Abstract
A facile and efficient method for the preparation of methyl ketones was developed in the reaction of alkynes and alkenes with PhIO-BF3∙Et2O. The reaction features mild conditions, short time and metal-free catalyst. The possible mechanism for the formation of methyl ketones was proposed. H2O functions as both a nucleophile and an oxygen source.
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Supported by the National Natural Science Foundation of China(No.21602111), the Natural Science Foundation of Jiangsu Province, China(No.BK20150832) and the Scientific Foundation of Nanjing University of Posts and Telecommunications, China (Nos.NUPTSF, NY215078).
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Wei, Y., Zheng, X. & Xie, X. PhIO-mediated Synthesis of Ketones from Alkynes and Alkenes. Chem. Res. Chin. Univ. 35, 26–32 (2019). https://doi.org/10.1007/s40242-019-8264-9
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DOI: https://doi.org/10.1007/s40242-019-8264-9