Abstract
Purpose of Review
Frailty is an emerging concept in liver transplantation. We reviewed the literature for the tests of frailty which have been validated to predict outcomes in patients with cirrhosis evaluated for liver transplantation.
Recent Findings
Several tools have been developed to further stratify risk of adverse events independent of liver disease severity. These include tests of disability such as activities of daily living and the Karnofsky Performance Score, as well as tests of physical frailty, such as the Liver Frailty Index (handgrip, chair stands, and balance).
Summary
Increasingly, the frailty assessment is seen as a critical component of the liver transplant evaluation. Further research is needed to clarify the optimal timing of testing and the implications of longitudinal change.
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Funding
Elliot Tapper receives funding from the National Institutes of Health through the Michigan Institute for Clinical and Health Research (KL2TR002241).
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Elliot Tapper reports grants from Valeant and Gilead and personal fees from Novartis for a fatty liver disease study.
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Elliot Tapper is the guarantor of this article.
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This article is part of the Topical Collection on Frailty and Gerontology
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Tapper, E.B. Frailty and Outcomes After Liver Transplantation. Curr Transpl Rep 6, 1–6 (2019). https://doi.org/10.1007/s40472-019-0222-4
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DOI: https://doi.org/10.1007/s40472-019-0222-4