Skip to main content

Advertisement

SpringerLink
Log in

Fulminant acute hemorrhagic leukoencephalopathy: ineffective treatment with immunotherapy

  • Neuro-Images
  • Published:
Acta Neurologica Belgica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Tenembaum S, Chitnis T, Ness J, Hahn JS, International Pediatric MS Study Group (2007) Acute disseminated encephalomyelitis. Neurology 68:23–36

    Article  Google Scholar 

  2. Ichikawa K, Motoi H, Oyama Y, Watanabe Y, Takeshita S (2013) Fulminant form of acute disseminated encephalomyelitis in a child treated with mild hypothermia. Pediatr Int 55:149–151

    Article  Google Scholar 

  3. Panchal A, Perez-Marques F (2018) Intravenous immunoglobulin for acute hemorrhagic leukoencephalitis refractory to plasmapheresis. Clin Case Rep 7:160–163

    Article  Google Scholar 

  4. Payne ET, Rutka JT, Ho TK, Halliday WC, Banwell BL (2007) Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis. J Child Neurol 22:109–113

    Article  Google Scholar 

  5. Kuperan S, Ostrow P, Landi MK, Bakshi R (2003) Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings. Neurology 60:721–722

    Article  Google Scholar 

  6. Mader I, Wolff M, Niemann G, Küker W (2004) Acute haemorrhagic encephalomyelitis (AHEM): MRI findings. Neuropediatrics 35:143–146

    Article  CAS  Google Scholar 

  7. Rosman NP, Gottlieb SM, Bernstein CA (1997) Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child. J Child Neurol 12:448–454

    Article  CAS  Google Scholar 

  8. Lann MA, Lovell MA, Kleinschmidt-DeMasters BK (2010) Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. Am J Forensic Med Pathol 31:7–11

    Article  Google Scholar 

  9. Yae Y, Kawano G, Yokochi T et al (2019) Fulminant acute disseminated encephalomyelitis in children. Brain Dev 41:373–377

    Article  Google Scholar 

  10. Konuskan B, Yildirim M, Gocmen R et al (2018) Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. Mult Scler Relat Disord 26:1–7

    Article  Google Scholar 

  11. Michinaga S, Koyama Y (2015) Pathogenesis of brain edema and investigation into anti-edema drugs. Int J Mol Sci 16:9949–9975

    Article  CAS  Google Scholar 

  12. Kaufmann AM, Cardoso ER (1992) Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg 77:584–589

    Article  CAS  Google Scholar 

Download references

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

Author information

Authors and Affiliations

  1. Department of Pediatric Neurology, Faculty of Medicine, Ankara University, Ankara, 06590, Turkey

    Mirac Yildirim

  2. Department of Pediatric Radiology, Konya Research and Training Hospital, Konya, Turkey

    Avni Merter Keceli

  3. Department of Pediatrics, Konya Research and Training Hospital, Konya, Turkey

    Nazmi Simsek & Celebi Kocaoglu

Authors
  1. Mirac Yildirim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Avni Merter Keceli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nazmi Simsek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Celebi Kocaoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mirac Yildirim.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

This article does not contain any studies with human participants besides routine clinical diagnostics by any of the authors.

Informed consent

No personally identifiable information is available in this study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Appendix

Appendix

Microbiological tests were as follows; blood, urine, and CSF culture; serum serological examinations including herpes simplex virüs (HSV) type 1 and 2, parvovirus B19, Ebstein-Barr virüs (EBV), Chlamydia pneumoniae, and Mycoplasma pneumonia serology; CSF viral PCR tests including HSV type 1 and 2, varicella zoster virus (VZV), cytomegalovirus (CMV), EBV, adenovirus, enterovirus, parechovirus, parvovirus B19, and human herpes virus type 6 and 7; nasopharyngeal swab test including adenovirus, metapneumovirus A and B, parainfluenza viruses 1, 2, 3 and 4, rhinovirus, respiratory syncytial virüs A and B, enterovirus, influenza viruses A, B and C.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yildirim, M., Keceli, A.M., Simsek, N. et al. Fulminant acute hemorrhagic leukoencephalopathy: ineffective treatment with immunotherapy. Acta Neurol Belg 122, 529–533 (2022). https://doi.org/10.1007/s13760-020-01568-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13760-020-01568-z

Keywords

Search

Navigation