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Integrase strand transfer inhibitors can simplify HIV treatment

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Abstract

Integrase strand transfer inhibitors (INSTIs) bictegravir, dolutegravir, cabotegravir, elvitegravir and raltegravir, mostly available as fixed dose combinations are recommended treatments in both newly diagnosed and treatment-experienced patients with HIV. Their efficacy, good tolerability and simplified dosing regimens facilitate treatment adherence and a recently approved cabotegravir 4-weekly injection is a major advance.

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    Caroline Fenton, Arnold Lee & Zaina T. Al-Salama

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C. Fenton, a contracted employee of Adis International Ltd/Springer Nature, and A. Lee, a salaried employee of Adis International Ltd/Springer Nature, declare no relevant conflicts of interest. Z.T. Al-Salama is a salaried employee of Adis International/ Springer Nature, is an editor of Drugs & Therapy Perspectives, was not involved in any publishing decision for the manuscript, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.

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Fenton, C., Lee, A. & Al-Salama, Z.T. Integrase strand transfer inhibitors can simplify HIV treatment. Drugs Ther Perspect 37, 300–312 (2021). https://doi.org/10.1007/s40267-021-00847-w

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