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Evaluation of pollutants in perfumes, colognes and health effects on the consumer: a systematic review

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Abstract

Cosmetic products, especially perfumes and colognes, are widely used in various communities. However, the use of these products can have side effects on consumers. This article aims to review the relevant literature published up to August 2020 to determine whether perfumes and colognes can affect people’s health. Relevant articles were identified through electronic search. A total of 562 articles were selected and finally 37 related articles were included in the study after the screening process. The results of this systematic study showed that phthalates, aldehydes, parabens and aluminum-based salts are the most important contaminants in aromatic products that cause side effects such as allergies, breast cancer, reproductive disorders, especially in males, skin allergies, nervous system damage and migraine headaches for consumers. The incidence of complications in people using these products depends on parameters such as age, gender, race, amount of substance consumed, duration of use and economic status, and regarding the relationship between diseases such as cancer, respiratory disorders and endocrine with common contaminants in aromatic products, incidence of these diseases is probable in consumers which require further research to prove.

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Abbreviations

PP:

propyl paraben.

BP:

butyl paraben.

PE:

Phthalate ester.

FDA:

Food and Drug Administration.

VOC:

Volatile organic compound.

CACD:

cosmetic allergic contact dermatitis.

EDC:

endocrine disrupting chemical.

PCP:

personal care product.

UOQ:

upper outer quadrant.

References

  1. Chisvert A, et al. Perfumes in cosmetics: regulatory aspects and analytical methods. In: Analysis of cosmetic products: Elsevier; 2018. p. 225–48.

    Chapter  Google Scholar 

  2. Abedi G, Talebpour Z, Jamechenarboo F. The survey of analytical methods for sample preparation and analysis of fragrances in cosmetics and personal care products. TrAC Trends Anal Chem. 2018;102:41–59.

    Article  CAS  Google Scholar 

  3. Steinemann A. Exposures and effects from fragranced consumer products in Sweden. Air Quality, Atmosphere & Health. 2018;11(5):485–91.

    Article  CAS  Google Scholar 

  4. Pérez-Fernández V, et al. Separation of phthalates by cyclodextrin modified micellar electrokinetic chromatography: quantitation in perfumes. Anal Chim Acta. 2013;782:67–74.

    Article  CAS  Google Scholar 

  5. Lee SD, Analyzing Specific Health Hazards in Perfumes by Identifying Ingredients using Gas Chromatography-Mass Spectrometry.

  6. Orecchio S, Indelicato R, Barreca S. Determination of selected phthalates by gas chromatography–mass spectrometry in personal perfumes. J Toxic Environ Health A. 2015;78(15):1008–18.

    Article  CAS  Google Scholar 

  7. Duty SM, et al. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect. 2005;113(11):1530–5.

    Article  CAS  Google Scholar 

  8. Patel S. Fragrance compounds: the wolves in sheep’s clothings. Med Hypotheses. 2017;102:106–11.

    Article  CAS  Google Scholar 

  9. Berger KP, et al. Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study. J expos sci environ epidem. 2019;29(1):21–32.

    Article  CAS  Google Scholar 

  10. Chingin K, et al. Detection of diethyl phthalate in perfumes by extractive electrospray ionization mass spectrometry. Anal Chem. 2009;81(1):123–9.

    Article  CAS  Google Scholar 

  11. Sarma N, Ghosh S. Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children. Indian J Dermat, Vener, Leprol. 2010;76(1):38.

    Article  Google Scholar 

  12. Brandt K. Final report on the safety assessment of dibutyl phthalate, dimethyl phthalate, and diethyl phthalate. J Am Coll Toxicol. 1985;4:267–303.

    Article  Google Scholar 

  13. Uhde E, Schulz N. Impact of room fragrance products on indoor air quality. Atmos Environ. 2015;106:492–502.

    Article  CAS  Google Scholar 

  14. Api AM. Sensitization methodology and primary prevention of the research institute for fragrance materials. Dermatology. 2002;205(1):84–7.

    Article  Google Scholar 

  15. Darbre PD. Overview of air pollution and endocrine disorders. Internat J Gen Med. 2018;11:191.

    Article  CAS  Google Scholar 

  16. Pereira C, Mapuskar K, Rao CV. Chronic toxicity of diethyl phthalate—a three generation lactational and gestational exposure study on male Wistar rats. Environ Toxicol Pharmacol. 2007;23(3):319–27.

    Article  CAS  Google Scholar 

  17. Park M, et al. Relationship between personal care products usage and triclosan exposure: the second Korean National Environmental Health Survey (KoNEHS 2012–2014). Annals Occupat Environ Med. 2019;31(1):1–8.

