Skip to main content

Advertisement

Log in

The Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes

  • Opioids (A Konova and S Yip, Section Editor)
  • Published:
Current Addiction Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Chronic pain among individuals diagnosed with opioid use disorder (OUD) receiving opioid agonist treatment (OAT) is common. We review extant literature on the impact of chronic pain on OAT outcomes (i.e., illicit opioid use and OAT retention).

Recent Findings

We found 13 manuscripts using 9 datasets. The relationship between chronic pain and OAT outcomes is mixed. Most studies reported no relationship between chronic pain and illicit opioid use, but definitions of chronic pain were inconsistent. There was some evidence that chronic pain is associated with higher likelihood of drug use, and associations with retention were rarely reported.

Summary

OAT clinics should thoughtfully assess pain at intake and regularly assess pain intensity and interference. Repeated assessments during daily life offer some advantages, and there is a need for nonpharmacologic pain treatments that complement OAT clinical care. These may require additional resources for OAT clinics to effectively address pain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Medications for opioid use disorder saves lives. In: National Academies of Sciences E, and Medicine, editor. Washington, DC: The National Academies Press; 2019. This important document summarizes the wealth of clinical evidence on medications for OUD (such as bupernorphine and methadone) that establishes medications for OUD as the standard of care for OUD.

  2. Mattick RP, Breen C, Kimber J, Davoli M. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Syst Rev. 2009(3):Cd002209. https://doi.org/10.1002/14651858.CD002209.pub2.

  3. Mattick RP, Breen C, Kimber J, Davoli M. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev. 2014(2):Cd002207. https://doi.org/10.1002/14651858.CD002207.pub4.

  4. •• O’Connor AM, Cousins G, Durand L, Barry J, Boland F. Retention of patients in opioid substitution treatment: a systematic review. PLoS One. 2020;15(5):e0232086. https://doi.org/10.1371/journal.pone.0232086This review summarizes retention in OAT across mutliple studies and highlights the need for a consensus definition of retention in order to better evaluate OUD outcomes.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Collins FS, Koroshetz WJ, Volkow ND. Helping to end addiction over the long-term: the research plan for the NIH HEAL initiative. JAMA. 2018;320(2):129–30. https://doi.org/10.1001/jama.2018.8826.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Rosenblum A, Parrino M, Schnoll SH, Fong C, Maxwell C, Cleland CM, et al. Prescription opioid abuse among enrollees into methadone maintenance treatment. Drug Alcohol Depend. 2007;90(1):64–71. https://doi.org/10.1016/j.drugalcdep.2007.02.012.

    Article  PubMed  Google Scholar 

  7. •• Hser YI, Mooney LJ, Saxon AJ, Miotto K, Bell DS, Huang D. Chronic pain among patients with opioid use disorder: results from electronic health records data. J Subst Abus Treat. 2017;77:26–30. https://doi.org/10.1016/j.jsat.2017.03.006This important manuscript uses electronic health records of US adults from 2006-2015 to evaluate diagnostic precedence of OUD and chronic pain.

    Article  Google Scholar 

  8. Barry DT, Beitel M, Joshi D, Schottenfeld RS. Pain and substance-related pain-reduction behaviors among opioid dependent individuals seeking methadone maintenance treatment. Am J Addict. 2009;18(2):117–21. https://doi.org/10.1080/10550490902772470.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Barry DT, Savant JD, Beitel M, Cutter CJ, Moore BA, Schottenfeld RS, et al. Pain and associated substance use among opioid dependent individuals seeking office-based treatment with buprenorphine-naloxone: a needs assessment study. Am J Addict. 2013;22(3):212–7. https://doi.org/10.1111/j.1521-0391.2012.00327.x.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Tsui JI, Lira MC, Cheng DM, Winter MR, Alford DP, Liebschutz JM, et al. Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy. Drug Alcohol Depend. 2016;166:26–31. https://doi.org/10.1016/j.drugalcdep.2016.06.024.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. Jama. 2003;289(18):2370–8. https://doi.org/10.1001/jama.289.18.2370.

