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Ommaya reservoir in the treatment of cryptococcal meningitis

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Abstract

The objective is to study the role of Ommaya reservoir in the treatment of cryptococcal meningitis. The clinical data of 42 patients with cryptococcal meningitis were retrospectively studied. The Ommaya group included 20 patients, who were treated with Amphotericin B (Am B) and Ommaya reservoir implantation. The non-Ommaya group contained 22 patients, who were just treated with Amphotericin B (Am B). In the Ommaya group (surgical group), all 20 patients with Ommaya reservoir were fully recovered, and their average hospital stay period and average treatment period with Amphotericin B were 105.3 ± 18.3 and 75.0 ± 18.1 days, respectively. In the non-Ommaya group (control group), 16 patients were fully recovered and the average hospital stay period and average treatment period with Amphotericin B of these 22 patients were 139.6 ± 29.5 and 150.0 ± 32.2 days, respectively. In the surgical group, average period of cryptococcus disappearance was 20 ± 8 days, while in the control group, that was 35 ± 10 days. The clinical efficacy was better in surgical group than control group (P < 0.05). Ommaya reservoir implantation is a valuable approach in the treatment of cryptococcal meningitis and can improve the cure rate, decrease mortality, and shorten the period of treatment.

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    Authors and Affiliations

    1. Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China

      Baozhu Wei, Cheng Qian, Jing Wan & Yanggan Wang

    2. Department of Endocrinology, China Resource and WISCO General Hospital, Wuhan, China

      Yang Liu & Xuan Lin

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    1. Baozhu Wei
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    2. Cheng Qian
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    3. Yang Liu
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    4. Xuan Lin
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    5. Jing Wan
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    6. Yanggan Wang
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    Corresponding authors

    Correspondence to Jing Wan or Yanggan Wang.

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    The authors declare no conflict of interest.

    Ethical approval

    The study protocol was approved by Zhongnan Hospital Bioethics Committee of Wuhan University.

    Informed consent

    Written informed consent was obtained from the patient.

    Additional information

    Baozhu Wei and Cheng Qian are contributed equally and should be treated as co-first authors.

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    Wei, B., Qian, C., Liu, Y. et al. Ommaya reservoir in the treatment of cryptococcal meningitis. Acta Neurol Belg 117, 283–287 (2017). https://doi.org/10.1007/s13760-016-0682-6

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    • DOI: https://doi.org/10.1007/s13760-016-0682-6

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