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Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study

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Abstract

Background

The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients.

Methods

Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals.

Results

We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients.

Discussion

Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.

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Abbreviations

BMI:

Body mass index

SSI:

Surgical site infection

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Author information

Authors and Affiliations

  1. Neurochirurgie, CHU de Limoges, Limoges, France

    Henri Salle, Anne-Claire Beaujeux, Leslie Lemnos & François Caire

  2. CAPTuR, EA 3842, Université de Limoges, Limoges, France

    Henri Salle

  3. Oncologie médicale, CHU de Limoges, Limoges, France

    Elise Deluche

  4. Hygiène, CHU de Limoges, Limoges, France

    Elodie Couvé-Deacon

  5. Neurochirurgie, GHU Paris – Hôpital Sainte-Anne, Paris, France

    Johan Pallud & Alexandre Roux

  6. IMA-BRAIN, UMR1266, Inserm, Paris, France

    Johan Pallud & Alexandre Roux

  7. Neurochirurgie, BCRM Toulon, HIA Sainte-Anne, Toulon, France

    Arnaud Dagain

  8. Neurochirurgie, CHU de Toulouse, Hopital Pierre-Paul Riquet, Toulouse, France

    Amaury de Barros

  9. Neurochirurgie, Hôpitaux Civils de Colmar, Colmar, France

    Jimmy Voirin

  10. Neurochirurgie, CHU de Strasbourg, Strasbourg, France

    Jimmy Voirin & Hélène Cebula

  11. Neurochirurgie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France

    Romuald Seizeur & Houda Belmabrouk

  12. Université de BREST, LaTIM INSERM UMR 1101, Brest, France

    Romuald Seizeur

  13. Neurochirurgie, CHU Caen Normandie, Caen, France

    Evelyne Emery

  14. Université CAEN Normandie, Inserm U 12 37, Cycéron, Caen, France

    Evelyne Emery

  15. Neurochirurgie, CHU de Saint-Etienne, Saint-Etienne, France

    Marie-Jeanne Fotso

  16. Neurochirurgie, CHU de Bordeaux, Bordeaux, France

    Julien Engelhardt & Vincent Jecko

  17. INCIA, UMR 5287, Université de Bordeaux, CNRS, Bordeaux, France

    Vincent Jecko

  18. Neurochirurgie, CHU de Tours, Tours, France

    Ilyess Zemmoura

  19. iBrain, UMR 1253, Université de Tours, Inserm, Tours, France

    Ilyess Zemmoura

  20. Neurochirurgie, CHU de Dijon, Dijon, France

    Tuan Le Van

  21. Neurochirurgie, CHU de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France

    Moncef Berhouma

  22. Creatis Laboratory, , CNRS UMR 5220, INSERM U1206, Université Lyon 1/INSA, Lyon, France

    Moncef Berhouma

  23. Neurochirurgie, APHP, Groupe Hospitalier Pitié Salpêtrière, Paris, France

    Matthieu Peyre

  24. Genetics and Development of Brain Tumors - CRICM INSERM U1127 CNRS UMR 7225, Paris, France

    Matthieu Peyre

  25. Centre d’Epidémiologie, CHU de Limoges, de Biostatistiques Et de Méthodologie de La Recherche CEBIMER, Limoges, France

    Pierre-Marie Preux

  26. XLIM, UMR 7252, Université de Limoges, CNRS, Limoges, France

    François Caire

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  1. Henri Salle
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  2. Elise Deluche
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Correspondence to Henri Salle.

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Salle, H., Deluche, E., Couvé-Deacon, E. et al. Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study. Infection 49, 267–275 (2021). https://doi.org/10.1007/s15010-020-01534-0

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