    Article  Google Scholar 

  18. Rahman MM, Kim K-H. Potential hazard of volatile organic compounds contained in household spray products. Atmos Environ. 2014;85:266–74.

    Article  CAS  Google Scholar 

  19. Steinemann A. Health and societal effects from exposure to fragranced consumer products. Prev Med Rep. 2017;5:45–7.

    Article  Google Scholar 

  20. Steinemann A. Fragranced consumer products: sources of emissions, exposures, and health effects in the UK. Air Quality, Atmosphere & Health. 2018;11(3):253–8.

    Article  CAS  Google Scholar 

  21. Fromme H, et al. Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). Indoor Air. 2004;14(3):188–95.

    Article  CAS  Google Scholar 

  22. Lalko J, Isola D, Api A. Ethanol and diethyl phthalate: vehicle effects in the local lymph node assay. Int J Toxicol. 2004;23(3):171–7.

    Article  CAS  Google Scholar 

  23. Panel TRE, et al. A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients. Food Chem Toxicol. 2007;45(1):S318–61.

    Article  Google Scholar 

  24. Dodson RE, et al. Endocrine disruptors and asthma-associated chemicals in consumer products. Environ Health Perspect. 2012;120(7):935–43.

    Article  CAS  Google Scholar 

  25. Parlett LE, Calafat AM, Swan SH. Women’s exposure to phthalates in relation to use of personal care products. Journal of exposure science & environmental epidemiology. 2013;23(2):197–206.

    Article  CAS  Google Scholar 

  26. Romero-Franco M, et al. Personal care product use and urinary levels of phthalate metabolites in Mexican women. Environ Int. 2011;37(5):867–71.

    Article  CAS  Google Scholar 

  27. Larsson K, et al. Exposure determinants of phthalates, parabens, bisphenol a and triclosan in Swedish mothers and their children. Environ Int. 2014;73:323–33.

    Article  CAS  Google Scholar 

  28. Politano VT, et al. The effects of vehicles on the human dermal irritation potentials of allyl esters. Int J Toxicol. 2006;25(3):183–93.

    Article  CAS  Google Scholar 

  29. Gilpin SJ, Hui X, Maibach HI. Volatility of fragrance chemicals: patch testing implications. Dermatitis. 2009;20(4):200–7.

    Article  CAS  Google Scholar 

  30. Lim M, et al. Receptor-based aggregate exposure assessment of phthalates based on individual's simultaneous use of multiple cosmetic products. Food Chem Toxicol. 2019;127:163–72.

    Article  CAS  Google Scholar 

  31. Kim YY, et al. Nasal cannula-induced chemical depigmentation. Contact Dermatitis. 2006;55(2):113–4.

    Article  Google Scholar 

  32. Yourick, J.J. and R.L. Bronaugh. Percutaneous absorption and metabolism of coumarin in human and rat skin. In journal of applied toxicology: an international forum devoted to research and methods emphasizing direct clinical, industrial and environmental applications. 1997. Wiley Online Library.

  33. Bruze M, et al. Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral®) in the European baseline patch test series. Contact Derm. 2008;58(3):129–33.

    Article  CAS  Google Scholar 

  34. Mostafa A, Shaaban H. Development and validation of a dispersive liquid–liquid microextraction method for the determination of phthalate esters in perfumes using gas chromatography-mass spectrometry. RSC Adv. 2018;8(47):26897–905.

    Article  CAS  Google Scholar 

  35. Gilpin S, Hui X, Maibach H. In vitro human skin penetration of geraniol and citronellol. Dermatitis. 2010;21(1):41–8.

    Article  CAS  Google Scholar 

  36. White, J.M., A.C. de Groot, and I.R. White, Cosmetics and skin care products, in Contact dermatitis. 2011, Springer. p. 591–605.

  37. Li LF, Liu G, Wang J. Patch test in Chinese patients with cosmetic allergic contact dermatitis to common cosmetic allergens from a European cosmetic series. Contact Dermatitis. 2007;57(1):50–4.

    Article  CAS  Google Scholar 

  38. Krob HA, et al. Prevalence and relevance of contact dermatitis allergens: a meta-analysis of 15 years of published TRUE test data. J Am Acad Dermatol. 2004;51(3):349–53.

    Article  Google Scholar 

  39. Lim S. The associations between personal care products use and urinary concentrations of phthalates, parabens, and triclosan in various age groups: the Korean National Environmental Health Survey Cycle 3 2015–2017. Sci Total Environ. 2020;742:140640.

