, W. J., Jaworski, M., & Accardo, P. J. (2011). Persistent toe walking in autism. Journal of Child Neurology, 26(5), 619–621. https://doi.org/10.1177/0883073810385344
Bedford, R., Pickles, A., & Lord, C. (2016). Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder. Autism Research : Official Journal of the International Society for Autism Research, 9(9), 993–1001. https://doi.org/10.1002/aur.1587
Bhat, A. N., Landa, R. J., & Galloway, J. C. (2011). Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders. Physical Therapy, 91(7), 1116–1129. https://doi.org/10.2522/ptj.20100294
Biscaldi, M., Rauh, R., Irion, L., Jung, N. H., Mall, V., Fleischhaker, C., & Klein, C. (2014). Deficits in motor abilities and developmental fractionation of imitation performance in high-functioning autism spectrum disorders. European Child & Adolescent Psychiatry, 23(7), 599–610. https://doi.org/10.1007/s00787-013-0475-x
Calhoun, M., Longworth, M., & Chester, V. L. (2011). Gait patterns in children with autism. Clinical Biomechanics (bristol, Avon), 26(2), 200–206. https://doi.org/10.1016/j.clinbiomech.2010.09.013
Capute, A. J., Accardo, P. J., Vining, E. P. G., Rubenstein, J. E., & Harryman, S. (1979). Primitive reflex profile. University Park Press.
Caselli, M. A., Rzonca, E. C., & Lue, B. Y. (1988). Habitual toe-walking: Evaluation and approach to treatment. Clinics in Podiatric Medicine and Surgery, 5(3), 547–559.
Caserta, A. J., Pacey, V., Fahey, M., Gray, K., Engelbert, R. H., & Williams, C. M. (2019). Interventions for idiopathic toe walking. The Cochrane database of systematic reviews, 10(10), CD012363. Advance online publication. https://doi.org/10.1002/14651858.CD012363.pub2
Chiarotto, A., Maxwell, L. J., Terwee, C. B., Wells, G. A., Tugwell, P., & Ostelo, R. W. (2016). Roland-Morris Disability Questionnaire and Oswestry Disability Index: Which has better measurement properties for measuring physical functioning in nonspecific low back pain? Systematic Review and Meta-Analysis. Physical Therapy, 96(10), 1620–1637. https://doi.org/10.2522/ptj.20150420
Doumas M, McKenna R, Murphy B. (2016). Postural control deficits in autism spectrum disorder: The role of sensory integration. Journal of Autism and Developmental Disorders, 46(3):853–61. https://doi.org/10.1007/s10803-015-2621-4.
Eggleston, J. D., Harry, J. R., Cereceres, P. A., Olivas, A. N., Chavez, E. A., Boyle, J. B., & Dufek, J. S. (2020). Lesser magnitudes of lower extremity variability during terminal swing characterizes walking patterns in children with autism. Clinical Biomechanics (bristol, Avon), 76, 105031. https://doi.org/10.1016/j.clinbiomech.2020.105031
Engström, P., & Tedroff, K. (2012). The prevalence and course of idiopathic toe-walking in 5-year-old children. Pediatrics, 130(2), 279–284. https://doi.org/10.1542/peds.2012-0225
Engström, P., Bartonek, Å., Tedroff, K., Orefelt, C., Haglund-Åkerlind, Y., & Gutierrez-Farewik, E. M. (2013). Botulinum toxin A does not improve the results of cast treatment for idiopathic toe-walking: A randomized controlled trial. The Journal of bone and joint surgery. American Volume, 95(5), 400–407. https://doi.org/10.2106/JBJS.L.00889
Engelbert, R., Gorter, J. W., Uiterwaal, C., van de Putte, E., & Helders, P. (2011). Idiopathic toe-walking in children, adolescents and young adults: A matter of local or generalised stiffness? BMC Musculoskeletal Disorders, 12, 61. https://doi.org/10.1186/1471-2474-12-61
Fleury, A., Kushki, A., Tanel, N., Anagnostou, E., & Chau, T. (2013). Statistical persistence and timing characteristics of repetitive circle drawing in children with ASD. Developmental Neurorehabilitation, 16(4), 245–254. https://doi.org/10.3109/17518423.2012.758184
Fournier, K. A., Kimberg, C. I., Radonovich, K. J., Tillman, M. D., Chow, J. W., Lewis, M. H., Bodfish, J. W., & Hass, C. J. (2010). Decreased static and dynamic postural control in children with autism spectrum disorders. Gait & Posture, 32(1), 6–9. https://doi.org/10.1016/j.gaitpost.2010.02.007
Fournier, K. A., Amano, S., Radonovich, K. J., Bleser, T. M., & Hass, C. J. (2014). Decreased dynamical complexity during quiet stance in children with autism spectrum disorders. Gait & Posture, 39(1), 420–423. https://doi.org/10.1016/j.gaitpost.2013.08.016
