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A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases

  • Case Report - Radiotherapy
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Abstract

Brain metastases from bladder cancer are rare, with a poor prognosis. There is no standard treatment for bladder cancer with brain metastases; thus, palliative therapy is generally provided. We report a case of abscopal effect in a single brain metastasis from bladder cancer in a patient treated with focal stereotactic radiotherapy (total dose = 52 Gy, administered in eight fractions) with immune checkpoint blockade therapy for lung metastases, who achieved long-term disease-free survival (> 4 years). To our knowledge, although there have been some reports on abscopal effects in bladder cancer, there are no previous reports on patients with brain metastases. To date, the brain metastasis, which showed an “abscopal effect,” continues to maintain complete regression.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

The authors declare that they have received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Radiation Oncology, Tokyo Women’s Medical University School of Medicine, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan

    Sawa Kono, Yaichiro Hashimoto, Kenta Ohmatsu, Miki Kawanishi, Shigehiko Kuribayashi & Kumiko Karasawa

  2. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University School of Medicine, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan

    Yurie Shirai & Yasuhiro Kunihiro

Authors
  1. Sawa Kono
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  2. Yaichiro Hashimoto
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  3. Yurie Shirai
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  4. Yasuhiro Kunihiro
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  5. Kenta Ohmatsu
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  6. Miki Kawanishi
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  7. Shigehiko Kuribayashi
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  8. Kumiko Karasawa
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Yasuhiro Kunihiro, Kenta Ohmatsu and Miki Kawanishi, Shigehiko Kuribayashi and Kumiko Karasawa. The first draft of the manuscript was written by Sawa Kono and Yaichiro Hashimoto. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yaichiro Hashimoto.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from the individual participant included in the study.

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Kono, S., Hashimoto, Y., Shirai, Y. et al. A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases. Int Canc Conf J 12, 205–209 (2023). https://doi.org/10.1007/s13691-023-00606-w

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  • DOI: https://doi.org/10.1007/s13691-023-00606-w

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