Abstract
Dedifferentiated liposarcoma is a rare cancer with a poor prognosis. A 52-year-old man presented with a chief complaint of a mass in his left scrotum. He came with suspected testicular tumor, but all the measured tumor markers were negative. Imaging test showed approximately 2 cm diameter mass accompanied by calcification with some substantial components between the testis and epididymis. Left high testicular resection was performed. The tumor had no continuity between the testis and epididymis, and the spermatic cord transection was negative. Pathological findings showed well differentiated fatty component and a dedifferentiated component around the trabecular bone-like tissue. We observed dedifferentiated dysmorphic cells mixed with fatty droplets of unequal size. Immunostaining led to the diagnosis of dedifferentiated liposarcoma. No additional postoperative therapy was performed. The possibility of dedifferentiated liposarcoma should be kept in mind even if mass is confined to the scrotum and consisted of calcification. In the case of an intrascrotal calcified mass with malignant perspective, radical surgery is highly recommended.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
The data in this report are available on request from the corresponding author.
References
Nishio J et al (2011) Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. J Biomed Biotechnol 2011:524067
Waters R, Horvai A, Greipp P et al (2019) Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged ≤40 years: a study of 116 patients. Histopathology 75:833–842
Ishibashi Y et al (2022) A case of dedifferentiated liposarcoma of the spermatic cord. Acta Urol 68:17–21
Kumada N et al (2020) A case of liposarcoma of the spermatic cord. Toyota J Med 29:62–66
Takaoka N et al (2019) A case of dedifferentiated liposarcoma of the spermatic cord. Acta Urol 65:529–532
Tobiume M et al (2019) A case of dedifferentiated liposarcoma of the spermatic cord. Acta Urol 65:429–434
Shinohara M et al (2019) A case of dedifferentiated liposarcoma in the scrotum. J Urol Surg 32:307
Ando T et al (2018) Dedifferentiated spermatic cord liposarcoma with macroscopic ossification. IJU 1:5–8
Oshikawa Y et al (2018) A case of liposarcoma in the scrotum in the very elderly. Nishi Nihon Hinyokika 80:305
Tanaka S et al (2013) A case of dedifferentiated liposarcoma of the spermatic cord. J Urol Surg 26:754
Akaihata H et al (2009) A case of liposarcoma occurring in the scrotum. Jpn J Urol 63:811–815
Evans HL et al (1979) Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 3:507–523
Gondo T et al (2007) Retroperitoneal dedifferentiated liposarcoma: case report. Jpn J Urol 98:795–799
Nishio J et al (2021) Biology and management of dedifferentiated liposarcoma: state of the art and perspectives. J Clin Med 10(15):3230
Livingston JA, Bugano D, Barbo A et al (2017) Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard. Sci Rep 19:11836
Schöffski P, Chawla S, Maki RG et al (2016) Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet 387:1629–1637
Demetri GD, Von Mehren M, Jones RL et al (2016) Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a phase III randomized multicenter clinical trial. J Clin Oncol 34:786–793
Bauer TM, Gounder MM, Weise AM et al (2018) A phase 1 study of MDM2 inhibitor DS-3032b in patients with well/de-differentiated liposarcoma (WD/DD LPS), solid tumors (ST) and lymphomas (L). J Clin Oncol 36:11514
Nagae I et al (2007) A case of differentiated liposarcoma of the spermatic cord with widely infiltrative local recurrence. Jpn J Gastroenterol Surg 40:349–354
Acknowledgements
We express our sincere thanks to Ehime Urological Association for the cost of publication.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that have no conflict of interest.
Approval of the research protocol by an Institutional Reviewer Board
Not applicable.
Informed consent
Informed consent was obtained.
Registry and the Registration No. of the study/trial
Not applicable.
List of supporting information
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Arai, H., Sogabe, H., Morikawa, S. et al. A case of dedifferentiated liposarcoma discovered due to an intrascrotal calcified ossification. Int Canc Conf J (2024). https://doi.org/10.1007/s13691-024-00682-6
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s13691-024-00682-6