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Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles

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Chemical Research in Chinese Universities Aims and scope

Abstract

Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues. To promote the antibacterial and sealing effects of a root canal filling, core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer, zinc oxide-eugenol(ZOE). The obtained CaO/ZnO particles had a size of 80–90 nm and a core-shell structure. The film thickness, flow rate, pH, and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested. The pH and calcium ion release results showed a slight increase in the prepared nanospheres, with a flow rate of 24.22 mm and a formed film thickness of 30 µm, which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials). Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05). A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nanospheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05). The core-shell structured CaO/ZnO nanosphere paste displayed excellent sealing and antibacterial properties, and it has promising application potential in endodontics.

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Authors and Affiliations

  1. School of Stomatology, Jilin University, Changchun, 130021, P. R. China

    Lili Wang, Yanan Liu, Huimin Liu, Hongchen Sun & Xiangwei Li

  2. Hospital Attached to Changchun University of Chinese Medicine, Changchun, 130041, P. R. China

    Xiaoxing Peng

  3. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, P. R. China

    Yuanqing Sun, Quan Lin & Bai Yang

  4. Department of Biomedical Sciences, Texas A&M University, College of Dentistry, Dallas, TX, 75246, USA

    Xiaohua Liu

Authors
  1. Lili Wang
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  2. Yanan Liu
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  3. Xiaoxing Peng
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  4. Yuanqing Sun
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  5. Xiaohua Liu
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  6. Huimin Liu
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  7. Quan Lin
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  8. Hongchen Sun
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  9. Bai Yang
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  10. Xiangwei Li
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Corresponding author

Correspondence to Xiangwei Li.

Additional information

Supported by the Jilin Provincial Health Department Research Projects, China(No.2017J065) and the Jilin Provincial Education Department Research Projects, China(No.JJKH20180229KJ).

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Wang, L., Liu, Y., Peng, X. et al. Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles. Chem. Res. Chin. Univ. 36, 970–975 (2020). https://doi.org/10.1007/s40242-020-9029-1

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  • DOI: https://doi.org/10.1007/s40242-020-9029-1

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