Skip to main content
SpringerLink
Log in

6p.21 translocation renal cell carcinoma in the elderly: radiological findings mimicking fat poor angiomyolipoma or papillary renal cell carcinoma

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

6p21 translocation renal cell carcinoma (RCC) harboring TFEB gene fusion is a newly classified microphthalmia-associated transcription (MiT) factor-family translocation RCC with early onset. We present a case of 78-year-old man with a 6p21 translocation RCC that was diagnosed after partial nephrectomy for an incidental renal tumor on computed tomography (CT). Unenhanced CT showed a 20 mm, mildly low-density mass in the right kidney. Contrast-enhanced CT showed a heterogeneous and prolonged, mild enhancement in the tumor. On magnetic resonance imaging, the tumor showed iso-intensity within the renal parenchyma on T1-weighted-imaging (WI), low intensity on T2WI, and no restricted diffusion with low signal on diffusion-weighted imaging, with no clear tumor pseudocapsule. Fat poor angiomyolipoma and non-clear cell RCC were listed as differential diagnoses. Robot-assisted partial nephrectomy was successfully performed. Fluorescence in situ hybridization study of the resected tumor confirmed TFEB gene break, and the patient was diagnosed with a 6p21 translocation RCC. The patient is doing well without recurrence after 2.5 years of follow-up. Our patient is the oldest patient reported in previous literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Kuroda N, Tanaka A, Sasaki N et al (2013) Review of renal carcinoma with t (6;11) (p21;q12) with focus on clinical and pathobiological aspects. Histol Histopathol 28:685–690

    PubMed  Google Scholar 

  2. Moch H, Humphrey PA, Ulbright TM (2016) WHO classification oftumours of the urinary system and male genital organs, 4th edn. IARC Press, Lyon

    Google Scholar 

  3. Kuroda N, Yorita K, Sasaki N et al (2017) Clinicopathological study of 5 cases of renal cell carcinoma with t(6;11)(p21;q12). Pol J Pathol 68:66–72

    Article  Google Scholar 

  4. Ishihara A, Yamashita Y, Takamori H et al (2011) Renal carcinoma with (6;11)(p21;q12) translocation: report of an adult case. Pathol Int 61:539–545

    Article  CAS  Google Scholar 

  5. Hora M, Urge T, Trávníček I et al (2014) MiT translocation renal cell carcinomas: two subgroups of tumours with translocations involving 6p21 [t (6; 11)] and Xp11.2 [t (X;1 or X or 17)]. J Springerplus 3:245

    Article  Google Scholar 

  6. Smith NE, Illei PB, Allaf M et al (2014) t(6;11) renal cell carcinoma (RCC): expanded immunohistochemical profile emphasizing novel RCC markers and report of 10 new genetically confirmed cases. Am J Surg Pathol 38:604–614

    Article  Google Scholar 

  7. Macher-Goeppinger S, Roth W, Wagener N et al (2012) Molecular heterogeneity of TFE3 activation in renal cell carcinomas. Mod Pathol 25:308–315

    Article  CAS  Google Scholar 

  8. Inamura K (2017) Translocation renal cell carcinoma: an update on clinicopathological and molecular features. Cancers (Basel) 9:111

    Article  Google Scholar 

  9. Argani P, Laé M, Hutchinson B et al (2005) Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol 29:230–240

    Article  Google Scholar 

  10. Kato H, Kanematsu M, Yokoi S et al (2011) Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: radiological findings mimicking papillary subtype. J Magn Reson Imaging 33:217–220

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan

    Yoichiro Tohi, Satoshi Harada, Nobufumi Ueda & Mikio Sugimoto

  2. Department of Diagnostic Pathology, Kobe Kyodo Hospital, Kobe, Hyogo, Japan

    Naoto Kuroda

  3. Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Kenichi Tanaka & Yoshihiro Nishiyama

  4. Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Kosuke Inoue, Kyuichi Kadota & Reiji Haba

Authors
  1. Yoichiro Tohi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Satoshi Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Naoto Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenichi Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kosuke Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kyuichi Kadota
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Reiji Haba
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yoshihiro Nishiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Nobufumi Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Mikio Sugimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoichiro Tohi.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

For this type of study, formal consent is not required. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from the patient included in this study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tohi, Y., Harada, S., Kuroda, N. et al. 6p.21 translocation renal cell carcinoma in the elderly: radiological findings mimicking fat poor angiomyolipoma or papillary renal cell carcinoma. Int Canc Conf J 10, 233–238 (2021). https://doi.org/10.1007/s13691-021-00486-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-021-00486-y

Keywords

Search

Navigation