    Article  CAS  Google Scholar 

  40. Steinemann A. Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health. 2016;9(8):861–6.

    Article  CAS  Google Scholar 

  41. Calafat AM, McKee RH. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di (2-ethylhexyl) phthalate] as a case study. Environ Health Perspect. 2006;114(11):1783–9.

    Article  CAS  Google Scholar 

  42. Huang P-C, et al. Characterization of phthalates exposure and risk for cosmetics and perfume sales clerks. Environ Pollut. 2018;233:577–87.

    Article  CAS  Google Scholar 

  43. Gopalakrishnan K, et al. Gene expression profiles for low-dose exposure to diethyl phthalate in rodents and humans: a translational study with implications for breast carcinogenesis. Sci Rep. 2020;10(1):1–12.

    Article  CAS  Google Scholar 

  44. Caporossi L, et al. Cross sectional study on exposure to BPA and phthalates and semen parameters in men attending a fertility center. Int J Environ Res Public Health. 2020;17(2):489.

    Article  CAS  Google Scholar 

  45. Darbre, P.D. and P.W. Harvey, Regulatory considerations for dermal application of endocrine disrupters in personal care products, in Endocrine disruption and human health. 2015, Elsevier. p. 343–361.

  46. Fisher M, et al. Paraben concentrations in maternal urine and breast milk and its association with personal care product use. Environ Sci Technol. 2017;51(7):4009–17.

    Article  CAS  Google Scholar 

  47. Lincho J, Martins RC, Gomes J. Paraben compounds—part I: an overview of their characteristics, detection, and impacts. Appl Sci. 2021;11(5):2307.

    Article  CAS  Google Scholar 

  48. Karthikraj, R. and K. Kannan, Human biomonitoring of select ingredients in cosmetics, in Analysis of cosmetic products. 2018, Elsevier. p. 387–434.

  49. Gomez E, et al. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. J Toxic Environ Health A. 2005;68(4):239–51.

    Article  CAS  Google Scholar 

  50. Bilal M, Mehmood S, Iqbal H. The beast of beauty: environmental and health concerns of toxic components in cosmetics. Cosmetics. 2020;7(1):13.

    Article  CAS  Google Scholar 

  51. Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83(2):264–72.

    Article  CAS  Google Scholar 

  52. Guo Y, Kannan K. A survey of phthalates and parabens in personal care products from the United States and its implications for human exposure. Environ Sci Technol. 2013;47(24):14442–9.

    Article  CAS  Google Scholar 

  53. Leppert B, et al. Maternal paraben exposure triggers childhood overweight development. Nat Commun. 2020;11(1):1–12.

    Article  CAS  Google Scholar 

  54. Dogan S, et al. Traces of intact paraben molecules in endometrial carcinoma. Environ Sci Pollut Res. 2019;26(30):31158–65.

    Article  CAS  Google Scholar 

  55. Darbre P. Personal care products and breast cancer. Encyclop Environ Health. 2011;4:395–406.

    Article  Google Scholar 

  56. Nishihama Y, et al. Association between paraben exposure and menstrual cycle in female university students in Japan. Reprod Toxicol. 2016;63:107–13.

    Article  CAS  Google Scholar 

  57. Tokumura M, et al. Probabilistic exposure assessment of aggregate rates of dermal exposure of Japanese women and children to parabens in personal care products. Chemosphere. 2020;239:124704.

    Article  CAS  Google Scholar 

  58. Rodrigues, D.F. and E.M.A. Goulart, Patch test results in children and adolescents. Study from the Santa Casa de Belo Horizonte Dermatology Clinic, Brazil, from 2003 to 2010. Anais brasileiros de dermatologia, 2015 90(5): p. 671–683.

  59. Asimakopoulos, A.G., et al., Human exposure to chemicals in personal care products and health implications, in Personal care products in the aquatic environment. 2014, Springer. p. 165–187.

  60. Koniecki D, et al. Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res. 2011;111(3):329–36.

    Article  CAS  Google Scholar 

  61. Benohanian A. Antiperspirants and deodorants. Clin Dermatol. 2001;19(4):398–405.

    Article  CAS  Google Scholar 

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Acknowledgments

The authors gratefully acknowledge the financial support given by the Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran (Grant Number:.99-3-61-19198).

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Correspondence to Majid Kermani or Zohre Kazemi.

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Kazemi, Z., Aboutaleb, E., Shahsavani, A. et al. Evaluation of pollutants in perfumes, colognes and health effects on the consumer: a systematic review. J Environ Health Sci Engineer 20, 589–598 (2022). https://doi.org/10.1007/s40201-021-00783-x

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  • DOI: https://doi.org/10.1007/s40201-021-00783-x

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