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Diabetes affects hepatic and renal glycoproteins: effect of Boswellia ovalifoliolata on glycoproteins proportions in diabetes induced hepatic and renal injury

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Abstract

Purpose

Chronic hyperglycemia and deficiency of insulin are peculiar features of diabetes mellitus alters glycoprotein levels in various tissues leads to impaired metabolism of glycoproteins which play a major role in the pathogenesis of diabetic complications. Boswellia ovalifoliolata is a medicinal plant known for its many medicinal properties including diabetes. In this background our study was aimed to evaluate the effect of aqueous extract of stem bark of Boswellia ovalifoliolata (AESBBO) on antidiabetic and glycoprotein metabolism.

Methods

Diabetes was induced in rats by intraperitoneal administration of streptozotocin at a dose of 50 mg/kg bw. After induction of diabetes rats were treated with AESBBO at dosage of 200 mg/kg for a long term treatment of 40 days. Finally, by the end of study all the rats were dissected blood, liver, and kidney tissue samples were collected to investigate the long term effects of AESBBO on diabetes and glycoprotein metabolism.

Results

Treatment with AESBBO significantly reduced the fasting blood glucose levels whereas the levels of insulin and hemoglobin were increased with decreased levels of glycosylated hemoglobin. The long term treatment of AESBBO significantly decreased the levels of plasma, liver and kidney tissue glycoproteins such as fucose, hexose, hexosamine and sialic acid.

Conclusions

This study concludes that the aqueous extract of stem bark of Boswellia ovalifoliolata possesses a protective role on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.

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References

  1. Kar M, Chakraborti AS. Release of iron from haemoglobin-a possible source of free radicals in diabetes mellitus. Indian J Exp Biol. 1999;37:190–2.

    CAS  PubMed  Google Scholar 

  2. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782–7.

    Article  CAS  Google Scholar 

  3. Jonsson A, Wales JK. Blood glycoprotein levels in diabetes mellitus. Diabetologia. 1976;12(3):245–50.

    Article  CAS  Google Scholar 

  4. Kumar GS, Shetty AK, Salimath PV. Modulatory effect of bitter gourd (Momordica charantia LINN.) on alterations in kidney heparan sulfate in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2008;115(2):276–83.

    Article  CAS  Google Scholar 

  5. Parillo F, Arias MP, Supplizi AV. Glycoprofile of the different cell types present in the mucosa of the horse guttural pouches. Tissue Cell. 2009;41(4):257–65.

    Article  CAS  Google Scholar 

  6. Ciftci G, Yarim GF. Evaluation of IGF-I levels and serum protein profiles of diabetic cats and dogs. J Vet Sci. 2011;12(4):325–31.

    Article  Google Scholar 

  7. Neerati P, Barla R, Bedada S. Influence of diabetes mellitus on P-glycoprotein function in rat intestine. Pharmacologia. 2011;2(10):293–8.

    Article  CAS  Google Scholar 

  8. Goldenberg S, Alex M, Joshi RA, Blumenthal HT. Nonatheromatous peripheral vascular disease of the lower extremity in diabetes mellitus. Diabetes. 1959;8(4):261–73.

    Article  CAS  Google Scholar 

  9. Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 1999;48(8):1562–71.

    Article  CAS  Google Scholar 

  10. Rang HP, Dale MM, Ritter JM. The endocrine system pharmacology. Longman, Harlow. 1991:504–8.

  11. Vedavathy S, Mrudula V, Sudhakar A. Herbal medicines for birth control, ante-and post-partum treatments from Chittoor district, Andhra Pradesh. India Fitoterapia. 1995;66(6):501–6.

    Google Scholar 

  12. Sudhakar A. Pharmacognosy of some indigenous medicinal plants of Chittoor district. India: Andhra Pradesh; 2001.

    Google Scholar 

  13. Savithramma N, Venkateswarlu P, Suhrulatha D, Basha SK, Devi CV. Studies of Boswellia ovalifoliolata Bal. and Henry-an endemic and endangered medicinal plant. Bioscan. 2010;5(3):359–62.

    Google Scholar 

  14. Savithramma N, Sulochana CH. Endemic medicinal plants from Tirumala hills Andhra Pradesh. India. Fitoterapia. 1998;69(3):253–4.

    Google Scholar 

  15. Madhava Chetty K, Sivaji K, Tulasi RK. Flowering plants of Chittoor district, Andhra pradesh, India. Published by Students Offset Printers, Tirupati. 2008;61.

