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Dissipative Particle Dynamics Study on Platycodin’s Solubilization Enhancing Effect Towards Five Drug Components

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Abstract

In this study, a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components. Two factors were mainly considered, including the XlogP value of drug components and the sugar chain length of platycodin. As a result, it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin, and it was different between the drug’s own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect.

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Authors and Affiliations

  1. Traditional Chinese Medicine Institute, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China

    Zhimin Wu, Haiou Ding, Chang Yang, Shujuan Guo, Xingxing Dai & Xinyuan Shi

  2. Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing, 100029, P. R. China

    Zhimin Wu, Haiou Ding, Xingxing Dai & Xinyuan Shi

Authors
  1. Zhimin Wu
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  2. Haiou Ding
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  3. Chang Yang
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  4. Shujuan Guo
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  5. Xingxing Dai
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  6. Xinyuan Shi
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Corresponding author

Correspondence to Xinyuan Shi.

Additional information

Supported by the Natural Science Foundation of Beijing, China(No.7162122).

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Wu, Z., Ding, H., Yang, C. et al. Dissipative Particle Dynamics Study on Platycodin’s Solubilization Enhancing Effect Towards Five Drug Components. Chem. Res. Chin. Univ. 35, 65–70 (2019). https://doi.org/10.1007/s40242-018-8250-7

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  • DOI: https://doi.org/10.1007/s40242-018-8250-7

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