Skip to main content
Log in

Endoscopic Skull Base Surgery in Children

  • PEDIATRIC OTOLARYNGOLOGY: Challenges in Pediatric Otolaryngology (W-C Hsu, Section Editor)
  • Published:
Current Otorhinolaryngology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Pediatric endoscopic skull base surgery (ESBS) is a field of practice that has seen significant advancement and widespread adoption from its initial description less than two decades ago. This manuscript aims to review the development of the technique with particular attention to how our knowledge of the field has increased within the past 5 years.

Recent Findings

The understanding of the anatomic nuances in the pediatric endonasal corridor has grown, especially regarding the impact of sphenoid pneumatization on outcomes and the intercarotid distance at the sella. In addition, more robust data on outcomes has shown that ESBS is safe and effective in the pediatric population. In particular, the use of the nasoseptal flap has been more successful in younger patients than previously shown. Finally, studies have shown the minimal impact of ESBS on craniofacial development.

Summary

Pediatric ESBS is minimally invasive and safe and has good patient outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: •   Of importance •• Of major importance

  1. London NR Jr, Rangel GG, Walz PC. The expanded endonasal approach in pediatric skull base surgery: a review. Laryngoscope Investig Otolaryngol. 2020;5(2):313–25.

    Article  Google Scholar 

  2. Wu T, Chandy Z, Ference E, Lee JT. Endoscopic skull base surgery in the pediatric population. Curr Treat Options Allergy. 2021;8(3):274–84.

    Article  Google Scholar 

  3. Wang EW, Zanation AM, Gardner PA, et al. ICAR: endoscopic skull‐base surgery. Paper presented at: Int Forum Allergy Rhinol. 2019.

  4. Ali ZS, Henn RE, Adappa ND, Palmer JN, Lee JY, Storm PB. Pediatric endoscopic endonasal skull base surgery: the Children's Hospital of Philadelphia experience. J Neurol Surg Part B Skull Base. 2015;76(S01):A057.

  5. Kassam A, Thomas AJ, Snyderman C, et al. Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients. J Neurosurg Pediatr. 2007;106(2):75–86.

    Article  Google Scholar 

  6. Kassam A, Snyderman CH, Mintz A, Gardner P, Carrau RL. Expanded endonasal approach: the rostrocaudal axis. Part I. Crista galli to the sella turcica. Neurosurg Focus. 2005;19(1):1–12.

  7. Kassam A, Snyderman CH, Mintz A, Gardner P, Carrau RL. Expanded endonasal approach: the rostrocaudal axis. Part II. Posterior clinoids to the foramen magnum. Neurosurg Focus. 2005;19(1):1–7.

  8. Tatreau JR, Patel MR, Shah RN, et al. Anatomical considerations for endoscopic endonasal skull base surgery in pediatric patients. Laryngoscope. 2010;120(9):1730–7.

    Article  Google Scholar 

  9. Banu MA, Rathman A, Patel KS, et al. Corridor-based endonasal endoscopic surgery for pediatric skull base pathology with detailed radioanatomic measurements. Operative Neurosurg. 2014;10(2):273–93.

    Article  Google Scholar 

  10. Banu MA, Guerrero-Maldonado A, McCrea HJ, et al. Impact of skull base development on endonasal endoscopic surgical corridors. J Neurosurg Pediatr. 2014;13(2):155–69.

    Article  Google Scholar 

  11. • Hamid O, El Fiky L, Hassan O, Kotb A, El Fiky S. Anatomic variations of the sphenoid sinus and their impact on trans-sphenoid pituitary surgery. Skull Base. 2008;18(01):009–15.

    Article  Google Scholar 

  12. Kuan EC, Kaufman AC, Lerner D, et al. Lack of sphenoid pneumatization does not affect endoscopic endonasal pediatric skull base surgery outcomes. Laryngoscope. 2019;129(4):832–6.

    Article  Google Scholar 

  13. Li L, Carrau RL, Prevedello DM, et al. Intercarotid artery distance in the pediatric population: implications for endoscopic transsphenoidal approaches to the skull base. Int J Pediatr Otorhinolaryngol. 2021;140: 110520.

    Article  Google Scholar 

  14. Shah RN, Surowitz JB, Patel MR, et al. Endoscopic pedicled nasoseptal flap reconstruction for pediatric skull base defects. Laryngoscope. 2009;119(6):1067–75.

