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Predictive value of health-related quality of life in progression of disability and depression in persons with multiple sclerosis: a 3-year study

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A Commentary to this article was published on 11 June 2013

Abstract

In our study, we examined whether health-related quality of life (HRQoL) could predict changes in disability, depression, and fatigue in patients with multiple sclerosis (MS) over a 3-year follow-up period. A group of 109 consecutive MS patients (McDonald’s criteria) referring to the Institute of Neurology, Belgrade were enrolled in the study. At two time points during the study (baseline, and after a 3-year period) an HRQoL (measured by MSQoL-54), EDSS, Hamilton Rating Scale for Depression (HDRS) and Fatigue Severity Scale (FSS) were assessed. At the end of a 3-year follow-up, 12 out of 109 patients (11 %) had dropped out. Multiple linear regression analysis showed that Physical Health scale of MSQoL-54 is significant independent predictor of change in EDSS after 3 years (p = 0.035). Mental health composite score of MSQoL-54 was predictor of change in HDRS score (p = 0.049). In separate regression analysis, only social function was independent predictor of the development of depression (p = 0.041). None of the HRQoL domains had predictive effect on the change of FSS. Our study suggests that baseline HRQoL scores, measured by MSQoL-54, could be applied as a prognostic marker for progression of both, disability, and severity of depressive symptoms in MS.

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Acknowledgments

This work was supported by the Ministry of Education and Science of the Republic of Serbia (Grants No. 175087 and 175031).

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Authors and Affiliations

  1. Faculty of Medicine, Institute of Epidemiology, University of Belgrade, Visegradska 26, 11000, Belgrade, Serbia

    Darija Kisic Tepavcevic & Tatjana Pekmezovic

  2. Faculty of Medicine, Clinic of Neurology, Clinical Center of Serbia, University of Belgrade, Dr Subotica 6, 11000, Belgrade, Serbia

    Nebojsa Stojsavljevic, Jelena Kostic, Irena Dujmovic Basuroski, Sarlota Mesaros & Jelena Drulovic

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  1. Darija Kisic Tepavcevic
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  2. Tatjana Pekmezovic
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  3. Nebojsa Stojsavljevic
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  4. Jelena Kostic
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  6. Sarlota Mesaros
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  7. Jelena Drulovic
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Correspondence to Jelena Drulovic.

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Tepavcevic, D.K., Pekmezovic, T., Stojsavljevic, N. et al. Predictive value of health-related quality of life in progression of disability and depression in persons with multiple sclerosis: a 3-year study. Acta Neurol Belg 113, 403–409 (2013). https://doi.org/10.1007/s13760-013-0191-9

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  • DOI: https://doi.org/10.1007/s13760-013-0191-9

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