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Concurrent high-grade serous carcinoma and borderline tumor demonstrating different chemo-sensitivity

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Abstract

Ovarian high-grade serous adenocarcinoma responds well to regular platinum/taxane chemotherapy, while borderline tumor survives and demonstrates persistent disease. A 69-year-old Japanese woman was suspected for having advanced ovarian carcinoma. MRI showed cystic tumor containing solid component of the right adnexal region with massive ascites and peritoneal dissemination. Serum CA125 was elevated to 203 µ/ml; however, no remote metastases were detected. Laparotomy revealed that peritoneal carcinomatosis spreads out to omentum and subphrenic area. Omentum was partially removed with big tumor nodules that histologically demonstrated the high-grade serous adenocarcinoma with positive ascites cytology. After 6 cycles of postoperative chemotherapy with docetaxel and carboplatin, she received second surgery where the known residual bilateral adnexa and all of the persistent tumors were perfectly resected. Pathological examination of the tumor revealed serous borderline tumor with microinvasion and no evidence of residual high-grade serous carcinoma with negative ascites cytology. This is the extremely rare case of concurrent high-grade serous carcinoma and borderline tumor demonstrating differential chemo-sensitivity.

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Acknowledgements

Authors would like to thank English Lectures Paul Raine, Jikei University School of Medicine for their comments in English.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Jikei Daisan Hospital, 4-11-1 Izumi-Honchou, Komae-shi, Tokyo, 201-8601, Japan

    Momoko Inoue, Masataka Takenaka & Seiji Isonishi

  2. Department of Pathology, Jikei Daisan Hospital, 4-11-1 Izumi-Honchou, Komae-shi, Tokyo, 201-8601, Japan

    Masaharu Fukunaga

Authors
  1. Momoko Inoue
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  2. Masataka Takenaka
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  3. Masaharu Fukunaga
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  4. Seiji Isonishi
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Correspondence to Seiji Isonishi.

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The authors report no conflicts of interest.

Informed consent

This patient has already died of disease more than a year ago. At this moment, we could not keep track of the patient’s guardian or next of kin and the written consent could not be available. In the report described here, all personal details of the patient were removed from the case report to ensure that the patient cannot be identified.

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Inoue, M., Takenaka, M., Fukunaga, M. et al. Concurrent high-grade serous carcinoma and borderline tumor demonstrating different chemo-sensitivity. Int Canc Conf J 6, 65–69 (2017). https://doi.org/10.1007/s13691-016-0275-5

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  • DOI: https://doi.org/10.1007/s13691-016-0275-5

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