    Article  Google Scholar 

  15. Giovannetti F, Mussa F, Priore P, et al. Endoscopic endonasal skull base surgery in pediatric patients. A single center experience. J Cranio-Maxillofacial Surg. 2018;46(12):2017–2021.

  16. Purcell PL, Shinn JR, Otto RK, Davis GE, Parikh SR. Nasoseptal flap reconstruction of pediatric sellar defects: a radiographic feasibility study and case series. Otolaryngology-Head Neck Surg. 2015;152(4):746–51.

    Article  Google Scholar 

  17. Madsen PJ, Buch VP, Douglas JE, et al. Endoscopic endonasal resection versus open surgery for pediatric craniopharyngioma: comparison of outcomes and complications. J Neurosurg Pediatr. 2019;24(3):236–45.

    Article  Google Scholar 

  18. Drapeau A, Walz PC, Eide JG, et al. Pediatric craniopharyngioma. Childs Nerv Syst. 2019;35(11):2133–45.

    Article  Google Scholar 

  19. Bogusz A, Müller HL. Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up. Expert Rev Neurother. 2018;18(10):793–806.

    Article  CAS  Google Scholar 

  20. Trifanescu R, Ansorge O, Wass JA, Grossman AB, Karavitaki N. Rathke’s cleft cysts. Clin Endocrinol. 2012;76(2):151–60.

    Article  Google Scholar 

  21. Han SJ, Rolston JD, Jahangiri A, Aghi MK. Rathke’s cleft cysts: review of natural history and surgical outcomes. J Neurooncol. 2014;117(2):197–203.

    Article  Google Scholar 

  22. Dhandapani S, Singh H, Negm HM, et al. Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas. J Neurosurg. 2017;126(2):418–30.

    Article  Google Scholar 

  23. Low CM, Vigo V, Nunez M, Fernández-Miranda JC, Patel ZM. Anatomic considerations in endoscopic pituitary surgery. Otolaryngol Clin North Am. 2022;55(2):223–32.

    Article  Google Scholar 

  24. McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP. Pediatric suprasellar tumors. J Child Neurol. 2016;31(12):1367–76.

    Article  Google Scholar 

  25. Ali ZS, Lang S-S, Kamat AR, et al. Suprasellar pediatric craniopharyngioma resection via endonasal endoscopic approach. Childs Nerv Syst. 2013;29(11):2065–70.

    Article  Google Scholar 

  26. Patel VS, Thamboo A, Quon J, et al. Outcomes after endoscopic endonasal resection of craniopharyngiomas in the pediatric population. World Neurosurg. 2017;108:6–14.

    Article  Google Scholar 

  27. Alalade AF, Ogando-Rivas E, Boatey J, et al. Suprasellar and recurrent pediatric craniopharyngiomas: expanding indications for the extended endoscopic transsphenoidal approach. J Neurosurg Pediatr. 2018;21(1):72–80.

    Article  Google Scholar 

  28. Beer-Furlan A, Todeschini AB, Carrau RL, Prevedello DM. Endoscopic endonasal approach for posterior fossa tumors. Skull Base Surg Posterior Fossa. Springer. 2018:75–86.

  29. Rajappa P, Margetis K, Sigounas D, Anand V, Schwartz TH, Greenfield JP. Endoscopic endonasal transclival approach to a ventral pontine pediatric ependymoma: case report. J Neurosurg Pediatr. 2013;12(5):465–8.

    Article  Google Scholar 

  30. Sanborn MR, Kramarz MJ, Storm PB, Adappa ND, Palmer JN, Lee JY. Endoscopic, endonasal, transclival resection of a pontine cavernoma: case report. Operative Neurosurg. 2012;71(suppl_1):onsE198-onsE203.

  31. Maggiore G, Lazio MS, Gallo O. Treatment of pediatric esthesioneuroblastoma with smell preservation. Auris Nasus Larynx. 2018;45(5):1107–12.

    Article  Google Scholar 

  32. Sigler AC, D’Anza B, Lobo BC, Woodard TD, Recinos PF, Sindwani R. Endoscopic skull base reconstruction: an evolution of materials and methods. Otolaryngol Clin North Am. 2017;50(3):643–53.