    Article  PubMed  Google Scholar 

  12. Griffin ML, McDermott KA, McHugh RK, Fitzmaurice GM, Jamison RN, Weiss RD. Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain. Drug Alcohol Depend. 2016;163:216–21. https://doi.org/10.1016/j.drugalcdep.2016.04.023.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bicket M, Park J, Torrie A, Allen S, Weir B, Sherman S. Factors associated with chronic pain and non-medical opioid use among people who inject drugs. Addict Behav. 2019. https://doi.org/10.1016/j.addbeh.2019.106172.

  14. Dahlman D, Kral AH, Wenger L, Hakansson A, Novak SP. Physical pain is common and associated with nonmedical prescription opioid use among people who inject drugs. Subst Abuse Treat Prev Policy. 2017;12(1):29. https://doi.org/10.1186/s13011-017-0112-7.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bennett AS, Watford JA, Elliott L, Wolfson-Stofko B, Guarino H. Military veterans’ overdose risk behavior: demographic and biopsychosocial influences. Addict Behav. 2019;99:106036. https://doi.org/10.1016/j.addbeh.2019.106036.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Hay JL, White JM, Bochner F, Somogyi AA, Semple TJ, Rounsefell B. Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients. J Pain. 2009;10(3):316–22. https://doi.org/10.1016/j.jpain.2008.10.003.

    Article  CAS  PubMed  Google Scholar 

  17. Wachholtz A, Gonzalez G. Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain. Drug Alcohol Depend. 2014;145:143–9. https://doi.org/10.1016/j.drugalcdep.2014.10.010.

    Article  PubMed  PubMed Central  Google Scholar 

  18. •• Biondi BE, Zheng X, Frank CA, Petrakis I, Springer SA. A literature review examining primary outcomes of medication treatment studies for opioid use disorder: what outcome should be used to measure opioid treatment success? Am J Addict. 2020;29(4):249–67. https://doi.org/10.1111/ajad.13051This literature review provides a comprehensive overivew of OUD outcomes and advocates for standardized treatment outcomes for medications for OUD that will inform research and clinical practice.

    Article  PubMed  Google Scholar 

  19. Peles E, Schreiber S, Gordon J, Adelson M. Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. Pain. 2005;113(3):340–6. https://doi.org/10.1016/j.pain.2004.11.011.

    Article  CAS  PubMed  Google Scholar 

  20. Barry DT, Beitel M, Garney B, Joshi D, Rosenblum A, Schottenfeld RS. Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. J Clin Psychiatry. 2009;70(9). https://doi.org/10.4088/JCP.08 m04367.

  21. Higgins C, Smith BH, Matthews K. Substance misuse in patients who have comorbid chronic pain in a clinical population receiving methadone maintenance therapy for the treatment of opioid dependence. Drug Alcohol Depend. 2018;193:131–6. https://doi.org/10.1016/j.drugalcdep.2018.08.038.

    Article  PubMed  Google Scholar 

  22. Stevenson E, Cole J. Associations between chronic non-cancer pain and medication assisted treatment outcomes for opiate addiction. Am J Addict. 2015;24(2). https://doi.org/10.1111/ajad.12151.

  23. Weiss RD, Sharpe Potter J, Provost SE, Huang Z, Jacobs P, et al. A multi-site, two-phase, prescription opioid addiction treatment study (POATS): rationale, design, and methodology. Contemp Clin Trials. 2010;31(2). https://doi.org/10.1016/j.cct.2010.01.003.

  24. Weiss RD, Potter JS, Fiellin DA, Byrne M, Connery HS, Dickinson W, et al. Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: a 2-phase randomized controlled trial. Arch Gen Psychiatry. 2011;68(12):1238–46. https://doi.org/10.1001/archgenpsychiatry.2011.121.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. McDermott K, Griffin M, McHugh R, Fitzmaurice G, Jamison R, Provost S, et al. Long-term naturalistic follow-up of chronic pain in adults with prescription opioid use disorder. Drug Alcohol Depend. 2019. https://doi.org/10.1016/j.drugalcdep.2019.107675.

