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Effects of age on polycythemia, cardiometabolic risk and their associations in middle-aged men

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Abstract

Background

Polycythemia has been reported to be associated with cardiometabolic risk factors. However, it remains to be determined whether age affects their associations.

Methods

The subjects were 11,261 men at ages of 30 ~ 65 years who had received annual health checkup examinations. They were divided by age into four groups of 30 ~ 39, 40 ~ 49, 50 ~ 59 and 60 ~ 65 years. Variables related to polycythemia and cardiometabolic risk and their associations were compared in the different age groups.

Results

The prevalences of polycythemia and metabolic syndrome tended to be lower and higher, respectively, with an increase of age. Odds ratios (ORs) of subjects with vs. subjects without polycythemia for high LDL-C/HDL-C ratio and metabolic syndrome were significantly high in the age group of 30 ~ 39 years when compared with the reference level (OR with 95% confidence interval: 3.21 [2.35 ~ 4.37] [high LDL-C/HDL-C ratio] and 3.49 [2.38 ~ 5.12] [metabolic syndrome]) and tended to be lower with an increase of age (60 ~ 65 years, OR with 95% confidence interval: 1.36 [0.63 ~ 2.93] [high LDL-C/HDL-C ratio] and 1.88 [1.16 ~ 3.03] [metabolic syndrome]).

Conclusion

The prevalence of polycythemia was higher and its associations with cardiometabolic risk such as high LDL-C/HDL-C ratio and metabolic syndrome were stronger in the youngest group than in the older groups. The results suggest that early detection and correction of polycythemia are more effective than its later correction for prevention of cardiovascular disease in middle-aged men.

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Data Availability

The data that support the findings of this study are available from the corresponding author (IW) upon reasonable request.

Code Availability

Not applicable.

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Funding

This work was supported by the Grant-in-Aid for Scientific Research (No. 21H03386) from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Environmental and Preventive Medicine, School of Medicine, Hyogo Medical University, Mukogawa-cho 1-1, 663-8501, Nishinomiya, Hyogo, Japan

    Ichiro Wakabayashi

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  1. Ichiro Wakabayashi
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Contributions

Conceptualization, analysis, writing, and visualization, IW.

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Correspondence to Ichiro Wakabayashi.

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The author declares no conflict of interest.

Ethical approval

The database used in this study was supplied from a local health checkup system without individual identification, and no informed consent was obtained from each subject. This study was approved by the Ethics Committee of Yamagata University School of Medicine (No. 112 from April 2005 to March 2006, approved on March 13, 2006) and the Hyogo College of Medicine Ethics Committee (No. 3003 in 2020).

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Wakabayashi, I. Effects of age on polycythemia, cardiometabolic risk and their associations in middle-aged men. J Diabetes Metab Disord 22, 287–295 (2023). https://doi.org/10.1007/s40200-022-01130-z

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  • DOI: https://doi.org/10.1007/s40200-022-01130-z

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