    Article  Google Scholar 

  33. Harvey RJ, Parmar P, Sacks R, Zanation AM. Endoscopic skull base reconstruction of large dural defects: a systematic review of published evidence. Laryngoscope. 2012;122(2):452–9.

    Article  Google Scholar 

  34. •• Shah N, Deopujari C, Bommakanti V. The reconstruction of skull base defects in infants using pedicled nasoseptal flap—a review of four cases. Childs Nerv Syst. 2019;35(11):2157–62. This study reports the successful use of the nasoseptal flap in four infants.

    Article  Google Scholar 

  35. Kuan EC, Carey RM, Palmer JN, Adappa ND. Special considerations for nasoseptal flap use in children. Oper Tech Otolaryngol Head Neck Surg. 2019;30(1):78–84.

    Article  Google Scholar 

  36. Stapleton AL, Tyler-Kabara EC, Gardner PA, Snyderman CH, Wang EW. Risk factors for cerebrospinal fluid leak in pediatric patients undergoing endoscopic endonasal skull base surgery. Int J Pediatr Otorhinolaryngol. 2017;93:163–6.

    Article  Google Scholar 

  37. • Ghosh A, Hatten K, Learned KO, et al. Pediatric nasoseptal flap reconstruction for suprasellar approaches. Laryngoscope. 2015;125(11):2451–6. The paper reports success in the use of the nasoseptal flap for suprasellar defects in patients < 10 years old.

    Article  Google Scholar 

  38. Lopez EM, Farzal Z, Dean KM, et al. Outcomes in pediatric endoscopic skull base surgery: a systematic review. J Neurol Surg Part B Skull Base. 2021. (AAM).

  39. Yamada S, Fukuhara N, Yamaguchi-Okada M, et al. Therapeutic outcomes of transsphenoidal surgery in pediatric patients with craniopharyngiomas: a single-center study. J Neurosurg Pediatr. 2018;21(6):549–62.

    Article  Google Scholar 

  40. Zwagerman NT, Wang EW, Shin SS, et al. Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? A prospective, randomized controlled trial. J Neurosurg. 2018;131(4):1172–8.

    Article  Google Scholar 

  41. Van Peteghem A, Clement P. Influence of extensive functional endoscopic sinus surgery (FESS) on facial growth in children with cystic fibrosis: comparison of 10 cephalometric parameters of the midface for three study groups. Int J Pediatr Otorhinolaryngol. 2006;70(8):1407–13.

    Article  Google Scholar 

  42. Bothwell MR, Piccirillo JF, Lusk RP, Ridenour BD. Long-term outcome of facial growth after functional endoscopic sinus surgery. Otolaryngology-Head Neck Surg. 2002;126(6):628–34.

    Article  Google Scholar 

  43. Senior B, Wirtschafter A, Mai C, Becker C, Belenky W. Quantitative impact of pediatric sinus surgery on facial growth. Laryngoscope. 2000;110(11):1866–70.

    Article  CAS  Google Scholar 

  44. •• Chen W, Gardner PA, Branstetter BF, et al. Long-term impact of pediatric endoscopic endonasal skull base surgery on midface growth. J Neurosurg Pediatr. 2019;23(4):523–30. This paper shows no impact on the growth of the facial skeleton if ESBS is performed prior to cranial suture fusion.

    Article  Google Scholar 

  45. •• Parasher AK, Lerner DK, Glicksman JT, et al. The impact of expanded endonasal skull base surgery on midfacial growth in pediatric patients. Laryngoscope. 2020;130(2):338–42. This paper showed no difference in craniofacial measurements between children who had undergone ESBS versus open surgery.

    Article  Google Scholar 

  46. Ben-Ari O, Wengier A, Ringel B, et al. Nasoseptal flap for skull base reconstruction in children. J Neurol Surg Part B: Skull Base. 2018;79(01):037–41.

    Article  Google Scholar 

Download references

Funding

Internal departmental funding was utilized without commercial sponsorship or support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter H. Hwang.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Pediatric Otolaryngology: Challenges in Pediatric Otolaryngology

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Low, C.M., Hwang, P.H. Endoscopic Skull Base Surgery in Children. Curr Otorhinolaryngol Rep 10, 440–446 (2022). https://doi.org/10.1007/s40136-022-00432-3

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40136-022-00432-3

Keywords

Navigation