  26. Worley MJ, Heinzerling KG, Shoptaw S, Ling W. Volatility and change in chronic pain severity predict outcomes of treatment for prescription opioid addiction. Addiction. 2017;112(7):1202–9. https://doi.org/10.1111/add.13782.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Messina BG, Worley MJ. Effects of craving on opioid use are attenuated after pain coping counseling in adults with chronic pain and prescription opioid addiction. J Consult Clin Psychol. 2019;87(10). https://doi.org/10.1037/ccp0000399.

  28. Olsen Y, Sharfstein JM. Confronting the stigma of opioid use disorder--and its treatment. Jama. 2014;311(14):1393–4. https://doi.org/10.1001/jama.2014.2147.

    Article  CAS  PubMed  Google Scholar 

  29. Trafton JA, Oliva EM, Horst DA, Minkel JD, Humphreys K. Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment. Drug Alcohol Depend. 2004;73(1):23–31.

    Article  Google Scholar 

  30. Committee NPMC. Pain as the 5th vital sign toolkit, revised edition. In: Administration VH, editor. Washington. 2000.

  31. Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manag. 2011;41(6):1073–93. https://doi.org/10.1016/j.jpainsymman.2010.08.016.

    Article  Google Scholar 

  32. • Karcioglu O, Topacoglu H, Dikme O. A systematic review of the pain scales in adults: which to use? Am J Emerg Med. 2018;36(4):707–14. https://doi.org/10.1016/j.ajem.2018.01.008This systematic review highlights the utility of brief subjective assessments of pain. Although these measures were deemed to be valid and reliabile, assessing just pain intensity is the minimum necessary to evaluate treatment options.

    Article  PubMed  Google Scholar 

  33. Krebs EE, Lorenz KA, Bair MJ, Damush TM, Wu J, Sutherland JM, et al. Development and initial validation of the PEG, a three-item scale assessing pain intensity and interference. J Gen Intern Med. 2009;24(6):733–8. https://doi.org/10.1007/s11606-009-0981-1.

    Article  PubMed  PubMed Central  Google Scholar 

  34. •• May M, Junghaenel DU, Ono M, Stone AA, Schneider S. Ecological momentary assessment methodology in chronic pain research: a systematic review. J Pain. 2018. https://doi.org/10.1016/j.jpain.2018.01.006This important systematic review provides a comprehensive examination of using EMA to assess pain, primarily in chronic pain patients. The authors also provide helpful recommendations with respect to the method and time window of assessment.

  35. Mun CJ, Suk HW, Davis MC, Karoly P, Finan P, Tennen H, et al. Investigating intraindividual pain variability: methods, applications, issues, and directions. Pain. 2019. https://doi.org/10.1097/j.pain.0000000000001626.

  36. Kucyi A, Davis KD. The dynamic pain connectome. Trends Neurosci. 2015;38(2):86–95. https://doi.org/10.1016/j.tins.2014.11.006.

    Article  CAS  PubMed  Google Scholar 

  37. Peolsson M, Hyden LC, Satterlund Larsson U. Living with chronic pain: a dynamic learning process. Scand J Occup Ther. 2000;7:114–25.

    Article  Google Scholar 

  38. Zautra A, Smith B, Affleck G, Tennen H. Examinations of chronic pain and affect relationships: applications of a dynamic model of affect. J Consult Clin Psychol. 2001;69(5):786–95.

    Article  CAS  Google Scholar 

  39. Schneider S, Junghaenel DU, Keefe FJ, Schwartz JE, Stone AA, Broderick JE. Individual differences in the day-to-day variability of pain, fatigue, and well-being in patients with rheumatic disease: associations with psychological variables. Pain. 2012;153(4):813–22. https://doi.org/10.1016/j.pain.2012.01.001.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Shiffman S, Stone AA, Hufford MR. Ecological momentary assessment. Annu Rev Clin Psychol. 2008;4:1–32.