Gagnier, J. J., Kienle, G., Altman, D. G., Moher, D., Sox, H., Riley, D., & CARE Group* (2013). The CARE guidelines: Consensus-based clinical case reporting guideline development. Global advances in health and medicine, 2(5), 38–43. https://doi.org/10.7453/gahmj.2013.008
Green, D., Charman, T., Pickles, A., Chandler, S., Loucas, T., Simonoff, E., & Baird, G. (2009). Impairment in movement skills of children with autistic spectrum disorders. Developmental Medicine and Child Neurology, 51(4), 311–316. https://doi.org/10.1111/j.1469-8749.2008.03242.x
Harris, S. R. (2017). Early motor delays as diagnostic clues in autism spectrum disorder. European Journal of Pediatrics, 176(9), 1259–1262. https://doi.org/10.1007/s00431-017-2951-7
Herrin, K., & Geil, M. (2016). A comparison of orthoses in the treatment of idiopathic toe walking: A randomized controlled trial. Prosthetics and Orthotics International, 40(2), 262–269. https://doi.org/10.1177/0309364614564023
Hodges, A. C., Wilder, D. A., & Ertel, H. (2018). The use of multiple schedules to decrease toe walking in a child with autism. Behavioral Interventions, 33(4), 440–447. https://doi.org/10.1002/bin.1528
Hodges, A. C., Betz, A. M., Wilder, D. A., & Antia, K. (2019). The use of contingent acoustical feedback to decrease toe walking in a child with autism. Education and Treatment of Children, 42(2), 151–160. https://doi.org/10.1353/etc.2019.0007
Horsch, A., Götze, M., Geisbüsch, A., Beckmann, N., Tsitlakidis, S., Berrsche, G., & Klotz, M. (2019). Prevalence and classification of equinus foot in bilateral spastic cerebral palsy. World Journal of Pediatrics : WJP, 15(3), 276–280. https://doi.org/10.1007/s12519-019-00238-2
Hyde, S. A., FlŁytrup, I., Glent, S., Kroksmark, A. K., Salling, B., Steffensen, B. F., Werlauff, U., & Erlandsen, M. (2000). A randomized comparative study of two methods for controlling Tendo Achilles contracture in Duchenne muscular dystrophy. Neuromuscular Disorders: NMD, 10(4–5), 257–263. https://doi.org/10.1016/s0960-8966(99)00135-2
Kaur, M., M Srinivasan, S., & N Bhat, A. (2018). Comparing motor performance, praxis, coordination, and interpersonal synchrony between children with and without Autism Spectrum Disorder (ASD). Research in developmental disabilities, 72, 79–95. https://doi.org/10.1016/j.ridd.2017.10.025
Kohen-Raz, R., Volkmar, F. R., & Cohen, D. J. (1992). Postural control in children with autism. Journal of Autism and Developmental Disorders, 22(3), 419–432. https://doi.org/10.1007/BF01048244
Kratz SV (2020) Case report: Lymphatic drainage resolves toe walking gait in a boy with autism spectrum disorder gait in a boy with autism spectrum disorder. International Journal of Foot and Ankle, 4:039. https://doi.org/10.23937/2643-3885/1710039
Kushki, A., Chau, T., & Anagnostou, E. (2011). Handwriting difficulties in children with autism spectrum disorders: A scoping review. Journal of Autism and Developmental Disorders, 41(12), 1706–1716. https://doi.org/10.1007/s10803-011-1206-0
LeBarton, E. S., & Iverson, J. M. (2013). Fine motor skill predicts expressive language in infant siblings of children with autism. Developmental Science, 16(6), 815–827. https://doi.org/10.1111/desc.12069
Leyden, J., Fung, L., & Frick, S. (2019). Autism and toe-walking: Are they related? Trends and treatment patterns between 2005 and 2016. Journal of Children’s Orthopaedics, 13(4), 340–345. https://doi.org/10.1302/1863-2548.13.180160
Licari, M. K., Alvares, G. A., Varcin, K., Evans, K. L., Cleary, D., Reid, S. L., Glasson, E. J., Bebbington, K., Reynolds, J. E., Wray, J., & Whitehouse, A. (2020). Prevalence of motor difficulties in autism spectrum disorder: Analysis of a population-based cohort. Autism Research: Official Journal of the International Society for Autism Research, 13(2), 298–306. https://doi.org/10.1002/aur.2230
Lintanf, M., Bourseul, J. S., Houx, L., Lempereur, M., Brochard, S., & Pons, C. (2018). Effect of ankle-foot orthoses on gait, balance and gross motor function in children with cerebral palsy: A systematic review and meta-analysis. Clinical Rehabilitation, 32(9), 1175–1188. https://doi.org/10.1177/0269215518771824