  16. Harbone JB. A guide to modern techniques of plant Analysis-phytochemical methods. 1998:253–62.

  17. Prince PS, Kannan NK. Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. J Pharm Pharmacol. 2006;58(10):1373–83.

    Article  Google Scholar 

  18. Sundaram R, Naresh R, Shanthi P, Sachdanandam P. Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components. Phytomedicine. 2012;19(3–4):211–6.

    Article  CAS  Google Scholar 

  19. Niebes P. Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects. Clin Chim Acta. 1972;42(2):399–408.

    Article  CAS  Google Scholar 

  20. Warren L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959;234(8):1971–5.

    CAS  PubMed  Google Scholar 

  21. Wagner WD. A more sensitive assay discriminating galactosamine and glucosamine in mixtures. Anal Biochem. 1979;94(2):394–6.

    Article  CAS  Google Scholar 

  22. Dische Z, Shettles LB. A specific color reaction of methylpentoses and a spectrophotometric micromethod for their determination. J Biol Chem. 1948;175(2):595–603.

    CAS  PubMed  Google Scholar 

  23. Kemp A, Van Heijningen AJ. A colorimetric micro-method for the determination of glycogen in tissues. Biochem J. 1954;56(4):646–8.

    Article  CAS  Google Scholar 

  24. Zachariah B, Basu D. Surface carbohydrates in cell-sociology. Indian J Biochem Biophys. 1993;30(6):422–5.

    CAS  PubMed  Google Scholar 

  25. Ganesan B, Buddhan S, Anandan R, Sivakumar R, AnbinEzhilan R. Antioxidant defense of betaine against isoprenaline-induced myocardial infarction in rats. Mol Biol Rep. 2010;37(3):1319–27.

    Article  CAS  Google Scholar 

  26. Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A. Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med. 1976;295(8):417–20.

    Article  CAS  Google Scholar 

  27. Cusi K, Consoli A, Defronzo RA. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996;81(11):4059–67.

    CAS  PubMed  Google Scholar 

  28. Veeramani C, Al-Numair KS, Alsaif MA, Chandramohan G, Al-Numair NS, Pugalendi KV. Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ–induced hyperglycemic rats. Asian Pac J Trop Med. 2012;5(12):939–44.

    Article  Google Scholar 

  29. Revathy J, Abdullah SS. Influence of hesperetin on glycoprotein components in diabetic rats. Int J Sci Eng Res. 2016;7:214–20.

    Google Scholar 

  30. Pari L, Rathinam A. Anti-diabetic effect of Myrtenal on plasma and tissue glycoproteins components in STZ induced experimental diabetic rats. J Diseases Med Plants. 2016;2(1–1):11–6.

    Article  Google Scholar 

  31. Kumar G, Murugesan AG. Influence of Helicteres isora bark extracts on plasma and tissue glycoprotein components in streptozotocin diabetic rats. J Clin Diag Res. 2007;4:330–8.

    Google Scholar 

  32. Ramkumar KM, Rajaguru P, Latha M, Ananthan R. Ethanol extract of Gymnema montanum leaves reduces glycoprotein components in experimental diabetes. Nutr Res. 2007;27(2):97–103.

    Article  CAS  Google Scholar 

  33. Guillot R, Kassab JP, Ogneva V, André J, Durussel JJ, Hadjiisky P, et al. Relation between pancreatic islet cellular infiltration and plasma fibrinogen or alpha 1-acid glycoprotein levels in spontaneously and streptozotocin-diabetic rats: an increase in these protein levels is not necessary for inducing microcirculatory erythrocyte velocity alteration. Pancreas. 1994;9(3):336–43.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Bio-Chemistry, Sri Venkateswara University, Tirupati-517 502, India

    Prabhakar Yellanur Konda, Saritha Marella, Rajesh Natava & AppaRao Chippada

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  1. Prabhakar Yellanur Konda
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  2. Saritha Marella
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  3. Rajesh Natava
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  4. AppaRao Chippada
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Correspondence to AppaRao Chippada.

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Konda, P.Y., Marella, S., Natava, R. et al. Diabetes affects hepatic and renal glycoproteins: effect of Boswellia ovalifoliolata on glycoproteins proportions in diabetes induced hepatic and renal injury. J Diabetes Metab Disord 19, 153–162 (2020). https://doi.org/10.1007/s40200-020-00487-3

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