    Article  Google Scholar 

  41. Heapy A, Dziura J, Buta E, Goulet J, Kulas JF, Kerns RD. Using multiple daily pain ratings to improve reliability and assay sensitivity: how many is enough? J Pain. 2014;15(12):1360–5. https://doi.org/10.1016/j.jpain.2014.09.012.

    Article  PubMed  Google Scholar 

  42. Worley MJ, Heinzerling KG, Shoptaw S, Ling W. Pain volatility and prescription opioid addiction treatment outcomes in patients with chronic pain. Exp Clin Psychopharmacol. 2015;23(6):428–35. https://doi.org/10.1037/pha0000039.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. • Carpenter RW, Lane SP, Bruehl S, Trull TJ. Concurrent and lagged associations of prescription opioid use with pain and negative affect in the daily lives of chronic pain patients. J Consult Clin Psychol. 2019;87(10):872–86. https://doi.org/10.1037/ccp0000402This study uses EMA to evaluate negative affect and pain in a chronic pain sample. The results highlight dymanic relationships between pain and negative affect and predictors and consequences of opioid use in individuals at risk for OUD.

    Article  PubMed  PubMed Central  Google Scholar 

  44. • MacLean RR, Armstrong JL, Sofuoglu M. Stress and opioid use disorder: a systematic review. Addict Behav. 2019;98:106010. https://doi.org/10.1016/j.addbeh.2019.05.034This systematic review highlights high levels of reported stress in individuals with OUD and the absence of evidence based nonpharmacologic treatment for increased stress in individuals with OUD.

    Article  PubMed  Google Scholar 

  45. •• Panlilio LV, Stull SW, Kowalczyk WJ, Phillips KA, Schroeder JR, Bertz JW, et al. Stress, craving and mood as predictors of early dropout from opioid agonist therapy. Drug Alcohol Depend. 2019;202:200–8. https://doi.org/10.1016/j.drugalcdep.2019.05.026This important manuscript uses EMA to evaluate predictors of OAT dropout. Results did not evaluate pain, but dynamic variables strongly linked to the experience of pain were associated with increased OAT dropout.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Butler SF, Fernandez K, Benoit C, Budman SH, Jamison RN. Validation of the revised screener and opioid assessment for patients with pain (SOAPP-R). J Pain. 2008;9(4):360–72. https://doi.org/10.1016/j.jpain.2007.11.014.

    Article  PubMed  PubMed Central  Google Scholar 

  47. •• MacLean R, Spinola S, Manhapra A, Sofuoglu M. Systematic review of pain severity and opioid craving in chronic pain and opioid use disorder. Pain Med. 2020. https://doi.org/10.1093/pm/pnz228This important systematic review examined existing literature on pain intensity and opioid craving in individuals with OUD and/or chronic pain. Results demonstrated considerably heterogeniety in assessment of both pain and opioid craving.

  48. Fareed A, Vayalapalli S, Casarella J, Amar R, Drexler K. Heroin anticraving medications: a systematic review. Am J Drug Alcohol Abuse. 2010;36(6):332–41. https://doi.org/10.3109/00952990.2010.505991.

    Article  PubMed  Google Scholar 

  49. Fareed A, Vayalapalli S, Stout S, Casarella J, Drexler K, Bailey SP. Effect of methadone maintenance treatment on heroin craving, a literature review. J Addict Dis. 2011;30(1):27–38. https://doi.org/10.1080/10550887.2010.531672.

    Article  PubMed  Google Scholar 

  50. •• Kleykamp B, De Santis M, Dworkin R, Huhn A, Kampman K, Montoya I, et al. Craving and opioid use disorder: a scoping review. Drug Alcohol Depend. 2019;205:107639. https://doi.org/10.1016/j.drugalcdep.2019.107639This important review evaluated opioid craving instruments in the literature and reported that craving assessments varied considerably in format, timeframe, and factor structure.