Lloyd, M., MacDonald, M., & Lord, C. (2013). Motor skills of toddlers with autism spectrum disorders. Autism: the international journal of research and practice, 17(2), 133–146. https://doi.org/10.1177/1362361311402230
McPhillips, M., Finlay, J., Bejerot, S., & Hanley, M. (2014). Motor deficits in children with autism spectrum disorder: A cross-syndrome study. Autism Research: Official Journal of the International Society for Autism Research, 7(6), 664–676. https://doi.org/10.1002/aur.1408
MacDonald, M., Lord, C., & Ulrich, D. (2013). The relationship of motor skills and adaptive behavior skills in young children with autism spectrum disorders. Research in Autism Spectrum Disorders, 7(11), 1383–1390. https://doi.org/10.1016/j.rasd.2013.07.020
Maenner MJ, Shaw KA, Bakian AV, et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018. MMWR Surveill Summ. 2021;70(11):1–16. Published 2021 Dec 3. doi:https://doi.org/10.15585/mmwr.ss7011a1
Marcus, A., Sinnott, B., Bradley, S., & Grey, I. (2010). Treatment of idiopathic toe-walking in children with autism using GaitSpot auditory speakers and simplified habit reversal. Research in Autism Spectrum Disorders, 4(2), 260–267. https://doi.org/10.1016/j.rasd.2009.09.012
Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain & Development, 29(9), 565–570. https://doi.org/10.1016/j.braindev.2007.03.002
Murad, M. H., Sultan, S., Haffar, S., & Bazerbachi, F. (2018). Methodological quality and synthesis of case series and case reports. BMJ evidence-based medicine, 23(2), 60–63. https://doi.org/10.1136/bmjebm-2017-110853
Nobile, M., Perego, P., Piccinini, L., Mani, E., Rossi, A., Bellina, M., & Molteni, M. (2011). Further evidence of complex motor dysfunction in drug naive children with autism using automatic motion analysis of gait. Autism: the international journal of research and practice, 15(3), 263–283. https://doi.org/10.1177/1362361309356929
Ohara, R., Kanejima, Y., Kitamura, M., Izawa, P., & Kazuhiro. (2020). Association between social skills and motor skills in individuals with autism spectrum disorder: A systematic review. European Journal of Investigation in Health, Psychology and Education., 10(1), 276–296. https://doi.org/10.3390/ejihpe10010022
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, n71. https://doi.org/10.1136/bmj.n71
Pendharkar, G., Lai, D. T., & Begg, R. K. (2008). Detecting idiopathic toe-walking gait pattern from normal gait pattern using heel accelerometry data and Support Vector Machines. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2008, 4920–4923. https://doi.org/10.1109/IEMBS.2008.4650317
Perin, C., Valagussa, G., Mazzucchelli, M., Gariboldi, V., Cerri, C. G., Meroni, R., Grossi, E., Cornaggia, C. M., Menant, J., & Piscitelli, D. (2020). Physiological profile assessment of posture in children and adolescents with autism spectrum disorder and typically developing peers. Brain Sciences, 10(10), 681. https://doi.org/10.3390/brainsci10100681
Persicke, A., Jackson, M., & Adams, A. N. (2014). Brief report: An evaluation of TAGteach® components to decrease toe-walking in a 4-year-old child with autism. Journal of Autism and Developmental Disorders, 44(4), 965–968. https://doi.org/10.1007/s10803-013-1934-4
Piscitelli D, Ferrarello F, Ugolini A, Verola S, Pellicciari L. Measurement properties of the Gross Motor Function Classification System, Gross Motor Function Classification System-Expanded & Revised, Manual Ability Classification System, and Communication Function Classification System in cerebral palsy: A systematic review with meta-analysis. Developmental Medicine & Child Neurology. 2021 May 24. https://doi.org/10.1111/dmcn.14910
Robert, M. (2011). Toe walking in childhood. Prospective study of 130 toe walking children among which 19 affected of disorders of the autism spectrum [La démarche en équin chez l'enfant. Étude prospective de 130 enfants marchant en équin dont 19 atteints de troubles du spectre autistique]. Revue de Chirurgie Orthopedique et Traumatologique, 97S, S62—S66 https://doi.org/10.1016/j.rcot.2011.03.034
Rinehart, N. J., Tonge, B. J., Bradshaw, J. L., Iansek, R., Enticott, P. G., & McGinley, J. (2006). Gait function in high-functioning autism and Asperger’s disorder : Evidence for basal-ganglia and cerebellar involvement? European Child & Adolescent Psychiatry, 15(5), 256–264. https://doi.org/10.1007/s00787-006-0530-y
