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pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery

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Chemical Research in Chinese Universities Aims and scope

Abstract

A smart polycarbonate(PCA) copolymer-based nanoparticle(NanoPCA) with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functional PCA-based copolymers including poly(2-amino-1,3-propanediol carbonate-co-L-lactide)[P(CA-co-LA)], poly(2-amino-1,3-propanediol carbonate-co-L-lactide)-g-methoxy-poly(ethylene glycol)[P(CA-co-LA)-g-MPEG], and poly(2-amino-1,3-propanediol carbonate-co-L-lactide)-g-poly(ethylene glycol)-cyclic(Arg-Gly-Asp-D-Phe-Lys) [P(CA-co-LA)-g-PEG-cRGD] for targeted anticancer drug delivery. pH-Responsive studies demonstrated that the loading doxorubicin(DOX) released faster from NanoPCA at acidic conditions due to protonation effects of P(CA-co-LA) copolymers. Furthermore, the in vitro and in vivo investigations demonstrate that the DOX-loaded NanoPCA exhibited significant tumor targeting ability, outstanding antitumor effect and excellent biological safety in the treatment of oral squamous cell carcinoma(OSCC). Therefore, this work provides a promising drug delivery platform for cancer therapy and other applications.

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Authors and Affiliations

  1. Department of Stomatology, the General Hospital of Chinese PLA, Beijing, 100853, P. R. China

    Yunxia Li, Zhiguang Fu, Huanhuan Wang & Ning Wen

  2. Department of Oncology, the General Hospital of Chinese PLA, Beijing, 100853, P. R. China

    Wenjuan Du

  3. College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China

    Jiexin Wang, Yuan Le & Jianjun Zhang

Authors
  1. Yunxia Li
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  2. Wenjuan Du
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  3. Zhiguang Fu
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  4. Huanhuan Wang
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  5. Jiexin Wang
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  6. Yuan Le
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  7. Jianjun Zhang
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  8. Ning Wen
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Corresponding authors

Correspondence to Jianjun Zhang or Ning Wen.

Additional information

Supported by the National High Technolgy Researeh and Development Program of China(No.2013AA032201), the National Natural Science Foundation of China(Nos.81703003, 51303009, 21476018, 21622601) and the National Key R&D Program of China(No.2015CB932101).

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Li, Y., Du, W., Fu, Z. et al. pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery. Chem. Res. Chin. Univ. 34, 1041–1050 (2018). https://doi.org/10.1007/s40242-018-8147-5

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  • DOI: https://doi.org/10.1007/s40242-018-8147-5

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