    Article  CAS  PubMed  Google Scholar 

  51. Ashrafioun L. Prescription opioid craving: relationship with pain and substance use-related characteristics. Subst Use Misuse. 2016;51(11):1512–20. https://doi.org/10.1080/10826084.2016.1188948.

    Article  PubMed  Google Scholar 

  52. Mc Hugh RK, Fitzmaurice GM, Carroll KM, Griffin ML, Hill KP, Wasan AD, et al. Assessing craving and its relationship to subsequent prescription opioid use among treatment-seeking prescription opioid dependent patients. Drug Alcohol Depend. 2014;145:121–6. https://doi.org/10.1016/j.drugalcdep.2014.10.002.

    Article  Google Scholar 

  53. • Darnall B. To treat pain, study people in all their complexity. Nature. 2018;557(7703):7. https://doi.org/10.1038/d41586-018-04994-5This commentary acknowledges the complexity of treating chronic pain and advocates a multimodal approach to develop new treatments for chronic pain.

    Article  CAS  PubMed  Google Scholar 

  54. Berg KM, Arnsten JH, Sacajiu G, Karasz A. Providers’ experiences treating chronic pain among opioid-dependent drug users. J Gen Intern Med. 2009;24(4):482–8. https://doi.org/10.1007/s11606-009-0908-x.

    Article  PubMed  PubMed Central  Google Scholar 

  55. •• Henningfield JE, Ashworth JB, Gerlach KK, Simone B, Schnoll SH. The nexus of opioids, pain, and addiction: challenges and solutions. Prev Med. 2019;128:105852. https://doi.org/10.1016/j.ypmed.2019.105852This important article briefly reviews the historical context of the opioid epidemic and advocates for evidence-based treatments and policies to guide clinical recommendations and increase access to appropriate care.

    Article  PubMed  Google Scholar 

  56. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain--United States, 2016. Jama. 2016;315(15):1624–45. https://doi.org/10.1001/jama.2016.1464.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. VA/DoD clinical practice guideline for opioid therapy for chronic pain. In: Affairs DoV, editor.2017.

  58. Dunn KE, Finan PH, Tompkins DA, Fingerhood M, Strain EC. Characterizing pain and associated coping strategies in methadone and buprenorphine-maintained patients. Drug Alcohol Depend. 2015;157:143–9. https://doi.org/10.1016/j.drugalcdep.2015.10.018.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Barry DT, Savant JD, Beitel M, Cutter CJ, Schottenfeld RS, Kerns RD, et al. The feasibility and acceptability of groups for pain management in methadone maintenance treatment. J Addict Med. 2014;8(5):338–44. https://doi.org/10.1097/adm.0000000000000055.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. •• Barry DT, Beitel M, Cutter CJ, Fiellin DA, Kerns RD, Moore BA, et al. An evaluation of the feasibility, acceptability, and preliminary efficacy of cognitive-behavioral therapy for opioid use disorder and chronic pain. Drug Alcohol Depend. 2019;194:460–7. https://doi.org/10.1016/j.drugalcdep.2018.10.015This important study is among the first to attempt to integrate CBT for chronic pain and OUD in individuals with OUD engaged in OAT. Results demonstrated that integrating CBT within OAT clinical care was feasible and acceptable with the potential to improve chronic pain in individuals with OUD.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Ross MacLean.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Dr. MacLean has been supported by the Department of VA New England Mental Illness Research, Education, and Clinical Center (MIRECC) and VA Connecticut Healthcare System. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

MacLean, R.R., Spinola, S., Garcia-Vassallo, G. et al. The Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes. Curr Addict Rep 8, 100–108 (2021). https://doi.org/10.1007/s40429-020-00352-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40429-020-00352-6

Keywords

Navigation