Rose, K. J., Burns, J., Wheeler, D. M., & North, K. N. (2010). Interventions for increasing ankle range of motion in patients with neuromuscular disease. The Cochrane database of systematic reviews, (2), CD006973. https://doi.org/10.1002/14651858.CD006973.pub2
Rutz, E., McCarthy, J., Shore, B. J., Shrader, M. W., Veerkamp, M., Chambers, H., Davids, J. R., Kay, R. M., Narayanan, U., Novacheck, T. F., Pierz, K., Rhodes, J., Shilt, J., Theologis, T., Van Campenhout, A., Dreher, T., & Graham, K. (2020). Indications for gastrocsoleus lengthening in ambulatory children with cerebral palsy: A Delphi consensus study. Journal of Children’s Orthopaedics, 14(5), 405–414. https://doi.org/10.1302/1863-2548.14.200145
Sätilä, H., Beilmann, A., Olsén, P., Helander, H., Eskelinen, M., & Huhtala, H. (2016). Does botulinum toxin A treatment enhance the walking pattern in idiopathic toe-walking? Neuropediatrics, 47(3), 162–168. https://doi.org/10.1055/s-0036-1582138
Shaw, T., & Soto-Garcia, M. (2021). Chiropractic management of toe-walking in an eight-year-old male diagnosed with autism spectrum disorder utilizing a functional approach: A case study. Journal of Bodywork and Movement Therapies, 26, 538–541. https://doi.org/10.1016/j.jbmt.2021.03.014
Shetreat-Klein, M., Shinnar, S., & Rapin, I. (2014). Abnormalities of joint mobility and gait in children with autism spectrum disorders. Brain & Development, 36(2), 91–96. https://doi.org/10.1016/j.braindev.2012.02.005
TAGteach International (2012). Retrieved August 17, 2021, from http://www.tagteach.com.
Valagussa, G., Trentin, L., Balatti, V., & Grossi, E. (2017). Assessment of presentation patterns, clinical severity, and sensorial mechanism of tip-toe behavior in severe ASD subjects with intellectual disability: A cohort observational study. Autism Research : Official Journal of the International Society for Autism Research, 10(9), 1547–1557. https://doi.org/10.1002/aur.1796
Valagussa, G., Trentin, L., Signori, A., & Grossi, E. (2018). Toe walking assessment in autism spectrum disorder subjects: A systematic review. Autism Research : Official Journal of the International Society for Autism Research, 11(10), 1404–1415. https://doi.org/10.1002/aur.2009
Valagussa, G., Balatti, V., Trentin, L., Piscitelli, D., Yamagata, M., & Grossi, E. (2020). Relationship between tip-toe behavior and soleus - gastrocnemius muscle lengths in individuals with autism spectrum disorders. Journal of Orthopaedics, 21, 444–448. https://doi.org/10.1016/j.jor.2020.08.013
Weber, D. (1978). “Toe-walking” in children with early childhood autism. Acta Paedopsychiatrica: International Journal of Child & Adolescent Psychiatry, 43(2–3), 73–83.
Wilder, D. A., Ertel, H., Hodges, A. C., Thomas, R., & Luong, N. (2020). The use of auditory feedback and edible reinforcement to decrease toe walking among children with autism. Journal of Applied Behavior Analysis, 53(1), 554–562. https://doi.org/10.1002/jaba.607
Wren, T. A., Cheatwood, A. P., Rethlefsen, S. A., Hara, R., Perez, F. J., & Kay, R. M. (2010). Achilles tendon length and medial gastrocnemius architecture in children with cerebral palsy and equinus gait. Journal of Pediatric Orthopedics, 30(5), 479–484. https://doi.org/10.1097/BPO.0b013e3181e00c80
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GV, DP, SB, and VP contributed to the idea for the review and to developing initial search procedures. SB performed the literature search and data analysis with secondary coding being completed by VP. GV and DP performed the qualitative evaluation of the included studies. GV wrote the initial draft of the manuscript with preparation and editing completed by DP, SB, VP, and LP. CMC, CP, MM, and EG assisted in revising and improving the manuscript. All authors read and approved the final manuscript.
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Valagussa, G., Piscitelli, D., Baruffini, S. et al. Little Evidence for Conservative Toe Walking Interventions in Autism Spectrum Disorders: a Systematic Review. Rev J Autism Dev Disord 11, 107–120 (2024). https://doi.org/10.1007/s40489-022-00329-3
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DOI: https://doi.org/10.1007/s40489-022-00329-3